Patents by Inventor Ilan K. Reich
Ilan K. Reich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230191012Abstract: A crossflow filter includes a rigid cylindrical inner wall and a rigid cylindrical outer wall inner with an inelastic filter membrane positioned therebetween defining a retentate channel inside the filter membrane and a permeate channel outside the filter membrane. Further, the filter includes transition channels shaped and connected to the inner and outer walls to deliver a flow of fluid from an inlet port to the retentate channel and to capture flow flowing longitudinally along the cylindrical inner and outer walls from both the retentate and permeate channels to respective outlet ports.Type: ApplicationFiled: February 13, 2023Publication date: June 22, 2023Applicant: Onco Filtration, Inc.Inventors: Stephen S. KEANEY, Katherine J. SOOJIAN, Russell W. BOWDEN, Ilan K. REICH
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Patent number: 11607480Abstract: A crossflow filter includes a rigid cylindrical inner wall and a rigid cylindrical outer wall with an inelastic filter membrane positioned therebetween defining a retentate channel inside the filter membrane and a permeate channel outside the filter membrane. Further, the filter includes transition channels shaped and connected to the inner and outer walls to deliver a flow of fluid from an inlet port to the retentate channel and to capture flow flowing longitudinally along the cylindrical inner and outer walls from both the retentate and permeate channels to respective outlet ports.Type: GrantFiled: May 8, 2020Date of Patent: March 21, 2023Assignee: ONCO FILTRATION, INC.Inventors: Stephen S. Keaney, Katherine J. Soojian, Russell W. Bowden, Ilan K. Reich
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Publication number: 20200268960Abstract: A crossflow filter includes a rigid cylindrical inner wall and a rigid cylindrical outer wall inner with an inelastic filter membrane positioned therebetween defining a retentate channel inside the filter membrane and a permeate channel outside the filter membrane. Further, the filter includes transition channels shaped and connected to the inner and outer walls to deliver a flow of fluid from an inlet port to the retentate channel and to capture flow flowing longitudinally along the cylindrical inner and outer walls from both the retentate and permeate channels to respective outlet ports.Type: ApplicationFiled: May 8, 2020Publication date: August 27, 2020Applicant: Viatar LLCInventors: Stephen S. KEANEY, Katherine J. SOOJIAN, Russell W. BOWDEN, Ilan K. REICH
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Patent number: 10702647Abstract: Filtering systems, methods, and devices, particularly adapted for apheresis of cellular bodies and more specifically for apheresis of circulating tumor cell bodies (CTCs) employs a cross-flow channel. Systems and methods as well as devices for such a system are described. Embodiments include a cylindrical filter that employs a thin micro-machined porous filter membrane with a regular array of pores and reliably pass blood while trapping CTCs.Type: GrantFiled: March 10, 2016Date of Patent: July 7, 2020Assignee: Viatar LLCInventors: Stephen S. Keaney, Katherine J. Soojian, Russell W. Bowden, Ilan K. Reich
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Publication number: 20180043084Abstract: Filtering systems, methods, and devices, particularly adapted for apheresis of cellular bodies and more specifically for apheresis of circulating tumor cell bodies (CTCs) employs a cross-flow channel. Systems and methods as well as devices for such a system are described. Embodiments include a cylindrical filter that employs a thin micro-machined porous filter membrane with a regular array of pores and reliably pass blood while trapping CTCs.Type: ApplicationFiled: March 10, 2016Publication date: February 15, 2018Applicant: Viatar LLCInventors: Stephen S. KEANEY, Katherine J. SOOJIAN, Russell W. BOWDEN, Ilan K. REICH
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Publication number: 20170173246Abstract: A device can be used to retain circulating tumor cells (CTCs). The device can include a cross-flow module with a retentate channel and a permeate channel. A filter in the cross-flow module can separate the retentate channel from the permeate channel. The filter can be constructed such that CTCs are retained in the retentate channel while other cells can pass through the filter into the permeate channel. A recirculation channel can direct a flow from an outlet of the retentate channel back to an inlet of the retentate channel to thereby concentrate CTCs in the retentate flow.Type: ApplicationFiled: December 28, 2016Publication date: June 22, 2017Applicant: Viatar LLCInventors: Cornelis Johannes Maria van RIJN, Ilan K. REICH
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Patent number: 9545471Abstract: A device can be used to retain circulating tumor cells (CTCs). The device can include a cross-flow module with a retentate channel and a permeate channel. A filter in the cross-flow module can separate the retentate channel from the permeate channel. The filter can be constructed such that CTCs are retained in the retentate channel while other cells can pass through the filter into the permeate channel. A recirculation channel can direct a flow from an outlet of the retentate channel back to an inlet of the retentate channel to thereby concentrate CTCs in the retentate flow.Type: GrantFiled: August 6, 2014Date of Patent: January 17, 2017Assignee: VIATAR LLCInventors: Cornelis Johannes Maria van Rijn, Ilan K. Reich
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Publication number: 20150041398Abstract: A device can be used to retain circulating tumor cells (CTCs). The device can include a cross-flow module with a retentate channel and a permeate channel. A filter in the cross-flow module can separate the retentate channel from the permeate channel. The filter can be constructed such that CTCs are retained in the retentate channel while other cells can pass through the filter into the permeate channel. A recirculation channel can direct a flow from an outlet of the retentate channel back to an inlet of the retentate channel to thereby concentrate CTCs in the retentate flow.Type: ApplicationFiled: August 6, 2014Publication date: February 12, 2015Inventors: Cornelis Johannes Maria van RIJN, Ilan K. REICH
