Patents by Inventor IL MINN

IL MINN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11124845
    Abstract: The presently disclosed subject matter provides methods, reporter gene constructs, and kits for using prostate-specific membrane antigen (PSMA) as an imaging reporter to image a variety of cells and tissues.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: September 21, 2021
    Assignee: The Johns Hopkins university
    Inventors: Martin G. Pomper, Mark Castanares, Il Minn, Shawn Lupold
  • Patent number: 10857246
    Abstract: Highly potent and selective radionuclide-based imaging and therapy agents targeting carbonic anhydrase IX with minimum non-specific organ uptake are disclosed. Methods of imaging and/or treating carbonic anhydrase IX-expressing cells or tumors also are disclosed.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: December 8, 2020
    Assignee: The Johns Hopkins University
    Inventors: Xing Yang, Il Minn, Steven Rowe, Sangeeta Ray, Ronnie C. Mease, Michael Gorin, Mohamad Allaf, Martin G. Pomper
  • Publication number: 20200347464
    Abstract: Methods, reporter gene constructs, and kits for using prostate-specific membrane antigen (PSMA) as an imaging reporter to image a variety of cells and tissues are provided.
    Type: Application
    Filed: July 21, 2020
    Publication date: November 5, 2020
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Mark Castanares, Il Minn, Shawn Lupold
  • Publication number: 20200297693
    Abstract: Provided are compounds generated by conjugation of triptolide with glucose to form glucose-triptolide conjugates, provides compounds with effective anti-proliferative activity and improved tolerability as compared to naturally occurring triptolide compounds.
    Type: Application
    Filed: June 11, 2020
    Publication date: September 24, 2020
    Inventors: JUN LIU, QINGLI HE, MARTIN G. POMPER, IL MINN, BIAO YU, QIAOLING WANG
  • Patent number: 10695319
    Abstract: Provided are compounds generated by conjugation of triptolide with glucose to form glucose-triptolide conjugates, provides compounds with effective anti-proliferative activity and improved tolerability as compared to naturally occurring triptolide compounds.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: June 30, 2020
    Assignees: The Johns Hopkins University, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
    Inventors: Jun Liu, Qingli He, Martin G. Pomper, Il Minn, Biao Yu, Qiaoling Wang
  • Publication number: 20200140831
    Abstract: A DNA plasmid useful for diagnostic and therapeutic gene therapy is disclosed. Improvements to gene therapy methods known in the art are provided to ensure cancer-targeting, high efficacy, and long durability of expression. The DNA plasmid is combined with compositions of polymeric nanoparticles for non-viral gene therapy to treat cancer, including hepatocellular carcinoma and prostate cancer.
    Type: Application
    Filed: October 1, 2019
    Publication date: May 7, 2020
    Inventors: Jordan J. Green, Martin G. Pomper, Camila Gadens Zamboni, Hannah Vaughan, Il Minn
  • Publication number: 20190192699
    Abstract: Highly potent and selective radionuclide-based imaging and therapy agents targeting carbonic anhydrase IX with minimum non-specific organ uptake are disclosed. Methods of imaging and/or treating carbonic anhydrase IX-expressing cells or tumors also are disclosed.
    Type: Application
    Filed: May 12, 2017
    Publication date: June 27, 2019
    Inventors: Xing YANG, Il MINN, Steven ROWE, Sangeeta RAY, Ronnie C. MEASE, Michael GORIN, Mohamad ALLAF, Martin G. POMPER
  • Patent number: 10156521
    Abstract: A detectable substrate for aldehyde dehydrogenase (ALDH) can be used for selecting cells that express ALDH. The detectable substrate can have a fluorescent moiety that has an excitation wavelength, an emission wavelength, or both, that does not overlap with the excitation wavelength, emission wavelength, or both, of green fluorescent protein.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: December 18, 2018
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Haofan Wang, Il Minn, Steven D. Leach, Ronnie C. Mease
  • Publication number: 20180177892
    Abstract: Compositions comprising a polymeric micellar nanoparticle composition comprising a block or graft copolymer comprising at least one polycationic polymer and at least one polyethylene glycol (PEG) polymer having an average molecular weight less than 1 kDa, and at least one nucleic acid, wherein the graft or block copolymer and at least one nucleic acid are complexed and condensed into a shaped micellar nanoparticle that is stable in biological media are disclosed. The presently disclosed subject matter also provides a method for preparing the presently disclosed polymeric micellar nanoparticle compositions, a method for targeting at least one metastatic cancer cell in a subject, and a method for treating a disease or condition using the presently disclosed polymeric micellar nanoparticle compositions.
