Abstract: An optical-waveguide sensor chip includes an optical waveguide having a first substance immobilized on the surface thereof, the first substance being specifically reactive with an analyte substance, and fine particles dispersed on the optical waveguide and having a second substance immobilized on the surface thereof, the second substance being specifically reactive with the analyte substance.

Abstract: According to one embodiment, a double-sided coating apparatus includes a transport mechanism configured to convey the substrate, a first coating head disposed on one surface side of the substrate and configured to apply the coating liquid to the coated and uncoated regions, a second coating head disposed on the other surface side of the substrate and configured to apply the coating liquid to the coated and uncoated regions, and a coating roll disposed on the one surface side of the substrate and near a position where the coating roll is opposed to the second coating head with the substrate therebetween and includes first rollers disposed on axially opposite portions, at least one second roller disposed between the first rollers, and a rotation mechanism configured to rotate the first and second rollers such that the peripheral speed of the first rollers is higher than that of the second roller.

Abstract: According to one embodiment, a double-sided coating apparatus includes a first coating head arranged on one side of a raw material to coat the one side with a coating liquid by alternately forming a coating region and a non-coating region in a direction crossing a delivery direction, a second coating head arranged on the other side of the raw material to coat the other side with the coating liquid by alternately forming the coating region and the non-coating region in the direction crossing the delivery direction, and a coating roller arranged near a position on the one side of the raw material and opposite to the second coating head across the raw material and having a large-diameter portion and a small-diameter portion with different diameters along an axial direction with the small-diameter portion opposite to the coating region and the large-diameter portion opposite to the non-coating region.

Abstract: According to one embodiment, an optical sensor includes an optical waveguide module and a specimen area. The specimen area is provided adjacent to the optical waveguide module, and is configured to hold a specimen. The specimen area includes a sensing area and a precipitation area. An optical change occurs in the sensing area. A precipitate of the specimen is precipitated in the precipitation area. The precipitation area is placed at a different position from a position of the sensing area which is attached to the optical waveguide module.

Abstract: A fluorometric apparatus capable of configuring to have a small size and operability requiring a simple and easy operation of centrifuging a specimen in a container a rotation center of which is detachably supported by a rotation axis (not shown), exciting the specimen by means of an N2 laser apparatus and an excitation light irradiator for guiding the laser light emitted from the N2 laser apparatus, and receiving fluorescence having two types of wavelengths emitted from antibodies labeled with fluorescent dyes in the specimen in a region separate from the region in which the excitation light is radiated by a predetermined angle by using a photomultiplier tube, obtaining a ratio of light intensity for each wavelength, comparing the obtained ratio with a standard value, and estimating a target protein concentration.

Abstract: According to one embodiment, a glucose sensor chip includes an optical waveguide layer on a main surface of a substrate, the optical waveguide layer including a pair of gratings which are separated each other, a sensing film on a surface of a portion of the optical waveguide layer between the pair of the gratings, the sensing film being constituted with a membrane polymer, a cross-linking polymer and a low-molecular compound, the sensing film including a first enzyme which oxidizes or reduces a color forming dye and a glucose, and a second enzyme which reacts with a product of the first enzyme and generates a material which produces the color forming dye.

Abstract: This method of analyzing a biological component includes steps of arranging an extraction medium holding part configured to be capable of holding a prescribed quantity of extraction medium for holding an extract extracted from a subject on the skin of the subject, transferring the extraction medium stored in a liquid storing part storing substantially the same quantity of the extraction medium as the prescribed quantity to the extraction medium holding part, transferring at least part of the extraction medium holding the extracted extract to a reaction part, and analyzing a result of detecting the extract.

Abstract: An optical sensor (1) includes a sensor chip member (2) having an optical waveguide layer (21), a combination of an incidence end grating (22a) and an output end grating (22b) spaced from each other, in contact with the optical waveguide layer (21), and a reaction reagent (23) provided on the optical waveguide layer (21) to detect as an optical change a quantity of measurement object interposed between the incidence end grating (22a) and the output end grating (22b), and a chamber member (3) to have, when the sensor chip member (2) is assembled, a facing surface (F) in position facing the optical waveguide layer (21), and a gap (I) defined between the optical waveguide layer (21) and the facing surface (F), the reaction reagent (23) being disposed in the gap (I).

Abstract: An optical waveguide type antibody chip includes a transparent substrate, an incident-side optical element and an emitting-side optical element placed at a distance from each other on a primary face of the substrate, a water repellent resin film formed on the primary face of the substrate including an optical waveguide layer formed between the optical elements, the water repellent resin film includes a reaction hole having exposed the optical waveguide layer on its bottom and a frame-shaped trench surrounding the reaction hole, a rectangular frame-shaped cell wall which is fixed in the trench of the water repellent resin film and which forms a cell capable of infusion and discharge of a specimen solution together with the reaction hole, and an antibody immobilization layer formed on the bottom of the reaction hole, the surface of the antibody immobilization layer being masked with at least a buffer agent and a salt.

Abstract: An optical glucose sensor chip includes a substrate, a pair of optical elements formed on a surface of the substrate for introducing light into the substrate and for emitting the light from the substrate, and a glucose sensing membrane formed on the surface of the substrate at a position between the optical elements. The sensing membrane includes a color reagent substrate, a first enzyme which oxidizes or reduces glucose, a second enzyme that generates a material which makes the color reagent substrate exhibit color by a reaction with a product obtained by oxidation or reduction of glucose, a nonionic cellulose derivative, and an ionic polymer into which a buffer is incorporated. At least one of the first and second enzymes is coated with the ionic polymer, and the color reagent substrate. The first and second enzymes, the buffer and the ionic polymer are supported by the nonionic cellulose derivative.

