Patents by Inventor Ikuo Yamashina

Ikuo Yamashina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Low-molecular heparin modification and remedy for skin ulcer
    Patent number: 6569840
    Abstract: The invention is direct to modified heparins, especially low-molecular weight modified heparins that are adapted for used in preparing an agent for treating a skin ulcer. The low-molecular weight modified heparins have been substantially deprived of the anticoagulant activity, yet they retain the ability to bind to cell growth factors, cytokines and cell adhesion molecules.
    Type: Grant
    Filed: May 9, 2000
    Date of Patent: May 27, 2003
    Inventors: Ikuo Yamashina, Minoru Okayama, Ken-ichi Toda
  • Hybridoma and monoclonal antibody MLS102 which recognizes a NeuAc.alpha.2.fwdarw.6GalNAc sugar chain present on human intestinal cancer cells
    Patent number: 5194385
    Abstract: The present invention relates to a monoclonal antibody MLS 102 recognizing human intestinal cancer cells, especially their sugar chain of glycoprotein, and more specifically NeuAc .alpha.2.fwdarw.6GalNAc. The invention also relates to a hybridoma producing the monoclonal antibody which is prepared by fusing splenic cells of a mouse immunized by human intestinal cancer cells with myeloma cells.
    Type: Grant
    Filed: November 13, 1990
    Date of Patent: March 16, 1993
    Assignee: Shionogi & Co., Ltd.
    Inventor: Ikuo Yamashina
  • Monoclonal antibody NKY13
    Patent number: 5073493
    Abstract: Monoclonal antibody NKY13 recognizing sugar chains of mucin-type glycoproteins secreted by cancer cells, for example, the following sugar chains, and hydridoma producing it: ##STR1## The monoclonal antibody NKY13 renders it possible to make highly sensitive judgements in the serodiagnosis of such cancers as colon cancer, stomach cancer and pancreas cancer.
    Type: Grant
    Filed: May 26, 1988
    Date of Patent: December 17, 1991
    Assignee: Ikuo Yamashina
    Inventor: Ikuo Yamashina
  • Plates for assay of sugar chaindirected antibody and production thereof
    Patent number: 4851357
    Abstract: The invention relates to an assay plate for a sugar chain-directed antibody on which a mucin-type glycopeptide is fixed in a solid phase in the presence of an alkylenedialdehyde and a basic poly-peptide or basic synthetic polymer. The invention also relates to an assay plate wherein a serum-type glycopeptide is fixed in a solid phase by acylation with a higher fatty acid, which makes an assay fo sugar chain-directed antibody possible. Moreover, the invention makes the preparation of a hybridoma producing sugar chain-directed antibody possible, and relates to a process for the production thereof.
    Type: Grant
    Filed: March 12, 1987
    Date of Patent: July 25, 1989
    Inventor: Ikuo Yamashina
  • Plasminogen-activating substance and the preparation and use of such substance
    Patent number: 4265881
    Abstract: A new type of plasminogen-activating substance is extracted from the bile of hogs, which substance is characterized by;(A) a molecular weight of 80,000 .+-.10,000;(B) an isoelectric point of 7.1;(C) an ultraviolet absorption spectrum showing a peak (.lambda. max) at a wave length of about 278 nm;(D) a fibrinolysis activity such that a Ca-added standard fibrin plate is lysed but a heated fibrin plate is not lysed;(E) such a high thermal stability that heating at a temperature of 80.degree. C. for 10 minutes causes the plasminogen-activating activity to be decreased to an extent corresponding to 50% of the original activity and heating at a temperature of 60.degree. C.
    Type: Grant
    Filed: March 17, 1980
    Date of Patent: May 5, 1981
    Assignee: Tobishi Pharmaceutical Co., Ltd.
    Inventors: Ikuo Yamashina, Toshisuke Kawasaki, Michiko Tsukuda