    Type: Application
    Filed: February 7, 2018
    Publication date: June 28, 2018
    Inventors: HAI-QUAN MAO, JOHN MICHAEL WILLIFORD, MAANI ARCHANG, IL MINN, YONG REN, JOSE LUIS SANTOS, MARTIN G. POMPER
  • Publication number: 20180133348
    Abstract: Highly potent and selective radionuclide-based imaging and therapy agents targeting carbonic anhydrase IX with minimum non-specific organ uptake are disclosed. Methods of imaging and/or treating carbonic anhydrase IX-expressing cells or tumors also are disclosed.
    Type: Application
    Filed: June 1, 2016
    Publication date: May 17, 2018
    Inventors: XING YANG, IL MINN, STEVEN ROWE, SANGEETA RAY, RONNIE C. MEASE, MICHAEL GORIN, MOHAMAD ALLAF, MARTIN G. POMPER
  • Publication number: 20170218464
    Abstract: The presently disclosed subject matter provides methods, reporter gene constructs, and kits for using prostate-specific membrane antigen (PSMA) as an imaging reporter to image a variety of cells and tissues.
    Type: Application
    Filed: March 18, 2015
    Publication date: August 3, 2017
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: MARTIN G. POMPER, MARK CASTANARES, IL MINN, SHAWN LUPOLD
  • Publication number: 20160331845
    Abstract: Compositions comprising a polymeric micellar nanoparticle composition comprising a block or graft copolymer comprising at least one polycationic polymer and at least one polyethylene glycol (PEG) polymer having an average molecular weight less than 1 kDa, and at least one nucleic acid, wherein the graft or block copolymer and at least one nucleic acid are complexed and condensed into a shaped micellar nanoparticle that is stable in biological media are disclosed. The presently disclosed subject matter also provides a method for preparing the presently disclosed polymeric micellar nanoparticle compositions, a method for targeting at least one metastatic cancer cell in a subject, and a method for treating a disease or condition using the presently disclosed polymeric micellar nanoparticle compositions.
    Type: Application
    Filed: May 13, 2016
    Publication date: November 17, 2016
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: HAI-QUAN MAO, JOHN MICHAEL WILLIFORD, MAANI ARCHANG, IL MINN, YONG REN, JOSE LUIS SANTOS, MARTIN G. POMPER
  • Publication number: 20160008493
    Abstract: A detectable substrate for aldehyde dehydrogenase (ALDH) can include a radiolabel. When acted upon by ALDH in an ALDH-expressing cell, e.g., cancer cells, the radiolabeled substrate accumulates in the ALDH-expressing cell. ALDH-expressing cells can be distinguished by the accumulated radioactivity. When combined with suitable imaging technique, the detectable substrate can be used for in vivo imaging of cancer cells.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 14, 2016
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: MARTIN C. POMPER, HAOFAN WANG, IL MINN, RONNIE C. MEASE
  • Publication number: 20150369738
    Abstract: A detectable substrate for aldehyde dehydrogenase (ALDH) can be used for selecting cells that express ALDH. The detectable substrate can have a fluorescent moiety that has an excitation wavelength, an emission wavelength, or both, that does not overlap with the excitation wavelength, emission wavelength, or both, of green fluorescent protein.
    Type: Application
    Filed: February 21, 2014
    Publication date: December 24, 2015
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: MARTIN G. POMPER, HAOFAN WANG, IL MINN, STEVEN D. LEACH, RONNIE C. MEASE