Patents by Inventor Ikuo Iijima
Ikuo Iijima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4948900Abstract: Novel benzoxazole derivatives of the formula: ##STR1## wherein R is a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group, a substituted or unsubstituted cycloalkyl group or a substituted or unsubstituted heterocyclic group; Alk is single bond, a substituted or unsubstituted lower alkylene group, a lower alkenylene group or a lower alkynylene group; the group is a group of the formula: --CH.sub.2 -- or --CH.dbd., and a pharmaceutically acceptable salt thereof are disclosed. Said derivative (I) and a salt thereof are useful as therapeutic agents for diabetes.Type: GrantFiled: November 13, 1989Date of Patent: August 14, 1990Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Ikuo Iijima, Masakatsu Ozeki, Kunihito Okumura, Masanori Inamasu
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Patent number: 4897393Abstract: Novel benzoxazole derivative of the formula: ##STR1## wherein R is a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group, a substituted or unsubstituted cycloalkyl group or a substituted or unsubstituted heterocyclic group; Alk is single bond, a substituted or unsubstituted lower alkylene group, a lower alkenylene group or a lower alkynylene group; the group ##STR2## is a group of the formula: --CH.sub.2 -- or --CH.dbd., and a pharmaceutically aceptable salt thereof are disclosed. Said derivative (I) and a salt thereof are useful as therapeutic agents for diabetes.Type: GrantFiled: March 14, 1988Date of Patent: January 30, 1990Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Ikuo Iijima, Masakatsu Ozeki, Kunihito Okumura, Masanori Inamasu
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Patent number: 4882340Abstract: A novel benzofuran derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, a lower alkoxy group or a halogen atom, one of R.sup.2 and R.sup.3 is a lower alkyl group and the other is a lower alkyl group or a phenyl-lower alkyl group, or R.sup.2 and R.sup.3 combine together with adjacent nitrogen atom to form a heteromonocyclic group, Ring A is a substituted or unsubstituted phenyl group, Y is oxygen atom or sulfur atom and n is an integer of 2 or 3, or a pharmaceutically acceptable salt thereof is disclosed.The compound (I) or a pharmaceutically acceptable salt thereof has a potent inhibitory activity against reflective contractions of urinary bladder.Type: GrantFiled: September 2, 1988Date of Patent: November 21, 1989Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Ikuo Iijima, Masakatsu Ozeki, Yutaka Saiga, Tohru Ishizuka, Kunio Nosaka
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Patent number: 4829067Abstract: Novel benzo-furan(or -thiophene) derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, a lower alkyl group, a cycloalkyl group, a phenyl-lower alkyl group or a substituted or unsubstituted phenyl group, R.sup.2 is hydrogen atom, a lower alkyl group, an acyl group or phenyl group, R.sup.3 is hydrogen atom, a halogen atom, nitro group, a lower alkoxy group, amino group or an acylamino group, R.sup.4 is a group of the formula: ##STR2## A is a lower alkylene group optionally substituted with hydroxy group, B is single bond or a lower alkylene group, one of R.sup.5 and R.sup.6 is hydrogen atom or a lower alkyl group and the other is a lower alkyl group or a phenyl-lower alkyl group, or R.sup.5 and R.sup.6 combine together with adjacent nitrogen atom to form a heteromonocyclic group, R.sup.7 is a lower alkyl group, X is oxygen atom or sulfur atom, Y is oxygen atom, imino group, a lower alkylimino group or a phenyl-lower alkylimino group and a salt thereof are disclosed.Type: GrantFiled: December 2, 1987Date of Patent: May 9, 1989Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Ikuo Iijima, Masakatsu Ozeki, Yutaka Saiga, Tohru Ishizuka, Kunio Nosaka
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Patent number: 4824833Abstract: Novel benzoxazine derivative of the formula: ##STR1## wherein R.sup.1 is phenyl group or a substituted thiazolyl group; R.sup.2 is hydrogen atom or a lower alkyl group; Q is single bond or a lower alkylene group, or a salt thereof are disclosed. Said derivative (I) and a salt thereof are useful as therapeutic agents for diabetes.Type: GrantFiled: March 14, 1988Date of Patent: April 25, 1989Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Ikuo Iijima, Masakatsu Ozeki, Kunihito Okumura, Masanori Inamasu
