Abstract: To provide a microneedle array which includes a sheet and needles, improves transfer of a medicament into the blood, and is capable of achieving high drug efficacy. Provided is a microneedle array including: a sheet; and a plurality of needles present on the upper surface of the sheet, in which the needles contain a water-soluble polymer and a medicament, the sheet contains a water-soluble polymer, and the administration is performed such that 20 ?m?L2?L?L1 is satisfied, here, L represents the length of a needle, L1 represents the length of a needle tip region, which contains 90% of the total medicament in the microneedle array, from the needle tip, L2 represents the average remaining length of the needle after administration using the microneedle array, and the unit of L, L1, and L2 is ?m.

Abstract: A method for making a positive photosensitive planographic printing plate including of a base having formed thereon in this order an undercoat layer and an image recording layer, wherein the undercoat layer is obtained by applying an undercoat layer solution containing a solvent and an acrylic resin having an alkali-soluble group, followed by drying the coating, the image recording layer contains a novolac resin and an infrared absorbing agent, and the applied undercoat layer solution is dried in an undercoat layer drying step which includes a steam-containing hot air drying step using steam-containing hot air having a temperature of 90° C. to 200° C., and a relative humidity of 8% to 70%.

Abstract: According to a method of preparing a lithographic printing plate substantially comprising a step of imagewise exposing a negative lithographic printing plate precursor having an image-recording layer containing (i) a sensitizing dye, (ii) a photopolymerization initiator, (iii) an addition polymerizable compound having an ethylenically unsaturated double bond and (iv) a binder polymer on a support and a step of processing the exposed lithographic printing plate precursor with an aqueous solution containing a carbonate ion, a hydrogen carbonate ion and a surfactant, the processing property is improved, a printing plate free from the tackiness on the surface thereof can be provided, even when the printing plate is stored after the development until printing, deterioration of the printing durability does not occur, and it becomes possible to conduct one solution development with a weak alkaline processing solution.

Abstract: To provide a method of preparing a lithographic printing plate which is safe, exhibits excellent developing property and processing ability, and enables processing with one solution by processing after image exposure, a negative lithographic printing plate precursor having an image-recording layer containing (i) a sensitizing dye, (ii) a photopolymerization initiator, (iii) an addition polymerizable compound having an ethylenically unsaturated double bond, and (iv) a binder polymer on a hydrophilic support with an aqueous solution containing a carbonate ion, a hydrogen carbonate ion and a water-soluble polymer compound.

Abstract: An immersion type automatic developing apparatus for a lithographic printing plate in which removal of a non-image area is conducted in a state where a lithographic printing plate precursor having on a support an image-recording layer exposed imagewise is immersed in a developing bath filled with an aqueous solution containing a carbonate ion, a hydrogen carbonate ion and a water-soluble polymer compound, wherein a developer composed of the aqueous solution is circulated between the immersion type developing bath forming a processing pass line and an external tank provided outside the processing path line so as to keep constant a liquid level of the immersion type developing bath.

Abstract: A negative-working photopolymerization type photosensitive lithographic printing plate precursor for exposing with laser, includes: a hydrophilic support; at least one photopolymerizable photosensitive layer; and a protective layer, provided in this order, wherein the photopolymerizable photosensitive layer contains a sensitizing dye, a dye or pigment capable of absorbing light having a wavelength of a laser emission wavelength ±50 nm, which is different from the sensitizing dye; and a photopolymerization initiator.

Abstract: A method for preparing a lithographic printing plate, includes: exposing imagewise a lithographic printing plate precursor including a hydrophilic support and an image-recording layer containing a sensitizing dye, a polymerization initiator, an addition polymerizable compound having an ethylenically unsaturated double bond and a binder polymer; and processing the imagewise exposed lithographic printing plate precursor in a state where the imagewise exposed lithographic printing plate precursor is immersed in a developing tank holding an aqueous solution having pH of 8.5 to 10.8 and containing a low molecular weight hydroxycarboxylate ion, a pH buffer agent and a surfactant with circulation of the aqueous solution between the developing tank and an external tank provided outside a processing path line including the developing tank so as to keep constant a liquid level of the aqueous solution in the developing tank.

