Abstract: The present invention provides an industrial method production of silodosin, which is useful for a therapeutic agent for dysuria associated with benign prostatic hyperplasia. The production of silodosine is characterized by mixing 3-{7-cyano-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)-phenoxy]ethyl}amino]propyl]-2,3-dihydro-1H-indol-1-yl}-propyl benzoate and oxalic acid to yield the oxalate, subsequently hydrolyzing the oxalate salt to yield 1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino]propyl]-2,3-dihydro-1H-indole-7-carbonitrile and hydrolyzing the same, and manufacturing intermediates used therefore.

Abstract: The present invention provides an industrial method production of silodosin, which is useful for a therapeutic agent for dysuria associated with benign prostatic hyperplasia. The production of silodosine is characterized by mixing 3-{7-cyano-5-[(2R)-2-({(2-[2-(2,2,2-trifluoroethoxy)-phenoxy]ethyl}amino]propyl]-2,3-dihydro-1H-indol-1-yl}-propyl benzoate and oxalic acid to yield the oxalate, subsequently hydrolyzing the oxalate salt to yield 1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino]propyl]-2,3-dihydro-1H-indole-7-carbonitrile and hydrolyzing the same, and manufacturing intermediates used therefore.

Abstract: A low-noise output buffer circuit of this invention comprises a P-channel MOSFET having a source connected to a power source potential, for outputting the power source potential according to a first input signal, an N-channel MOSFET having a source connected to a ground potential, for outputting the ground potential according to a second input signal, a bipolar transistor having a collector connected to the power source potential, an emitter connected to an output terminal and a base connected to the drain of the P-channel MOSFET, and a diode having a cathode connected to the drain of the N-channel MOSFET and an anode connected to the base of the NPN bipolar transistor.

Abstract: A semiconductor device comprises a first pad region applied with a first potential, a first line led from the first pad region and connected to a first circuit, a second pad region integrated with the first pad region and applied also with the first potential, and a second line led from the second pad region connected to a second circuit and overlapped with the first line.

Abstract: A retriggerable multivibrator is disclosed which comprises a first delay circuit connected for delaying an input signal a predetermined time, a second delay circuit connected to receive an output of the first delay circuit and having a enable or disable function, a flip-flop circuit connected to be set or reset in accordance with an input signal and output signal from the second delay circuit, and a control circuit for detecting a subsequent input signal within a predetermined delay time to enable or disable the second delay circuit.

Abstract: A voltage controlled oscillator comprises a phase locked loop section and a voltage controlled oscillator section. The phase locked loop section is coupled with an input signal at a reference frequency and a reference potential, and performs a signal feedback control so as to obtain a constant delay time of a first variable delay circuit contained in the phase locked loop section. The voltage controlled oscillator section controls a delay time of a second variable delay circuit in a ring oscillator by a control input voltage and an output voltage of a low-pass filter contained in the phase locked loop section, and produces a signal oscillating at a frequency as determined by the delay time. In the voltage controlled oscillator thus arranged, the output frequency is determined by controlling a delay time of the second variable delay circuit in the voltage controlled oscillator section.