Patents by Inventor Ikuo Matsukuma

Ikuo Matsukuma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6H-pyrazolo-[4,5,1-d,e]acridin-6-one derivatives having anit-tumor activity
    Patent number: 5079358
    Abstract: Novel pyrazoloacridone compounds represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof have an excellent anti-tumor activity.
    Type: Grant
    Filed: June 14, 1989
    Date of Patent: January 7, 1992
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Toru Sugaya, Yukiteru Mimura, Yasushi Shida, Yutaka Osawa, Ikuo Matsukuma, Shiro Akinaga, Makoto Morimoto
  • Mitomycin compounds having useful anti-tumor activity
    Patent number: 4863935
    Abstract: Mitomycin derivatives having potent anti-tumor activity against solid sarcoma 180 tumors and lymphocytic leukemia P-388 tumors.
    Type: Grant
    Filed: December 11, 1987
    Date of Patent: September 5, 1989
    Assignee: Kyowa Hakko Kogyo K.K.
    Inventors: Yasushi Shida, Tokuyuki Kuroda, Ikuo Matsukuma, Makoto Morimoto, Tadashi Ashizawa
  • Optically active carbacephems
    Patent number: 4755596
    Abstract: Disclosed are optically active acylated cephalosporin analogs which are useful as antibacterial agents and methods for preparing such compounds.
    Type: Grant
    Filed: October 21, 1986
    Date of Patent: July 5, 1988
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tadashi Hirata, Yukio Hashimoto, Takehiro Ogasa, Shigeru Kobayashi, Ikuo Matsukuma, Kazuo Kimura
  • Optically active 3-halo carbacephems
    Patent number: 4734494
    Abstract: Optically active cephalosporin analogs are produced by optically selective deacylation of an optically inactive acylated analog. The compounds are useful as intermediates in the preparation of optically active acylated antimicrobial agents.
    Type: Grant
    Filed: November 6, 1986
    Date of Patent: March 29, 1988
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tadashi Hirata, Yukio Hashimoto, Ikuo Matsukuma, Shigeo Yoshiie, Seigo Takasawa
  • 3-position halogenated cephalosporin analogs and pharmaceutical compositions
    Patent number: 4708956
    Abstract: Novel cephalosporin analogs are disclosed which have antibacterial activity. Methods for producing the compounds are also disclosed.
    Type: Grant
    Filed: August 18, 1986
    Date of Patent: November 24, 1987
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tadashi Hirata, Ikuo Matsukuma, Shigeo Yoshiie, Kiyoshi Sato, Yoichi Ohashi
  • Treating convulsions with dihydrouracil derivatives
    Patent number: 4588729
    Abstract: Offered is an anticonvulsive composition which comprises an effective amount of a dihydrouracil derivative represented by the formula: ##STR1## [wherein one of A and B is ##STR2## (wherein Y.sub.1, Y.sub.2 and Y.sub.3 are hydrogen atoms, lower alkyl groups, halogen atoms, nitro groups, amino groups, carboxyl groups, lower alkoxycarbonyl groups or trifluoromethyl groups), a naphthyl group or a diphenylmethyl group, and the other is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a cyclopentyl group, a cyclohexyl group or ##STR3## (wherein Z.sub.1, Z.sub.2 and Z.sub.3 are hydrogen atoms, lower alkyl groups, halogen atoms or trifluoromethyl groups), R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms or lower alkyl groups, and X is an oxygen atom or a sulfur atom] and at least one pharmaceutically acceptable carrier.
    Type: Grant
    Filed: May 16, 1985
    Date of Patent: May 13, 1986
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Masayuki Teranishi, Chikara Murakata, Ikuo Matsukuma, Katsuichi Shuto, Shunji Ichikawa
  • Process for producing optically active cephalosporin analogs
    Patent number: 4335211
    Abstract: Disclosed are optically active acylated cephalosporin analogs which are useful as antibacterial agents and methods for preparing such compounds.
    Type: Grant
    Filed: November 13, 1980
    Date of Patent: June 15, 1982
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yukio Hashimoto, Seigo Takasawa, Tadashi Hirata, Ikuo Matsukuma, Shigeo Yoshiie
  • Process for producing cephalosporin analogs
    Patent number: 4332896
    Abstract: Optically active cephalosporin analogs are produced by an optically selective acylation reaction. The reaction is carried out in the presence of a microbial enzyme which catalyzes the selective optical acylation. The products thus obtained are useful as antibacterial agents.
    Type: Grant
    Filed: April 14, 1980
    Date of Patent: June 1, 1982
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yukio Hashimoto, Kazuo Kimura, Tadashi Hirata, Takehiro Ogasa, Shigeru Kobayashi, Ikuo Matsukuma
  • Process for producing optically active cephalosporin analogs
    Patent number: 4316958
    Abstract: Optically active cephalosporin analogs are produced by optically selective deacylation of an optically inactive acylated analog. The compounds are useful as intermediates in the preparation of optically active acylated antimicrobial agents.
    Type: Grant
    Filed: February 7, 1980
    Date of Patent: February 23, 1982
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tadashi Hirata, Yukio Hashimoto, Takehiro Ogasa, Shigeru Kobayashi, Ikuo Matsukuma, Kazuo Kimura
  • Process of producing optically active cephalosporin analogs by enzyme selective deacylation
    Patent number: 4302541
    Abstract: Optically active cephalosporin analogs are produced by optically selective deacylation of an optically inactive acylated analog. The compounds are useful as intermediates in the preparation of optically active acylated antimicrobial agents.
    Type: Grant
    Filed: November 13, 1980
    Date of Patent: November 24, 1981
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tadashi Hirata, Yukio Hashimoto, Ikuo Matsukuma, Shigeo Yoshiie, Seigo Takasawa
  • Agents for and method of modifying citrus fruit
    Patent number: 4217130
    Abstract: Novel compounds are disclosed which are useful as agents capable, when applied to citrus tree, of modifying the metabolism and organic acid content of the citrus fruit.
    Type: Grant
    Filed: October 24, 1978
    Date of Patent: August 12, 1980
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Teruyuki Tsuruta, Masanobu Kawai, Ikuo Matsukuma, Masayuki Teranishi, Nobuhiro Nakamizo
  • Phenylalanine derivatives
    Patent number: 4138485
    Abstract: This invention relates to certain derivatives of phenylalanine having interesting pharmaceutical properties, in particular, a lipid-lowering activity.
    Type: Grant
    Filed: February 24, 1977
    Date of Patent: February 6, 1979
    Assignee: Kyowa Hakko Kogyo Kabushiki Kaisha
    Inventors: Nobuhiro Nakamizo, Masayuki Teranishi, Ikuo Matsukuma, Katsuichi Shuto, Koji Yamada