Abstract: The present invention chiefly aims to provide a new differentiation inducing agent (peptide) that can solve the previous problems in inducing differentiation of pluripotent stem cells such as ES/iPS cells into somatic cells (e.g., cardiomyocytes). The present invention can include, for example, a synthetic peptide having, in the molecular structure thereof, an amino acid sequence represented by the following (SEQ ID NO: 1), or an amino acid sequence formed by substitution, deletion and/or addition of one or several amino acid residues in the amino acid sequence. It can also include, for example, a composition for inducing differentiation of pluripotent stem cells into somatic cells, comprising said synthetic peptide. (SEQ?ID?No.

Abstract: A sheet feeding device, which is included in an image forming apparatus and includes a device attachment body, includes a sheet container configured to accommodate a sheet, a support configured to support a lower face of the sheet in the sheet container, a sheet width regulator configured to regulate a position of the sheet in a sheet width direction, a conveying force applier configured to apply a sheet conveying force in a sheet conveying direction to the sheet in the sheet container, and a sheet guide disposed above the sheet in the sheet container and configured to regulate movement of the sheet in an upper direction.

Abstract: A sheet feeding device, which is included in an image forming apparatus and includes a device attachment body, includes a sheet container configured to accommodate a sheet, a support configured to support a lower face of the sheet in the sheet container, a sheet width regulator configured to regulate a position of the sheet in a sheet width direction, a conveying force applier configured to apply a sheet conveying force in a sheet conveying direction to the sheet in the sheet container, and a sheet guide disposed above the sheet in the sheet container and configured to regulate movement of the sheet in an upper direction.

Abstract: A sheet feeder, which is included in an image forming apparatus, includes a sheet loader on which a sheet is loaded, a sheet feeding body to feed the sheet from the sheet loader, and a sheet separator disposed to contact the sheet feeding body. The sheet is fed at a first average sheet feeding speed at which the sheet feeding body is in contact with the sheet separator without holding the sheet with the sheet separator. The sheet is fed at a second average sheet feeding speed at which the sheet feeding body is holding the sheet with the sheet separator. The first average sheet feeding speed is set smaller than the second average sheet feeding speed.

Abstract: [Problem to be solved] To provide a drug delivery system capable of delivering a drug into a cell expressing a VEGF receptor. [Solution] Provided is a VEGF-binding peptide-drug complex in which a drug is bound to a C-terminal amino acid and/or an N-terminal amino acid of a VEGF-binding peptide and is incorporated into a VEGF receptor-expressing cell by endocytosis of a VEGF receptor, the VEGF-binding peptide having a helix-loop-helix structure including an A block that includes a peptide forming an ?-helix structure and is positioned on an N-terminal side, a C block that includes a peptide forming an ?-helix structure and is positioned on a C-terminal side, and a B block that includes a peptide linking the A block and the C block by a covalent bond.

Abstract: A sheet feeder, which can be included in an image forming apparatus, includes a rotary body to contact and feed a recording medium to a downstream side along a sheet conveying path, a friction body disposed facing and contacting the rotary body with the sheet conveying path interposed therebetween, the friction body forming a separation nip region with the rotary body, a receiver to support the friction body at a position opposite to the separation nip region, and multiple projections to guide the recording medium toward the separation nip region. Each of the multiple projections extends toward the rotary body at respective axial ends of the rotary body and has a top face disposed upstream from the separation nip region in a sheet conveying direction between an outer circumferential surface of the rotary body and a surface of the friction body.

Abstract: A sheet feeding device, which is included in an image forming apparatus and includes a device attachment body, includes a sheet container configured to accommodate a sheet, a support configured to support a lower face of the sheet in the sheet container, a sheet width regulator configured to regulate a position of the sheet in a sheet width direction, a conveying force applier configured to apply a sheet conveying force in a sheet conveying direction to the sheet in the sheet container, and a sheet guide disposed above the sheet in the sheet container and configured to regulate movement of the sheet in an upper direction.

