Patents by Inventor Ikuko KOZONE

Ikuko KOZONE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compound having therapeutic activity against mycobacterium avium complex infection, and method for producing same
    Patent number: 11407742
    Abstract: The purpose of the present invention is to provide a novel compound which has antibacterial activity against Mycobacterium avium and Mycobacterium intracellulare that are causative bacteria of MAC infection and which is different in backbone structure from known drugs for treatment of MAC infection. One aspect of the present invention relates to a compound of Formula (I) [where R1 has the same meaning as described in the specification and claims] or a salt thereof, or a solvate thereof. Another aspect of the present invention relates to a method for producing the compound of Formula (I) or a salt thereof, or a solvate thereof, and a therapeutic agent for Mycobacterium avium complex infection (MAC infection), which comprises the compound or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof as an active ingredient.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: August 9, 2022
    Assignees: THE KITASATO INSTITUTE, OP BIO FACTORY CO., LTD.
    Inventors: Hiroshi Tomoda, Nobuhiro Koyama, Akihiko Kanamoto, Junko Hashimoto, Ikuko Kozone
  • METHOD FOR PRODUCING COMPOUND WITH MODIFIED MOTHER NUCLEUS
    Publication number: 20220090100
    Abstract: The present invention provides a method for producing a modified compound, including the following steps: (1) a step of cleaving in vitro using a CRISPR/Cas9 system, a target site in a gene cluster involved in the biosynthesis of a compound, (2) a step of connecting using Gibson assembly in vitro the gene cluster cleaved in step (1) and a polynucleotide for modification, and (3) a step of expressing the modified gene cluster obtained in step (2) in a microorganism expression system.
    Type: Application
    Filed: January 30, 2020
    Publication date: March 24, 2022
    Applicant: JAPAN BIOLOGICAL INFORMATICS CONSORTIUM
    Inventors: Kazuo SHINYA, Haruo IKEDA, Mamoru KOMATSU, Junko HASHIMOTO, Ikuko KOZONE, Takuya HASHIMOTO, Kei KUDO
  • NOVEL COMPOUND HAVING THERAPEUTIC ACTIVITY AGAINST MYCOBACTERIUM AVIUM COMPLEX INFECTION, AND METHOD FOR PRODUCING SAME
    Publication number: 20200407346
    Abstract: The purpose of the present invention is to provide a novel compound which has antibacterial activity against Mycobacterium avium and Mycobacterium intracellulare that are causative bacteria of MAC infection and which is different in backbone structure from known drugs for treatment of MAC infection. One aspect of the present invention relates to a compound of Formula (I) [where R1 has the same meaning as described in the specification and claims] or a salt thereof, or a solvate thereof. Another aspect of the present invention relates to a method for producing the compound of Formula (I) or a salt thereof, or a solvate thereof, and a therapeutic agent for Mycobacterium avium complex infection (MAC infection), which comprises the compound or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof as an active ingredient.
    Type: Application
    Filed: August 30, 2018
    Publication date: December 31, 2020
    Applicants: THE KITASATO INSTITUTE, OP BIO FACTORY CO., LTD.
    Inventors: Hiroshi TOMODA, Nobuhiro KOYAMA, Akihiko KANAMOTO, Junko HASHIMOTO, Ikuko KOZONE