Abstract: A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.

Abstract: Systems and methods are disclosed for increasing a nuclear spin polarization of a target compound. In accordance with such systems and methods, a first non-thermal equilibrium nuclear spin polarization can be imparted to at least one source atom of a source compound, the source atom having a nuclear gyromagnetic ratio of at least 12 megahertz per tesla (MHz/T). A first solution can be obtained that includes the source compound and a target compound. The at least one source atom can be present in a source concentration of at least 0.1 molar (M) in the first solution. A second non-thermal equilibrium nuclear spin polarization of at least 0.01% can be imparted to the at least one target atom of the target compound via a nuclear Overhauser effect (NOE) transfer of the first non-thermal equilibrium nuclear spin polarization to the at least one target atom.

Abstract: The present disclosure describes hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes methods for producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes precursor compounds for use in producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications.

Abstract: The present disclosure describes non-classical (e.g., quantum) computing systems and methods that utilize dopant molecules contained in host materials as qubits.

Abstract: Systems and methods are disclosed for generation of hyperpolarized target compounds. Generation of a hyperpolarized target compound can include application of a sequence of microwave pulses to a solution containing the target compound or a precursor of the target compound; or modulation of a magnetic field applied to the solution. When the precursor is hyperpolarized, the precursor can be cleaved to generate the hyperpolarized target compound. The hyperpolarized target compound can then be induced to precipitate out of the solution. The precipitate can be redissolved in a specified volume of solvent to form a solution having a desired concentration of the hyperpolarized target compound.

Abstract: The present disclosure describes non-classical (e.g., quantum) computing systems and methods that utilize dopant molecules contained in host materials as qubits.

Abstract: A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.

Abstract: The present disclosure describes non-classical (e.g., quantum) computing systems and methods that utilize dopant molecules contained in host materials as qubits.

Abstract: Systems and methods for generating hyperpolarized target materials are disclosed. The disclosed systems and methods can include hyperpolarizing a compound then transferring polarization to a target material. The compound can be selected to have nuclear spins. The compound can be further selected to have electron spins that, when exposed to certain electromagnetic radiation, exceed a predetermined level of polarization. The compound can be exposed to such electromagnetic radiation, optically hyperpolarizing the electron spins of the compound. Polarization can then be transferred from the electron spins of the compound to nuclear spins of the compound, at least in part by exposing the compound to a magnetic field. The compound can be exposed to the target material before or after pulverizing the compound to increase the surface area of the compound, thereby facilitating transfer of polarization from the compound to the target material.

Abstract: A method for generating a nuclear magnetic resonance spectrum of nuclear spin moments of a sample includes a static magnetic field permeating the sample, and a detection spin moment with a detection region surrounding the latter. The detection region extends at least partly into the sample.

Abstract: The invention relates to a method for the hyperpolarization of a material sample (4), which hits a number of first spin moments (10) of a first spin moment type, wherein the number of first spin moments (10) is brought into interaction with a second spin moment (16) of a second spin moment type, wherein the first spin moments (10) are nuclear spin moments and the second spin moment (16) is an election spin moment, wherein the first and second spin moments (10, 16) are exposed to a homogeneous magnetic field (B), wherein the second spin moment (16) is polarized along the magnetic field (B), wherein the second spin moment (16) is coherently manipulated by means of a, preferably repeated, sequence (S) having a number of successive high-frequency pulses (Pki, Pk?i) temporally offset to each by durations (Tki, Tk?i, T), in such a way that a polarization transfer from the second spin moment (16) to the first spin moments (10) occurs, and wherein durations (Tki, Tk?i, T) inversely proportional to a Lamor frequency (

Abstract: The invention relates to a method for generating a nuclear magnetic resonance spectrum (4) of nuclear spin moments (6) of a sample (8), comprising a static magnetic field (B) permeating the sample (8), and a detection spin moment (16) with a detection region (18) surrounding the latter, said detection region extending at least partly into the sample (8), and also an antenna element (22) for radiating in frequency pulses (F) for influencing the nuclear spin moments (6) and radio-frequency pulses (H) for influencing the detection spin moment (16), wherein a polarization step (42) involves polarizing at least one portion of the nuclear spin moments (6) along the magnetic field (B) to form a longitudinal magnetization (Mz), wherein a transfer step (44) involves converting the longitudinal magnetization (Mz) into a transverse magnetization (Mxy) by radiating in a frequency pulse (F) with a 90° flip angle, wherein a detection step (46) involves radiating in a sequence (S) of radio-frequency pulses (H) onto the dete

Abstract: A method of hyperpolarisation of nuclear spins in one or more particle(s) moving relatively to a polarisation structure, wherein a polarisation of electron spins in the polarisation structure is transferred to the nuclear spins in the particle(s), wherein for one or more of the moving particle(s) within 20 nm from a surface of the polarisation structure, the correlation time of the interaction with the nearest polarisation structure electron spin due to the molecular motion is larger than the inverse of the nuclear Larmor frequency; the electron spins in the polarisation structure are polarised above thermal equilibrium; and the polarisation transfer is performed resonantly.

Abstract: Embodiments of the present disclosure include a hyperpolarizing system, comprising a hyperpolarization reaction chamber having a location therein for supporting a solid catalyst with a sample in contact therewith, a cooler configured to lower a temperature of the sample and the solid catalyst to a temperature in a range of about 70K and about 250K, and an optical light source configured to direct light energy toward the solid catalyst to thereby hyperpolarize electrons in the solid catalyst and facilitate transfer of hyperpolarization to nuclei of the sample.

Abstract: The invention relates to a method for the hyperpolarization of a material sample (4), which hits a number of first spin moments (10) of a first spin moment type, wherein the number of first spin moments (10) is brought into interaction with a second spin moment (16) of a second spin moment type, wherein the first spin moments (10) are nuclear spin moments and the second spin moment (16) is an election spin moment, wherein the first and second spin moments (10, 16) are exposed to a homogeneous magnetic field (B), wherein the second spin moment (16) is polarized along the magnetic field (B), wherein the second spin moment (16) is coherently manipulated by means of a, preferably repeated, sequence (S) having a number of successive high-frequency pulses (Pki, Pk?i) temporally offset to each by durations (Tki, Tk?i, T), in such a way that a polarization transfer from the second spin moment (16) to the first spin moments (10) occurs, and wherein durations (Tki, Tk?i, T) inversely proportional to a Lamor frequency (

Abstract: A method of hyperpolarisation of nuclear spins in one or more particle(s) moving relatively to a polarisation structure, wherein a polarisation of electron spins in the polarisation structure is transferred to the nuclear spins in the particle(s), wherein for one or more of the moving particle(s) within 20 nm from a surface of the polarisation structure, the correlation time of the interaction with the nearest polarisation structure electron spin due to the molecular motion is larger than the inverse of the nuclear Larmor frequency; the electron spins in the polarisation structure are polarised above thermal equilibrium; and the polarisation transfer is performed resonantly.