Abstract: A deinking agent comprises a compound of the following formula (I);N(R.sup.1)(R.sup.1) R.sup.2 (I)wherein R.sup.1 is --C(O)R.sup.4 or --(C.sub.2 H.sub.4 O)C(O)R.sup.4 ; R.sup.2 is --(C.sub.2 H.sub.4 O)--(AO).sub.m or --(AO).sub.m ; R.sup.3 is --C(O)R.sup.4 or --(C.sub.2 H.sub.4 O)C(O)R.sup.4 ; R.sup.4 is C.sub.9-23 alkyl or C.sub.9-23 alkenyl; m is a integer from 40 to 100 and A is C.sub.2-4 alkylene, and a quaternary ammonium compound thereof in a molar ratio of 9/1 to 1/9. The deinking agent for reclaiming printed waste paper has abilities to efficiently release the ink from the waste paper in the disintegration process and to collect the ink and produce suitable foam in the flotation process, which provides high quality reclaimed pulp having high whiteness and a low content of remaining ink.

Abstract: A method useful for the treatment or prevention of diseases caused by a massive release of cerebral glutamate, in particular epilepsy and dementia, and pharmaceutical formulations therefor, which comprise, as an active ingredient, a therapeutically effective amount of methyl (+)-(4S)-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2,3-b]pyr idine-5-carboxylate (S-312-d).

Abstract: Novel Ca-blockers, 4,7-dihydropyrazolo[3,4-b]pyridine derivatives having potent antihypertensive and coronary vasodilating actions and useful in treatment for diseases in circulatory system, but without systole inhibitory action.

Abstract: Highly effective calcium channel blockers having potent antihypertensive and coronary vasodilating actions, i.e. 4,7-dihydrothieno[2,3-b]pyridine derivatives of the formula: ##STR1## wherein R.sup.1 is straight or branched chain C.sub.1 -C.sub.4 alkyl, alkoxyalkyl, or arylalkyl; R.sup.2 is hydrogen, straight or branched chain C.sub.1 -C.sub.4 alkyl, or alkoxycarbonyl; R.sup.3 is hydrogen, straight or branched chain C.sub.1 -C.sub.4 alkyl, phenyl which may be substituted by one or more halogens or alkoxy groups, optionally substituted cycloalkyl, or optionally substituted cycloalkylalkyl; or R.sub.2 and R.sup.3 taken together may form an alkylene.

Abstract: 1,6-Dialkyl-3-substituted-4-nitrophenyl-4,7-dihydropyrazolo[3,4-b]pyridine- 5-carboxylic acid esters as Ca blocker having potent antihypertensive and coronary vasodilating actions and useful in treatment of diseases in circulatory system such as angina pectoris, hypertension, cerebrovascular dysfunction, arrhythmia, etc. with no systole inhibitory action, prepared from nitrobenzylideneacetoacetic acid esters on reaction with 3-substituted-5-amino-1-alkylpyrazoles.

Abstract: Lower alkyl 2-chloro-2-hydroxyiminoacetates are produced by (A) reacting chloral with a lower alkanol and a hydroxylamine salt in the presence of a Lewis acid or a metal oxide which is convertible into said Lewis acid during the course of the reaction to give a lower alkyl 2-hydroxyiminoacetate and then chlorinating the resulting product or (B) reacting chloral oxime with a lower alkanol in the presence of a base to give a lower alkyl 2-hydroxyiminoacetate and finally chlorinating the thus formed product.

Abstract: 3-Substituted-4-(5, 6, or 7)-(2-hydroxy-3-substituted aminopropoxy)-1,2-benzisoxazoles synthesized from 3-substituted-4 (5, 6, or 7)-(2,3-epoxypropoxy)-1,2-benzisoxazoles with a primary amine showing .beta.-blocking activity with low toxicity.

Abstract: A method of manufacturing methallyl sulfonate, which comprises: forming a sulfur trioxide-dialkyl sulfoxide complex by effecting reaction between sulfur trioxide and dialkyl sulfoxide as mixed at the ratio of more than 0.8 mol of the latter to 1 mol of the former in the presence of an inert solvent; effecting reaction between said complex and isobutylene, in an amount of 0.9-1.2 mols of isobutylene per 1 mol of sulfur trioxide, by applying a temperature in the range of 10.degree.-80.degree.C; and neutralizing the reaction product with a base.