Abstract: The invention relates to new antimicrobially active 3-cephem compounds, processes for preparing such compounds, new intermediate compounds comprising alkoxyimino dioxy butyric acid derivatives useful in said processes, and processes for preparation of said intermediates.

Abstract: The present invention relates to novel benzhydrylpiperazine derivatives having anti-allergic activities, the preparation of these derivatives, pharmaceutical compositions comprising the same, and to a method of using these compounds therapeutically in the treatment of allergic symptoms in human beings and animals.These benzhydrylpiperazine derivatives have the follow formula: ##STR1## wherein A is a lower alkylene, Z is a benzhydryl optionally substituted with halogen, andR.sup.1 is amino, aryl, pyridyl, acyl or acylamino, in which the aryl group and pyridyl group are substituted with nitro, amino or acyl amino groups, provided that Z is benzhydryl substituted with a halogen, when R.sup.1 is an amino group.

Abstract: The invention relates to novel dihydropyridine derivatives of vasodilating activity of the formula: ##STR1## in which R.sup.1 is aryl selected from the group consisting of phenyl, tolyl, xylyl, cumenyl and mesityl which may have one or more substituents selected from the group consisting of halogen, nitro, hydroxy, carboxy and lower alkoxy, or a heterocyclic group containing at least one hetero atom selected from the group consisting of oxygen, nitrogen and sulfur,R.sup.2 is lower alkoxy-carbonyl or N,N-disubstituted amino(lower)alkoxycarbonyl,R.sup.3 is lower alkyl, alkanoyl, protected alkanoyl or cyano,R.sup.4 is lower alkyl andA is lower alkylene, and pharmaceutically acceptable salt thereof.

Abstract: New .alpha.-aryl-.alpha.-pyridylalkanoic acid derivatives of the formula: ##STR1## wherein R.sup.1 is cyano or carbamoyl,R.sup.2 is hydrogen or halogen,R.sup.3 is hydrogen or lower alkyl,one of R.sup.4 and R.sup.5 is hydrogen and another is lower alkyl,R.sup.6 is hydrogen or lower alkyl, andR.sup.7 is lower alkyl, orR.sup.6 and R.sup.7 are taken together to form an N-containing saturated heterocyclic group with the adjacent nitrogen atom, in which the heterocyclic group may be substituted with lower alkyl or optionally protected hydroxy(lower)alkyl,provided that R.sup.2 is halogen or R.sup.3 is lower alkyl, when R.sup.1 is cyano and R.sup.6 and R.sup.7 are each lower alkyl, and salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same.These derivatives and salts thereof are useful as antiulcer agents and spasmolytic agents.

Abstract: New fused imidazole compounds of the formula: ##STR1## wherein A is lower alkylene,R.sup.1 is hydrogen, lower alkyl, lower alkoxy or halogen,R.sup.2 is hydrogen, lower alkyl, cyclo(lower)alkyl, pyridyl, ar(lower)alkyl which may be substituted with halogen, or aryl which may be substituted with lower alkyl, lower alkoxy, hydroxy or halogen,R.sup.3 is N-containing unsaturated heterocyclic group which may be substituted with lower alkyl or amino, andY is .dbd.C-- or .dbd.N--,and pharmaceutically acceptable salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same.These derivatives and salts thereof are useful as antiulcer agents.

Abstract: New thiazine derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen or acyl,R.sup.2 is hydrogen or lower alkyl,R.sup.3 is hydrogen, hydroxy, halogen, lower alkyl or lower alkoxy,Z is taken together with the adjacent carbon atoms to form an unsaturated heterocyclic ring which may be substituted with phenyl, halogen, acyl or lower alkyl, andthe heavy solid line means single or double bond,and pharmaceutically acceptable salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same.These derivatives and salts thereof are useful as antiinflammatory, analgesic and antirheumatic agents.

Abstract: The invention relates to novel intermediates for preparing novel cephem compounds of high antimicrobial activity, the intermediates being of the formula: ##STR1## wherein A is lower alkylene which may have an oxo group;R.sup.3 is carboxy, protected carboxy, lower alkyl, lower alkenyl, hydroxy(lower)alkyl, phenyl(lower)alkyl or aryl; andR.sup.7a is hydrogen or a mercapto-protective group, or a salt thereof.

Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl, andR.sup.2 is hydrogen lower alkyl, carboxy(lower)alkyl, lower alkoxy(lower)alkyl, aliphatic acyl (lower)alkyl, aromatic acyl(lower)alkyl or heterocyclic acyl(lower)alkyl,and pharmaceutically acceptable salts thereof are useful for treatment of hypertension, heart disease and thrombosis.

Abstract: This invention is directed to new quinazoline derivatives of the following formula having use in the treatment of symptoms associated with allergic manifestations. ##STR1## wherein R.sub.a.sup.1 and R.sub.b.sup.1 are C.sub.2 -C.sub.7 alkoxycarbonyl or R.sub.a.sup.1 and R.sub.b.sup.1 is linked together to form a group of the formula: ##STR2## R.sup.2 and R.sup.3 are hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, nitro, amino, C.sub.1 -C.sub.6 alkoxy, phenoxy, C.sub.1 -C.sub.6 alkylthio, C.sub.1 -C.sub.6 alkylpiperazinyl, C.sub.1 -C.sub.18 alkanoylamino, di(C.sub.1 -C.sub.6)alkanoylamino, C.sub.3 -C.sub.9 alkoxalylamino, C.sub.4 -C.sub.8 cycloalkylcarbonylamino, C.sub.3 -C.sub.7 cycloalkyl(C.sub.1 -C.sub.6)alkanoylamino, benzamido, phenyl(C.sub.1 -C.sub.6)alkanoylamino, C.sub.1 -C.sub.6 alkylsulfonylamino or di(C.sub.1 -C.sub.6)alkylamino which may be substituted with hydroxy,A.sup.1 is a group of the formula: ##STR3## in which R.sup.4 is hydrogen C.sub.1 -C.sub.6 alkyl, hydroxy, C.sub.1 -C.sub.6 alkoxy, C.sub.