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Publication number: 20140339161Abstract: A system for ultrafiltration employs a crossflow filtration module for extracting a fraction from a sample fluid (e.g., blood) and a recirculating permeate loop to produce a concurrent permeate flow through the filtration module to maintain a positive transmembrane pressure at all points of the crossflow filter. Permeate in the recirculating loop is enriched by a processing module and stabilized by removing an enriched fraction thereof. In an embodiment, the enriched fraction is concentrated plasma that is returned to a patient.Type: ApplicationFiled: October 8, 2012Publication date: November 20, 2014Applicant: The Trustees of Columbia University in the City of New YorkInventors: Edward Leonard, Michael Hill, Cees J.M. Van Rijn, Ilan K. Reich, Levy Amar
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Patent number: 8496606Abstract: A membraneless separation device can be applied to a variety of treatments, such as the ultrafiltration of blood for a patient with end stage renal disease. An ultrafiltration device can include a membraneless separation device, which separates an incoming blood flow into a substantially cytoplasmic body-free plasma flow and remaining fraction, and a dialysate-free second stage, which selectively removes excess fluid, toxins and other substances from the plasma flow and returns the processed plasma to the membraneless separation device. A treatment protocol can include ultrafiltering blood of a patient using the ultrafiltration device and performing a secondary treatment on the blood of the patient at a reduced frequency compared to the ultrafiltering. The membraneless separation device can also be applied to treatment, analysis, and/or exchange of plasma from blood, or combined with conventional dialyzers to perform dialysis on a cytoplasmic body-free plasma fraction.Type: GrantFiled: February 4, 2009Date of Patent: July 30, 2013Assignee: The Trustees of Columbia University in the City of New YorkInventors: Edward F. Leonard, Ilan K. Reich, Stanley Cortell
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Publication number: 20130102948Abstract: A blood filtration device, system, and method that can and selectively remove or reduce an unwanted, in certain cases unknown, substance from a patient's blood stream. More specifically, a specific size or size range of unwanted substance is selectively removed. The unwanted substance includes one or more of a pathogen, a toxin, an activated cell, and an administered drug. The device and system employ a microfluidic separation device that minimizes thrombogenesis and can permit the use of anticoagulants to be avoided. The device or system can be portable and can include its own power supply. Sensors in the system may monitor for the presence and/or concentration of unwanted species including pathogens or drugs and invoke a blood cleansing process responsively to the sensor signals in closed loop control process. The control may combine the infusion of therapeutic agents into the blood of a patient as well.Type: ApplicationFiled: March 24, 2011Publication date: April 25, 2013Inventors: Ilan K. Reich, Edward F. Leonard, Fred Mermelstein
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Publication number: 20120294742Abstract: A peristaltic pump with a removable pump race module has guiding channels for receiving at least a portion of a flexible fluid-carrying tubing and an adjusting device for displacing a flexible inner portion of the removable pump race module to change the compression on the fluid-carrying tubing. The arrangement of the various elements makes it particularly suitable in configurations where compactness and convenience are important considerations.Type: ApplicationFiled: December 8, 2010Publication date: November 22, 2012Applicant: The Trustees of Columbia University in the City of New YorkInventors: Ilan K. Reich, Keith McCord, Edward F. Leonard
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Publication number: 20120205306Abstract: A microfluidic separation device suitable for high throughput applications such as medical treatments, and associated methods and systems, are described. Embodiments are suitable for treatment of end stage renal disease.Type: ApplicationFiled: August 27, 2010Publication date: August 16, 2012Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Ilan K. Reich, Edward F. Leonard, Michael Hill, John Howard
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Publication number: 20110105982Abstract: A membraneless separation device can be applied to a variety of treatments, such as the ultrafiltration of blood for a patient with end stage renal disease. An ultrafiltration device can include a membraneless separation device, which separates an incoming blood flow into a substantially cytoplasmic body-free plasma flow and remaining fraction, and a dialysate-free second stage, which selectively removes excess fluid, toxins and other substances from the plasma flow and returns the processed plasma to the membraneless separation device. A treatment protocol can include ultrafiltering blood of a patient using the ultrafiltration device and performing a secondary treatment on the blood of the patient at a reduced frequency compared to the ultrafiltering. The membraneless separation device can also be applied to treatment, analysis, and/or exchange of plasma from blood, or combined with conventional dialyzers to perform dialysis on a cytoplasmic body-free plasma fraction.Type: ApplicationFiled: February 4, 2009Publication date: May 5, 2011Applicant: The Trustees of Columbia University in the City of New YorkInventors: Edward F. Leonard, Ilan K. Reich, Stanley Cortell