Abstract: A measuring apparatus uses a biological component sensor including a plate-shaped sensor chip having a biological component sensing function and a sensor chip holding frame surrounding and holding the sensor chip. The biological component sensor is disposed in a measuring apparatus main body housing. A fixed engaging member and movable engaging member disposed on a sensor chip support table fixed to the measuring apparatus main body housing fix and support the sensor chip holding frame, and the sensor chip can be thus replaced. The biological component sensor contacts a forearm portion of a human body, and a biological component exuded from a contact part of the forearm portion is caused to contact the sensor chip to change a physical or chemical surface property of the sensor chip, thereby measuring the change through an irradiation of an inspection light to calculate concentration of the biological component.

Abstract: An optical biosensor has a total reflection plate so as to totally internally reflect and transmit an incident light, a first grating and a second grating disposed separately on the total reflection plate, and a sensing membrane that is containing an enzyme and a chromogenic reagent and is sandwiched by the first and second gratings on the total reflection plate.

Abstract: A method of preparing a coating solution for a glucose sensing membrane, the method comprising preserving a first solution containing an oxidizing enzyme or a reducing enzyme of glucose and a reagent for generating a substance for coloring a coloring agent dissolved in a buffer solution, preserving a second solution containing a mixed solution of an alcohol solution of the coloring agent and a solution of a membrane-forming polymer compound, and mixing the first solution and the second solution.

Abstract: An optical-waveguide sensor chip includes an optical waveguide having a first substance immobilized on the surface thereof, the first substance being specifically reactive with an analyte substance, and fine particles dispersed on the optical waveguide and having a second substance immobilized on the surface thereof, the second substance being specifically reactive with the analyte substance.

Abstract: An optical sensor (1) includes a sensor chip member (2) having an optical waveguide layer (21), a combination of an incidence end grating (22a) and an output end grating (22b) spaced from each other, in contact with the optical waveguide layer (21), and a reaction reagent (23) provided on the optical waveguide layer (21) to detect as an optical change a quantity of measurement object interposed between the incidence end grating (22a) and the output end grating (22b), and a chamber member (3) to have, when the sensor chip member (2) is assembled, a facing surface (F) in position facing the optical waveguide layer (21), and a gap (I) defined between the optical waveguide layer (21) and the facing surface (F), the reaction reagent (23) being disposed in the gap (I).

Abstract: A method for measuring samples includes fitting and mounting, onto a transfer stage, a chip pallet for transporting sensor chips; fitting a positioning hole of a chip package onto a positioning pin; pulling a bottom plate of the chip package off the chip package, so as to simultaneously transfer the housed sensor chips onto the transfer stage; pulling upward the chip pallet so as to simultaneously transfer, onto the chip pallet, the sensor chips on the transfer stage; and mounting the chip pallet having the sensor chips mounted thereon onto a measuring device, and measuring samples.

Abstract: The method for measuring the concentration of the measuring object uses a sensor chip comprising an optical waveguide layer and an antibody immobilized layer formed on the surface of the optical waveguide layer, which comprises immobilizing the measuring object and an enzyme-labeled antibody labeled with a labeling enzyme on the antibody immobilized layer of the sensor chip having an immobilized antibody, producing a color-developing and precipitating enzyme reaction product by allowing to react a coloring reagent with the labeling enzyme on the antibody immobilized layer to precipitate the enzyme reaction product on the antibody immobilized layer, allowing to totally reflect a light impinged on the sensor chip from the outside at an interface between the optical waveguide layer and the antibody immobilized layer, and observing to a physical value of the totally reflected light.

Abstract: An optical waveguide type antibody chip includes a transparent substrate, an incident-side optical element and an emitting-side optical element placed at a distance from each other on a primary face of the substrate, a water repellent resin film formed on the primary face of the substrate including an optical waveguide layer formed between the optical elements, the water repellent resin film includes a reaction hole having exposed the optical waveguide layer on its bottom and a frame-shaped trench surrounding the reaction hole, a rectangular frame-shaped cell wall which is fixed in the trench of the water repellent resin film and which forms a cell capable of infusion and discharge of a specimen solution together with the reaction hole, and an antibody immobilization layer formed on the bottom of the reaction hole, the surface of the antibody immobilization layer being masked with at least a buffer agent and a salt.

Abstract: An optical waveguide type iontophoresis sensor chip has a substrate having a first hinged plate and a second hinged plate, an optical waveguide plate connected to the first hinged plate and positioned over a first opening delineated in the first hinged plate, and a gel layer fixed on the second hinged plate and covering a second opening delineated in the second hinged plate and configured to contact with the optical waveguide plate through the first opening in case that the substrate is folded.

Abstract: A color reaction detecting device includes: a support configured to support a sensor chip, the sensor chip including a thin film which causes a color reaction by a substance released from an object under inspection; a light source configured to introduce light into the sensor chip supported by the support; a photodetector configured to sense light emitted from the sensor chip; a temperature sensor configured to measure temperature; and a control unit. The control unit computes an amount of color reaction in the sensor chip using a result of the sensing by the photodetector and a result of the measurement by the temperature sensor.