Abstract: A paper output tray, which can be included in a paper output unit in an image forming apparatus, includes a tray body, a paper support extension slidably attached to the tray body and arranged switchable between a stored state in which the paper support extension is stored in the tray body and an extended state in which the paper support extension is pulled out to extend from the tray body, and a stopper rotatably attached to the paper support extension and arranged switchable between a folded state in which the stopper is folded to the paper support extension and a standing state in which the stopper is raised from the paper support extension. With the paper support extension in the stored state and the stopper in the folded state, the stopper overlaps an outer surface of the tray body.

Abstract: A sheet feeder of a friction pad separation type, which can be included in an image forming apparatus, includes a feeder body, a rotary feed body, a separation body, a holder, and a leaf spring. The rotary feed body is disposed in the feeder body and feeds a recording medium along a sheet conveying direction. The separation body is fixed to the feeder body while facing the rotary feed body. The separation body separates the recording medium with the rotary feed body. The holder has a rotary shaft and holds the separation body while being rotatably supported by the rotary shaft. The leaf spring has a flexible deforming part that contacts an area adjacent to the rotary shaft and a line of action of a pressing force of the flexible deforming part passing close by the rotary shaft.

Abstract: A sheet feeding device includes a rotary feeder to contact a first side of a sheet to feed the sheet downstream along a feed passage; a friction pad disposed opposing the rotary feeder with the feed passage interposed between the rotary feeder and the friction pad to form a separation nip, the friction pad having a first side facing the separation nip and a second side opposite the first side of the friction pad; a holder disposed on the second side of the friction pad and having a first side holding the friction pad and a second side opposite the first side of the holder; a guide support disposed on the second side of the holder; and a pair of guides disposed on the guide support to contact a second side of the sheet facing the friction pad to raise the sheet from a surface of the friction pad.

Abstract: A sheet conveying device includes a holder, a friction member, a rotary conveyance member having an outer circumferential surface and forming a nip area between the outer circumferential surface thereof and the friction member, the rotary conveyance member configured to rotate while contacting the friction member, and separate and convey multiple sheet-like materials one by one at the nip area, and a pair of guides configured to lift an underside of each of the sheet-like materials at a portion facing the friction member, the pair of guides disposed upstream from the nip area in a sheet conveying direction, outside both ends in an axial direction of the rotary conveyance member, separate from the nip area from the axial direction of the rotary conveyance member, and being overlaid with the outer circumferential surface of the rotary conveyance member.

Abstract: A sheet feeder includes a feeding member to contact a sheet and feed the sheet downstream in a sheet conveyance direction, a friction pad disposed facing the feeding member to contact the feeding member, and a receiving table including a pad mount to hold a side of the friction pad opposite a nip between the friction pad and the feeding member. The friction pad includes a fixed range secured to the pad mount upstream from the nip and a movable range extending downstream the nip in the sheet conveyance direction. A first friction force of the pad mount to act on the movable range of the friction pad is smaller than a second friction force of the sheet to act on the movable range of the friction pad.

Abstract: A sheet feeder of a friction pad separation type, which can be included in an image forming apparatus, includes a feeder body, a rotary feed body, a separation body, a holder, and a leaf spring. The rotary feed body is disposed in the feeder body and feeds a recording medium along a sheet conveying direction. The separation body is fixed to the feeder body while facing the rotary feed body. The separation body separates the recording medium with the rotary feed body. The holder has a rotary shaft and holds the separation body while being rotatably supported by the rotary shaft. The leaf spring has a flexible deforming part that contacts an area adjacent to the rotary shaft and a line of action of a pressing force of the flexible deforming part passing close by the rotary shaft.

Abstract: A sheet feeding device, which is incorporated in an image forming apparatus, includes a sheet container that contains a sheet therein, an outer end part connectable to the sheet container, a sheet feeding member, a swing shaft, a sheet loading member supported by the swing shaft to swing according to an amount of sheets loaded on the loading surface, a rotary shaft, and a sheet amount indicator being rotatably supported by the rotary shaft and having a contact end contacting the sheet loading member swinging according to a remaining amount of sheets and a sheet amount display end moving in a given display range visible from the outside of the sheet feeding device. The sheet loading member has a sloped surface sloped to a loading surface of the loading member and disposed at a portion where the contact end of the sheet amount indicator contacts the loading surface.

