Abstract: A workpiece having a first constant diameter portion, a tapered reduced-diameter portion, a concave portion, a tapered increased-diameter portion, and a second constant diameter portion is formed by machining the tapered reduced-diameter portion, and then machining the tapered increased-diameter portion and the concave portion.

Abstract: A method of forming a hollow curled portion on a hollow body, the curled portion being oriented from one end to the other end of the hollow body. The method includes a bending step of curving an end of the hollow body toward another end of the hollow body, thereby forming a curled portion, an ironing step of ironing the curled portion with a die, and a recurving step of stopping the die from ironing the curled portion and allowing the curled portion to recurve under its own resiliency in a direction opposite to the direction in which the end of the hollow body has been curved. The ironing step and the recurving step are repeated.

Abstract: The present invention relates to a Lactobacillus pentosus strain FERM BP-10958, a method for producing fermented food or drink with a fermentation process using the lactic acid bacteria, and fermented food or drink produced by fermentations using the lactic acid bacteria.

Abstract: A workpiece having a first constant diameter portion, a tapered reduced-diameter portion, a concave portion, a tapered increased-diameter portion, and a second constant diameter portion is formed by machining the tapered reduced-diameter portion, and then machining the tapered increased-diameter portion and the concave portion.

Abstract: A method of forming a hollow curled portion on a hollow body, the curled portion being oriented from one end to the other end of the hollow body. The method includes a bending step of curving an end of the hollow body toward another end of the hollow body, thereby forming a curled portion, an ironing step of ironing the curled portion with a die, and a recurving step of stopping the die from ironing the curled portion and allowing the curled portion to recurve under its own resiliency in a direction opposite to the direction in which the end of the hollow body has been curved. The ironing step and the recurving step are repeated.

Abstract: Provided is an irinotecan formulation capable of supporting irinotecan and/or a salt thereof in a closed vesicle carrier at a high concentration and existing in blood for a long period of time by dramatically improved retentivity in blood compared to a conventionally known irinotecan liposome formulation. That is, an irinotecan formulation including a closed vesicle formed by a lipid membrane, in which irinotecan and/or a salt thereof is encapsulated at a concentration of at least 0.07 mol/mol (drug mol/membrane total lipid mol). There is an ion gradient between an inner aqueous phase and an outer aqueous phase in the irinotecan formulation. The closed vesicle is preferably liposome, in which only the outer surface of the liposome is preferably modified with a surface-modifying agent containing a hydrophilic polymer.

Abstract: A method of manufacturing a wheel rim by bringing end faces of a workpiece into abutment against each other to form a hollow cylindrical body and forming a circumferential recess which is depressed from an outer circumferential wall of said hollow cylindrical body toward an inner circumferential wall thereof, including providing protrusions disposed near ends of a joined area of the hollow cylindrical body and extending in a joining direction, and then pressing the outer circumferential wall of the hollow cylindrical body to form the recess.

Abstract: The present invention aims at providing a slightly water-soluble camptothecin liposome preparation with an excellent retention in blood for a drug, which can stably hold a slightly water-soluble camptothecin compound for a long period of time, whereby hydrolysis of an ?-hydroxylactone ring in blood is suppressed and the slightly water-soluble camptothecin compound is kept in a structure in which the ring is not opened and which makes the compound effective as an antitumor-active drug, and, moreover, the liability of the drug to leave a liposome is advantageously reduced, so that it is possible to maintain the drug concentration in plasma for a long period of time after administration. This object is achieved by the liposome preparation as described in the specification.

Abstract: Provided is an irinotecan formulation capable of supporting irinotecan and/or a salt thereof in a closed vesicle carrier at a high concentration and existing in blood for a long period of time by dramatically improved retentivity in blood compared to a conventionally known irinotecan liposome formulation. That is, an irinotecan formulation including a closed vesicle formed by a lipid membrane, in which irinotecan and/or a salt thereof is encapsulated at a concentration of at least 0.07 mol/mol (drug mol/membrane total lipid mol). There is an ion gradient between an inner aqueous phase and an outer aqueous phase in the irinotecan formulation. The closed vesicle is preferably liposome, in which only the outer surface of the liposome is preferably modified with a surface-modifying agent containing a hydrophilic polymer.

Abstract: A rim (10) is produced by a production process including a step (A) of bending a workpiece (11) to bring end faces of the workpiece into contact with each other, a step (B) of forming a circular cylinder body (12) by joining the end faces brought to be in contact with each other, a step (C) of inspecting a joint portion (13) of the circular cylinder body (12), a step (D) of forming a drop portion (16), subsiding toward the inner peripheral wall (15) side, in an outer peripheral wall (14) of the circular cylinder body (12), a by bending both end portions of the circular cylinder body (12), a step (F) of forming hump portions (20) by pressing the circular cylinder body (12) from the inner peripheral wall (15) side to raise the outer peripheral wall (14), and a step (G) for forming a valve hole (22) and water drain holes (24) in the drop portion (16) and the curl portions (18). The rim (10) and a disk (102) that is separately produced are welded to form a wheel (122).