Abstract: The present invention provides a method for producing a safe lithographic printing plate that exhibits an excellent developability and an excellent processing performance. The present invention also provides a method for producing a lithographic printing plate which enables single liquid processing and in which the obtained plate does not exhibit an impaired printing durability, does not exhibit a decline in printing durability even when the printing plate is stored after development before printing, and can inhibit the appearance of fingerprint scumming. A method of producing a lithographic printing plate is provided comprising: imagewise photoexposing a negative-working lithographic printing plate precursor that has an image-recording layer containing the (i), (ii), (iii), and (iv) described below on a hydrophilic support; and treating thereafter the imagewise-photoexposed negative-working lithographic printing plate precursor with an aqueous solution that has a pH of 8.5 to 10.

Abstract: A planographic printing plate precursor comprising a hydrophilic support having a surface roughness (Ra) in a range of from 0.45 to 0.60, and, on the support, a recording layer containing a phenolic resin, an infrared absorber and a polymer having at least one selected from the group consisting of a structural unit represented by the following formula (I) and a structural unit represented by the following formula (II). In the Formulae (I) and (II), R1 represents a hydrogen atom or an alkyl group; z represents —O— or —NR2— wherein R2 represents a hydrogen atom, an alkyl group, an alkenyl group or an alkynyl group; Ar1 and Ar2 each independently represent an aromatic group, and at least one of Ar1 and Ar2 represents a heteroaromatic group; and a and b each independently represent 0 or 1.

Abstract: A method for preparing a lithographic printing plate includes: exposing a lithographic printing plate precursor including a hydrophilic support, a photosensitive layer containing (A) a sensitizing dye having an absorption maximum in a wavelength range of from 350 to 450 nm represented by the formula (I) or (II) as defined herein, (B) a polymerization initiator, (C) a polymerizable compound and (D) a binder polymer and a protective layer in this order with laser of from 350 to 450 nm; and removing the protective layer and an unexposed area of the photosensitive layer in the presence of a developer having pH of from 9 to 11 and containing an alkali agent, a surfactant and a water-soluble polymer compound by an automatic processor.

Abstract: A method for preparing a lithographic printing plate includes: exposing a lithographic printing plate precursor including a hydrophilic support, a photosensitive layer containing (A) a sensitizing dye having an absorption maximum in a wavelength range of from 350 to 450 nm represented by the formula (I) as defined herein, (B) a polymerization initiator, (C) a polymerizable compound and (D) a binder polymer and a protective layer in this order with laser of from 350 to 450 nm; and removing the protective layer and an unexposed area of the photosensitive layer in the presence of a developer having pH of from 9 to 11 and containing a carbonate ion, a hydrogen carbonate ion, a surfactant and a water-soluble polymer compound by an automatic processor.

Abstract: A dot pattern with a plurality of pixels representing a two-dimensional image is formed on a printing plate material by applying laser beams, which are turned on and off for each pixel depending on dot pattern data, to the printing plate material in a main scanning direction, while the laser beams are moved in an auxiliary scanning direction that is orthogonal to the main scanning direction. A threshold matrix having an array of thresholds is obtained for generating a dot where the degree of a variation of the dot periphery length in a main scanning direction is smaller, i.e., a dot where the dot periphery length in the main scanning direction has a smaller standard deviation.

Abstract: A normalization threshold side size Nr which serves as an index indicative of how many times the pattern frequency r is repeated in one threshold matrix is defined as Nr=N×r/R where N represents a size of one side of the threshold matrix as the number of pixels, and the threshold array of the threshold matrix is determined such that the normalization threshold side size Nr is of an value greater than 65.

