Abstract: The present invention provides constructs comprising a plurality of peptides capable of targeting at least two different extracellular tumor antigens and a toxin, optionally connected to an organic scaffold. Use of such constructs in treating cancer are provided as well. The invention also provides particular peptides binding certain extracellular tumor antigens as well as toxins having antitumor activity.

Abstract: The present invention provides cytotoxic peptides, analogs thereof and fragments thereof, conjugates of said peptides, analogs or fragments as well as compositions comprising same. In addition, uses of these compounds and compositions in treating cancer are provided.

Abstract: Constructs comprising a plurality of peptides are provided and their use in treating cancer. The construct optionally connected to an organic scaffold, comprise ate least one peptide capable of targeting the tumor antigen cMet, at least two peptides targeting two additional extracellular tumor antigens and a toxin. Specific peptide sequences binding to the extracellular tumor antigens cMet or EGFR are also provided.

Abstract: The present invention provides constructs comprising a plurality of peptides capable of targeting at least two different extracellular tumor antigens and a toxin, optionally connected to an organic scaffold. Use of such constructs in treating cancer are provided as well. The invention also provides particular peptides binding certain extracellular tumor antigens as well as toxins having antitumor activity.

Abstract: A system of a recombinant bacteriophage library and a target of interest complex, wherein the recombinant bacteriophage peptide library includes a plurality of peptides expressed on the surface of recombinant bacteriophages wherein each recombinant bacteriophage includes (a) a pill protein; wherein each pill protein includes (b) a peptide or polypeptide involved in an intermolecular interaction, which differs by at least one amino acid from other peptides or polypeptides in the library; and (c) a modified protease cleavage site proximal to the peptide, wherein the modified protease cleavage site is the same in each bacteriophage, the modified cleavage site having a reduced binding affinity to a protease, as compared to a non-modified cleavage site, and wherein the target of interest complex includes a protease, a flexible linker attached to the protease, and a target of interest attached to the flexible linker, wherein the target of interest participates in an intermolecular interaction.

Abstract: This invention provides, in one embodiment, a recombinant virus or a recombinant virus library wherein each virus comprises a protein involved in viral attachment or infection, a polypeptide which differs by at least a single amino acid from another peptide or polypeptide in the library, and a modified cleavage site that is proximal to the peptide and the protein, wherein the cleavage site is modified such that a compound mediating cleavage has a reduced binding affinity for it as compared to a non-modified cleavage site. The invention further provides a target of interest complex comprising a protease, a target of interest involved in an intermolecular interaction, and a flexible linker that attaches the protease and target of interest.

Abstract: This invention provides, in one embodiment, a recombinant virus or a recombinant virus library wherein each virus comprises a protein involved in viral attachment or infection, a polypeptide which differs by at least a single amino acid from another peptide or polypeptide in the library, and a modified cleavage site that is proximal to the peptide and the protein, wherein the cleavage site is modified such that a compound mediating cleavage has a reduced binding affinity for it as compared to a non-modified cleavage site. The invention further provides a target of interest complex comprising a protease, a target of interest involved in an intermolecular interaction, and a flexible linker that attaches the protease and target of interest.

Abstract: An audio switching system alternately directs an input audio signal to an audio output and to a remote puppet. The system includes an audio switching arrangement with a transmitter and a puppet including a receiver, an amplifier and a speaker. The audio switching arrangement includes an electronic switch electrically switchable between a straight-through state wherein the audio signal from the audio input is transferred to the audio output and a diverted state wherein the audio signal from the audio input is transferred to the transmitter for transmitting to the puppet. A signal processor, associated with the audio input, responds to a predefined actuation signal superimposed on the audio signal as part of the electrical signal from the audio input to switch the electronic switch from the straight-through state to the diverted state. The frequency and/or duration of the actuation signal is preferably chosen to render the actuation signal substantially non-intrusive to the hearing of the user.

Abstract: A story-telling doll includes a doll body (10) which contains a processing system (12) including at least one digital processor, a programmable data storage device (14) and an audio output device (16). At least one user-operable switch (SW1, SW2, SW3) is manually operable by manipulation of at least one region (18, 20, 22) of body (10) to provide an input signal to processing system (12). A communications unit (24), also contained within body (10), is configured to operate under control of processing unit (12) in response to the input signal to: (a) initiate a data communications link via a general purpose communications network with a remote content provider source, (b) transmit to the remote content provider a request for download of at least one data file including audio content, and (c) receive the at least one data file including audio content from the remote content provider.