Abstract: A method for manufacturing a drink made from beans as a raw material and a solid fermented food. It is characterized in that it comprises the steps of: preparing a stabilized suspension by homogenization-treating an aqueous slurry of whole grain-mash of beans once or a plurality of times using a homogenizer; denaturing protein by adding a coagulant and/or a pH adjustor to the stabilized suspension; and performing the dispersing treatment for making the relevant protein denaturation raw material dispersed by a physical dispersing means. In a solid fermented food, it comprises a step of fermenting for fermenting/solidifying by adding a lactic bacterium starter following the step of performing a homogenization treatment, and manufactures it via the step of maturating it if it is necessary.

Abstract: Both ends of a metal cylindrical member are formed with rectangular cross section normal curls which are doubly bent in the radial direction of the cylindrical member by plastic working. With this, it is possible to form a rim directly from the cylindrical member and to easily produce a two-piece wheel. A barrel of the metal cylindrical member (2) is subjected to drop center portion working. Then, both ends (3) of the cylindrical member (2) are expanded by plastic working, and the expanded ends (3) are formed into normal curls (4) having rectangular cross sections by normal curl working (method 1). Alternatively, the expanded ends (3) are formed into curls (4) having circular cross sections by curl working, and the curls (4) are finished to a normal shape having a rectangular cross section by shaping and precision-enhancing working (method 2).

Abstract: The present invention provides a highly sensitive immunoassay system for estrogens, which utilizes as a labeled compound a biotinylated estradiol derivative of the formula (1) wherein one of R1 and R2 is hydrogen and the other is a group represented by wherein R3s are the same or different and represent an arginine residue or a lysine residue, x is 0 or 1, y is an integer from 1 to 5, and z is an integer from 1 to 3.

Abstract: The present invention provides an immunoassay for phthalic acid esters, which comprises measuring the phthalic acid esters contained in a sample using an antibody produced with a conjugate of a carrier protein and a phthalic acid ester derivative represented by the formula wherein R1 and R2 may be the same or different and are hydrogen, alkyl, cycloalkyl or phenylalkyl, with the proviso that both of R1 and R2 are not hydrogen; m is an integer from 1 to 5; and Y is amino or carboxyl.

Abstract: The present invention provides a highly sensitive immunoassay system for estrogens, which utilizes as a labeled compound a biotinylated estradiol derivative of the formula (1) 1

Abstract: Electronic parts, such as an inductor, of improved connectivity between magnetic and conductive materials are made by sintering magnetic material under a condition in which no accumulation is developed, by forming a hollow-core of a shape different from an external shape of said conductive material through said magnetic material to be molded by an extrusion-molding means while inserting said magnetic material into said hollow-core, or by providing an erasable means to be removed by a heat treatment in said conductive material and conducting extrusion molding so as to embed said conductive material into said magnetic material, said erasable means being removed during a sintering treatment to form a space between said conductive material and said magnetic material, and a method for making same.

Abstract: Electronic parts such as an inductor of improved connectivity between magnetic and conductive materials made by sintering the magnetic material under a condition where no accumulation is developed, by forming a hollow-core of a shape different from an external shape of said conductive material through said magnetic material to be molded by an extrusion-molding means while inserting said magnetic material into said hollow-core, or by providing an erasable means to be removed by a heat treatment in said conductive material and conducting extrusion molding so as to embed said conductive material into said magnetic material, said erasable means being removed during a sintering treatment to form a space between said conductive material and said magnetic material, and a method for making same.

Abstract: Electronic parts, such as tip inductors may be formed by molding a first molded component as a core by kneading a magnetic material, such as ferrite powder, and a binder, such as resins, spirally winding a conductive material on the periphery of the first molded component with a constant winding pitch, molding a second molded component by covering the periphery of the conductive material as well as the first molded component with a kneaded mixture of a magnetic material, such as ferrite powder, and a binder, such as resins, to form a cover component, integrally sintering both of the first molded component and the cover component, cutting the second molded component into tips of desired length, to thereby partially expose the conductive material out of both end surfaces of the second molded component. Further, terminal electrodes may be fixed to said conductive material at each of the end surfaces of the second molded component where said conductive material of said tips is partially exposed.

Abstract: A complex circuit component for a video signal circuit in a television receiver set has a single substrate, on which a first ceramic trap for removing speech carrier wave together with an inductor for that trap, a second trap for removing color subcarrier wave, and a delay circuit coupled with output of said second trap are mounted. The capacitors for those circuits are implemented by a pair of conductive patterns deposited on front surface and rear surface of the substrate. The capacitor for said first ceramic trap is subject to trimming so that the characteristics of the trap is adjustable.

Abstract: Immunostimulating agent for inhibiting tumors comprising Lactobacillus casei YIT 9018 and methods for treating and/or preventing tumor growth.