Abstract: This invention relates to pyridylalkyl nitrate compound and a salt thereof. More particularly, it relates to a new pyridylalkyl nitrate compound and a pharmaceutically acceptable salt thereof which have vasodilating activities, to process for the preparation thereof, and to a pharmaceutical composition comprising the same for therapeutical treatment of cardiovascular disorder in human being.

Abstract: The invention relates to novel tropone derivatives, of antiinflammatory, analgesic and antirheumatic activity, of the formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl,R.sup.2 is hydrogen, hydroxy, halogen, lower alkyl, or lower alkoxy, andR.sup.3 is hydrogen or acyl,and pharmaceutically acceptable salts thereof.

Abstract: The invention relates to new compounds comprising alkoxyimino dioxy butyric acid cephem derivatives of high antimicrobial activity.

Abstract: This invention relates to novel 7-acylaminocephalosporanic acid derivatives of high antimicrobial activity, to processes for their preparation, and to pharmaceutical compositions comprising said derivatives, said derivatives being of the formula: ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is dialkanoyloxy(lower)alkyl; alkyl having one or more substituents selected from the group consisting of hydroxy, protected hydroxy, alkoxy, carboxy, protected carboxy, cycloalkylcarbonyloxy and heterocyclic group; lower alkoxycarbonyloxy(lower)alkyl; azido(lower)alkoxycarbonyloxy(lower)alkyl; aroyloxy(lower)alkyl; higher alkanoyloxy(lower)alkyl; phthalidyl; or phthalidylidene(lower)alkyl,R.sup.3 is lower alkyl,Y is thio (--S--) or sulfinyl (--S--), and the dotted line represents 2- or 3-cephem nuclei.

Abstract: A magnetic coating composition used for producing magnetic recording media is disclosed. The composition is comprised of partially oxidized nitrocellulose and magnetic fine powder or magnetic metal fine powder. The composition may also include a synthetic resin binder. The partially oxidized nitrocellulose has a nitrogen content of 8.0 to 12.5% and contains 2.0 to 100 mmol of carboxyl group per 100 g of nitrocellulose. Use of the partically oxidized nitrocellulose gives increased ability to disperse the magnetic powder within the composition and does not adversely effect the adhesion between the composition and the support.

Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is phenyl substituted with halogen or lower alkyl, and R.sup.4 is a group of the formula C.sub.n H.sub.2n in which n is an integer of 1 to 7; or a pharmaceutically acceptable salt thereof. The compound exhibits antipyretic, analgesic and anti-inflammatory properties.

Abstract: A magnetic coating composition for use in the production of a magnetic recording material is described. The composition is comprised of at least ferromagnetic metal powder and/or ferromagnetic alloy powder and nitrocellulose having an average degree of polymerization of from 10 to 55, or at least ferromagnetic metal powder and/or ferromagnetic alloy powder, nitrocellulose having an average degree of polymerization of from 10 to 55, and at least one polymeric binder. This magnetic coating composition has excellent dispersibility of the magnetic powder, and can provide a magnetic recording material which has excellent surface smoothness and orientation ratio, as well as excellent durability.

Abstract: This invention relates to novel cephem compounds of high antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group;R.sup.2 is carboxy or a protected carboxy group;A is lower alkylene which may have an oxo group;R.sup.3 is carboxy, a protected carboxy group, lower alkyl, lower alkenyl, hydroxy (lower) alkyl, phenyl (lower) alkyl, phenyl, tolyl, xylyl, cumenyl, or naphthyl; andR.sup.4 is hydrogen or lower alkoxy, and pharmaceutically acceptable salts thereof.

Abstract: The invention is directed to compounds of the formula ##STR1## wherein R.sub.a.sup.1 is phenyl,R.sup.2 is halogen,R.sup.3 is carboxy or lower alkoxycarbonyl,Y.sub.a is oxygen,A is C.sub.1 -C.sub.6 alkylene,pharmaceutically acceptable salts thereof, and aldose reductase inhibiting pharmaceutical compositions thereof.

Abstract: Quinazoline derivatives of the formulae: ##STR1## wherein A.sup.1 is ##STR2## A.sup.2 is ##STR3## R.sup.1 is hydrogen, carboxy or esterified carboxy, R.sub.a.sup.1 and R.sub.b.sup.1 are esterified carboxy,R.sup.2 and R.sup.3 are hydrogen, alkyl, halogen, nitro, amino, alkoxy, aryloxy, alkylthio, alkylpiperazinyl, acylamino or dialkylamino which may be substituted with hydroxy,R.sup.4 is hydrogen, alkyl, hydroxy, alkoxy, alkenyloxy, dialkylamino or 2,2-dialkoxycarbonylvinylaminoR.sub.a.sup.4 is hydrogen, alkyl, hydroxy, alkoxy, alkenyloxy or dialkylamino,R.sup.5 is alkyl or alkenyl, andR.sup.6 is carboxy or esterified carboxy.

Abstract: Benzhydrylpiperazinyl Thiazole compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, amino, or mono- or di- substituted amino, in which the substituent is selected from lower alkyl, acyl and di(lower)alkylaminomethylene,R.sup.2 is hydrogen, halogen, lower alkyl or aryl,R.sup.3 is ar(lower)alkyl optionally substituted by halogen,A is lower alkylene optionally interrupted by a sulfur atom, andY is C.sub.1 -C.sub.3 alkylene,having antiallergic activity.