Abstract: The present disclosure relates to an active substance carrier comprising a core-shell network structure formed using a biopolymer. In an aspect of the present disclosure, the core-shell network structure comprises a core-shell particle comprising: a core comprising prolamin; and a shell comprising pullulan and pectin, wherein the pullulan comprised in the shell surrounds the core and the pectin is located in the outermost layer of the shell, so that a network is formed between the core-shell particles. It can effectively facilitate the transdermal absorption of an active substance.

Abstract: A cosmetic composition includes a compound of the following chemical formula as an active ingredient. A method for regenerating skin includes applying an effective amount of the cosmetic composition to skin: wherein R1 to R7 are independently a substituted or unsubstituted C1 to C20 alkyl group.

Abstract: A cosmetic composition includes a compound of the following chemical formula as an active ingredient. A method for regenerating skin includes applying an effective amount of the cosmetic composition to skin: wherein R1 to R7 are independently a substituted or unsubstituted C1 to C20 alkyl group.

Abstract: The present disclosure relates to an active substance carrier comprising a core-shell network structure formed using a biopolymer. In an aspect of the present disclosure, the core-shell network structure comprises a core-shell particle comprising: a core comprising prolamin; and a shell comprising pullulan and pectin, wherein the pullulan comprised in the shell surrounds the core and the pectin is located in the outermost layer of the shell, so that a network is formed between the core-shell particles. It can effectively facilitate the transdermal absorption of an active substance.

Abstract: According to an embodiment, a method of producing artificial skin includes mixing fibroblasts and collagen to form a dermis simulating layer, applying keratinocytes on the dermis simulating layer and culturing the same, culturing the dermis simulating layer in a first medium that is a keratinocyte medium, and culturing the dermis simulating layer that is cultured in the first medium in a second medium including a DMEM medium and a F12 medium.

Abstract: The present disclosure relates to a drug delivery carrier containing a lipid structure or a polymer particle which is covalently bonded to a cell-penetrating AP-GRR peptide (SEQ ID NO 1) or is modified with the peptide chain containing the peptide. The present disclosure also relates to a composition containing the drug delivery carrier and a physiologically active ingredient encapsulated in the carrier. The drug delivery carrier of the present disclosure can effectively deliver macromolecules that are difficult to be delivered into cells, thereby improving the bioavailability of the macromolecules.

Abstract: The present invention provides a composition for accelerating a change in muscle type, increasing the amount of muscle, strengthening muscle, enhancing athletic abilities, reducing lipids, suppressing the accumulation of lipids, lowering blood sugar, controlling body weight or lowering body weight, containing a PPAR-? promoter, an AMPK promoter and a PGC1-? promoter as an active ingredient.

Abstract: Disclosed is a novel compound acting as a cannabinoid receptor 1 inhibitor, the compound being a pyrazolo[1,5-a]pyrimidine derivative, a prodrug thereof, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof. The novel compound or the like is useful for preventing or treating diseases mediated by the cannabinoid receptor-1.

Abstract: The present invention provides a composition for accelerating a change in muscle type, increasing the amount of muscle, strengthening muscle, enhancing athletic abilities, reducing lipids, suppressing the accumulation of lipids, lowering blood sugar, controlling body weight or lowering body weight, containing a PPAR-? promoter, an AMPK promoter and a PGC1-? promoter as an active ingredient.

Abstract: Disclosed is a novel compound acting as a cannabinoid receptor 1 inhibitor, a prodrug thereof, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof. The novel compound or the like is useful for preventing or treating diseases mediated by the cannabinoid receptor-1.

Abstract: The present invention provides a composition for accelerating a change in muscle type, increasing the amount of muscle, strengthening muscle, enhancing athletic abilities, reducing lipids, suppressing the accumulation of lipids, lowering blood sugar, controlling body weight or lowering body weight, containing a PPAR-? promoter, an AMPK promoter and a PGC1-? promoter as an active ingredient