Abstract: A sheet feeding device includes a rotary feeder to contact a first side of a sheet to feed the sheet downstream along a feed passage; a friction pad disposed opposing the rotary feeder with the feed passage interposed between the rotary feeder and the friction pad to form a separation nip, the friction pad having a first side facing the separation nip and a second side opposite the first side of the friction pad; a holder disposed on the second side of the friction pad and having a first side holding the friction pad and a second side opposite the first side of the holder; a guide support disposed on the second side of the holder; and a pair of guides disposed on the guide support to contact a second side of the sheet facing the friction pad to raise the sheet from a surface of the friction pad.

Abstract: A sheet feeder, which can be included in an image forming apparatus, includes a rotary body to contact and feed a recording medium to a downstream side along a sheet conveying path, a friction body disposed facing and contacting the rotary body with the sheet conveying path interposed therebetween, the friction body forming a separation nip region with the rotary body, a receiver to support the friction body at a position opposite to the separation nip region, and multiple projections to guide the recording medium toward the separation nip region. Each of the multiple projections extends toward the rotary body at respective axial ends of the rotary body and has a top face disposed upstream from the separation nip region in a sheet conveying direction between an outer circumferential surface of the rotary body and a surface of the friction body.

Abstract: A sheet feeder includes a feeding member to contact a sheet and feed the sheet downstream in a sheet conveyance direction, a friction pad disposed facing the feeding member to contact the feeding member, and a receiving table including a pad mount to hold a side of the friction pad opposite a nip between the friction pad and the feeding member. The friction pad includes a fixed range secured to the pad mount upstream from the nip and a movable range extending downstream the nip in the sheet conveyance direction. A first friction force of the pad mount to act on the movable range of the friction pad is smaller than a second friction force of the sheet to act on the movable range of the friction pad.

Abstract: A sheet discharger including a pair of rotary bodies to discharge a sheet to a discharge part by rotating while sandwiching the sheet and to hold the sheet, a part of which is discharged and exposed from a discharge exit of the sheet discharger, and a separation unit operatively connected to the pair of rotary bodies, including an operating part provided closer to the discharge exit than the pair of rotary bodies to support the sheet held by the pair of rotary bodies, that separates the pair of rotary bodies from each other by withdrawal of the sheet held by the pair of rotary bodies toward the discharge exit of the sheet discharger.

Abstract: A feeding device includes a paper feed tray, a detector on an image forming apparatus main body, a control member rotatably supported by the paper feed tray, and spacers. The detector includes movable pieces and contact points corresponding to the movable piece, and switches each contact point by the position of the corresponding movable piece. The control member includes a control surface formed on its outer circumferential surface with projecting and recessed portions. The projecting and recessed portions are disposed in a pattern corresponding to rotation angles in an area of the control surface facing the movable pieces. Controlling the positions of the movable pieces according to the pattern encodes paper size. Each movable piece is lined in the circumferential direction facing the control surface. The outer circumferential surface of the projecting portions is formed in a cylindrical surface shape centering around the rotational axis of the control member.

Abstract: A sheet feeding device, which is incorporated in an image forming apparatus, includes a sheet container that contains a sheet therein, an outer end part connectable to the sheet container, a sheet feeding member, a swing shaft, a sheet loading member supported by the swing shaft to swing according to an amount of sheets loaded on the loading surface, a rotary shaft, and a sheet amount indicator being rotatably supported by the rotary shaft and having a contact end contacting the sheet loading member swinging according to a remaining amount of sheets and a sheet amount display end moving in a given display range visible from the outside of the sheet feeding device. The sheet loading member has a sloped surface sloped to a loading surface of the loading member and disposed at a portion where the contact end of the sheet amount indicator contacts the loading surface.