Abstract: The planographic printing plate precursor according to the present invention includes: a support; and a photosensitive layer provided on the support and containing a polymer having the structural unit represented by the following Formula (1) and an acid coloring colorant represented by the following Formula (2). The planographic printing plate precursor is superior in each of chemical resistance, solubilization discrimination, and image reproducibility. In Formula (1) above, X represents a bivalent connected group; R1 represents an alkyl or aryl group; and x is 0 or 1.

Abstract: A method for making a positive photosensitive planographic printing plate including of a base having formed thereon in this order an undercoat layer and an image recording layer, wherein the undercoat layer is obtained by applying an undercoat layer solution containing a solvent and an acrylic resin having an alkali-soluble group, followed by drying the coating, the image recording layer contains a novolac resin and an infrared absorbing agent, and the applied undercoat layer solution is dried in an undercoat layer drying step which includes a steam-containing hot air drying step using steam-containing hot air having a temperature of 90° C. to 200° C., and a relative humidity of 8% to 70%.

Abstract: An infrared-sensitive planographic printing plate precursor including: a support; a recording layer capable of forming an image through infrared irradiation provided on or above one surface of the support, the recording layer containing a resin, which is water-insoluble and alkali-soluble, and an infrared absorbent; and an organic polymer layer provided on or above the other surface of the support, wherein when the organic polymer layer is formed, a solvent is used, and the total amount of solvent remaining in the organic polymer layer is 10 mg per gram of the organic polymer or less is provided.

Abstract: A negative-working photopolymerization type photosensitive lithographic printing plate precursor for exposing with laser, includes: a hydrophilic support; at least one photopolymerizable photosensitive layer; and a protective layer, provided in this order, wherein the photopolymerizable photosensitive layer contains a sensitizing dye, a dye or pigment capable of absorbing light having a wavelength of a laser emission wavelength ±50 nm, which is different from the sensitizing dye; and a photopolymerization initiator.

Abstract: A positive planographic printing plate precursor includes a support having disposed thereon a lower thermosensitive layer containing a water-insoluble but alkali-soluble polymer compound and an upper thermosensitive layer containing a water-insoluble but alkali-soluble polymer compound, with alkali-solubility increasing under heat, wherein (i) both the upper thermosensitive layer and the lower thermosensitive layer contain an IR absorbing dye, with the ratio of the IR absorbing dye concentration in the upper thermosensitive layer to the IR absorbing dye concentration in the lower thermosensitive layer is 1.6 to 10.0, and/or (ii) the upper thermosensitive layer and the lower thermosensitive layer contain different IR absorbing dyes, and/or (iii) at least one of the upper thermosensitive layer and the lower thermosensitive layer contains an IR absorbent having, in one molecule, at least two chromophoric groups that absorb IR light, with the chromophoric groups bonding to each other via a covalent bond.

Abstract: An image recording material of the present invention comprises an anodized aluminum support, an intermediate layer containing a polymer having a carboxylic acid group in a side chain thereof and formed on the aluminum support, and a photosensitive layer containing at least 50% by weight or more of novolak type phenol resin and a photothermal conversion agent and recordable by IR laser beam. A planographic printing plate excellent in printing durability can be obtained by subjecting the image recording material imagewise to IR laser exposure treatment and to development treatment, and then heating the image recording material at 150 to 300° C.

Abstract: A positive type photosensitive image-forming material for use with an infrared laser is provided. The material includes a substrate, a layer (A) containing not less than 50% by weight of a copolymer which contains, as a copolymerization component, not less than 10% by mol of at least one of the following monomers (a-1) to (a-3), wherein (a-1) is a monomer having in the molecule a sulfonamide group wherein at least one hydrogen atom is linked to a nitrogen atom, (a-2) is a monomer having in the molecule an active imino group represented by the following general formula (I): and (a-3) is a monomer selected from acrylamide, methacrylamide, acrylate, methacrylate and hydroxystyrene, which respectively have a phenolic hydroxyl group; and a layer (B) containing not less than 50% by weight of an aqueous alkali solution-soluble resin having a phenolic hydroxyl group. The layer (A) and the layer (B) are laminated on the substrate in that order.