Abstract: Dioxacycloalkane compounds of the formula ?1! ##STR1## wherein A is ##STR2## wherein W is ##STR3## X is --CO-- or --SO.sub.2 --; Y is --CH.sub.2 --, --O-- or --NR.sup.25 --; and R.sup.1 is an aralkyl which may be substituted by lower alkoxy;R.sup.2 is a hydrogen atom or a lower alkyl;R.sup.3 is --(CH.sub.2)d-SR.sup.26 or ##STR4## R.sup.4 and R.sup.5 are each a hydrogen atom or a lower alkyl; and E is --C(R.sup.29)(R.sup.30)-- or --CH.sub.2 CH.sub.2 --, pharmaceutically acceptable salts thereof, intermediates for producing said compounds, and methods for producing said intermediates. The compounds of the formula ?1! have a strong inhibitory activity against renin and show continuous hypotensive action by oral administration. They are useful as hypotensive agents or therapeutic agents for heart failure.

Abstract: A protection device for an electric appliance comprising a differential transformer comprising a magnetic core disposed around a pair of wires leading to the appliance from the source and a sensing wire thereon; a solenoid driven switch for cutting off the source in response to a leakage current in the wires; an SCR which is normally non-conducting for connecting the solenoid to the source in the conducting state so as to cause the switch to be in a cut-off state; a voltage regulator for supplying suitable regulated voltage to an amplifier and a latched-trigger circuit; an amplifier connected to the sensing wires for providing a signal to the latched-trigger circuit; and a latched-trigger circuit for taking the signal from the amplifier and in response thereto provide a trigger signal to cause the SCR to be in a conducting state so as to operate the solenoid and cut-off switch.

Abstract: A human-mouse hybridoma producing a human monoclonal antibody specific for human lung squamous and adenocarcinomas. The human monoclonal antibody can be utilized as a diagnostic agent in serological diagnosis, in the radioimmaging of lung tumors or as a therapeutic agent.