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Patent number: 4663319Abstract: Novel thioketene derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, an alkyl group, a lower alkenyl group, a phenyl group or a group of the formula: --B--Y;Y is a nitrogen-containing monocyclic heterocyclic group or a substituted or unsubstituted phenyl group;B is a straight or branched lower alkylene group;R.sup.2 and R.sup.3 are both a lower alkyl group or are combined together to form a group of the formula: --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--;R.sup.4 is hydrogen atom, a lower alkyl group or a (lower alkoxy)carbonyl group;A is a group of the formula: --(CH.sub.2).sub.n -- or --CH(COOR.sup.5)--;n is an integer of 0, 1 or 2 andR.sup.5 is a lower alkyl group,are disclosed. The compound (I) is useful as an agent for treating and protecting various liver diseases.Type: GrantFiled: January 7, 1985Date of Patent: May 5, 1987Assignee: Tanabe Seiysku Co., Ltd.Inventors: Ikuo Iijima, Koichi Homma, Yutaka Saiga, Yuzo Matsuoka, Mamoru Matsumoto
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Patent number: 4628057Abstract: Novel tetrahydro-.beta.-carboline derivatives of the formula: ##STR1## wherein R.sup.1 is carboxyl, a lower alkoxycarbonyl, carbamoyl, an N,N-di-lower alkylcarbamoyl, an N-(phenyl-substituted lower alkylidenamino)carbamoyl, a [N,N-di(lower alkyl)amino]-lower alkyl, or a nitrogen-containing monocyclic heterocyclic group;R.sup.2 is hydrogen atom, a lower alkyl, or a hydroxy-lower alkyl group, or R.sup.2 is combined with R.sup.1 to form a group: --CO--O--CH.sub.2 --;R.sup.3 is hydrogen atom, a lower alkyl, a phenyl-lower alkyl, or a group: --CSS--R.sup.4 ;R.sup.4 is hydrogen atom, an alkyl, or a group: --(CH.sub.2).sub.n Y.sup.1 ;n is 0, 1 or 2,Y.sup.Type: GrantFiled: October 30, 1984Date of Patent: December 9, 1986Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Ikuo Iijima, Yutaka Saiga, Toshikazu Miyagishima, Yuzo Matsuoka, Mamoru Matsumoto
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Patent number: 4625032Abstract: Tetrahydro-.beta.-carboline derivative of the formula: ##STR1## wherein R.sup.2 is lower alkyl, and either (A)R.sup.1 is hydroxymethyl or carboxy,R.sup.3 and R.sup.4 are both hydrogen, andX is halogen, lower alkyl, lower alkoxy, hydroxy or benzyloxy; or(B)R.sup.1 is hydrogen, carboxy-lower alkyl or a group of the formula: --CH.sub.2 OY,Y is lower alkyl, lower alkanoyl or an oxygen-containing monocyclic heterocyclic group,R.sup.3 is hydrogen, hydroxy-lower alkyl or carboxy,R.sup.4 is hydrogen or hydroxy-lower alkyl, andX is hydrogen,or a salt thereof, which has excellent activities for alleviating, curing and preventing hepatic damages and is useful as a therapeutic or prophylactic agent for hepatic diseases.Type: GrantFiled: June 4, 1985Date of Patent: November 25, 1986Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Ikuo Iijima, Yutaka Saiga, Toshikazu Miyagishima, Yuzo Matsuoka, Mamoru Matsumoto
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Patent number: 4612317Abstract: Tetrahydro-.beta.-carboline derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, a lower alkyl group, a cycloalkyl group, phenyl group or a hydroxy-substituted lower alkyl group, R.sup.2 is hydrogen atom, an alkyl group, or a group of the formula: --(CH.sub.2).sub.m Y, Y is thienyl or a substituted or unsubstituted phenyl group, and m and n are an integer of 1 or 2, which have excellent alleviating, curing and preventing hepatic damages and are useful as a therapeutic or prophylactic agent for hepatic diseases, and a process for the preparation of said compounds.Type: GrantFiled: May 18, 1984Date of Patent: September 16, 1986Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Ikuo Iijima, Yutaka Saiga, Toshikazu Miyagishima, Yuzo Matsuoka, Mamoru Matsumoto
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Patent number: 4438035Abstract: A benzothiazepine derivative of the formula: ##STR1## wherein R is hydrogen or acetyl, is prepared by condensing a compound of the formula: ##STR2## wherein R is the same as defined above, with 2-(diamethylamino)ethyl halide (i) in the presence of potassium hydroxide in acetone; or (ii) in the presence of potassium carbonate in acetone, lower alkyl acetate, a mixture of acetone and water or a mixture of lower alkyl acetate and water.Type: GrantFiled: December 1, 1982Date of Patent: March 20, 1984Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Mitsunori Gaino, Ikuo Iijima, Shigeru Nishimoto, Kuichiro Ikeda, Tokuo Fujii