Abstract: Power circuitry for cold plasma generation; optionally plasma for therapeutic use. Cold plasma generation occurs at the distal end of a catheter-like device which is flexible, narrow (e.g., less than 5 mm in diameter), and longitudinally extended to reach, e.g., 50-100 cm into body cavities. A cable used for power transmission is a part of the power generating circuit, its intrinsic impedance being a major contributor to and constraint on the time constant of an entraining RC circuit whose resonant frequency entrains the frequency of power generation. In some embodiments, inductive transformer coupling to the entraining/transmission line circuit is used to generate voltage gain. In some embodiments, transformer coupling is divided into a plurality of stages.

Abstract: An endoscopically operated plasma delivery device, in which ionization gas also suffices to provide insufflation pressure allowing the device to be maneuvered in a treated body lumen. To assist in maintaining pressure safety while avoiding interfering with the parameters of plasma generation, ionization gas evacuation is automatically adjusted in response to monitored pressure in the body lumen. In some embodiments, rapid control response is assisted by augmenting ionization gas throughput with a second gas source, and using valved switching of the proportions of gas evacuated from the two sources. In some embodiments, a faster but cruder adjustment mechanism is coupled with a slower but finer-adjusting mechanism, potentially increasing responsiveness while maintaining control of equilibrium pressures. In some embodiments, direct manual adjustment of insufflation pressure is accommodated within the operational parameters of automatically adjusting control, optionally with override.

Abstract: Systems and methods for controlling plasma dosage; particularly, in some embodiments, using small diameter intrabody plasma delivery probes. Control of administration of a selected dosage of plasma to be applied to tissue may include selection of a pattern of motion of the probe as it moves to deliver plasma: not only to where, but also for how long the probe remains and/or at what speed the probe moves. In some embodiments, feedback from measurements is used to help ensure the targeted dosage of plasma is delivered; for example measurements of power which generates plasma, and/or spectral characteristics of generated plasma. In some embodiments, a joint relationship between probe position and plasma generation exists, such that maximum power is obtained at a certain distance from the target which allows the plasma plume to fully develop, rate of plasma delivery, accordingly, may itself be adjusted by motions of the plasma delivering probe.

Abstract: Systems and methods for controlling plasma dosage; particularly, in some embodiments, using small diameter intrabody plasma delivery probes. Control of administration of a selected dosage of plasma to be applied to tissue may include selection of a pattern of motion of the probe as it moves to deliver plasma: not only to where, but also for how long the probe remains and/or at what speed the probe moves. In some embodiments, feedback from measurements is used to help ensure the targeted dosage of plasma is delivered; for example measurements of power which generates plasma, and/or spectral characteristics of generated plasma. In some embodiments, a joint relationship between probe position and plasma generation exists, such that maximum power is obtained at a certain distance from the target which allows the plasma plume to fully develop, rate of plasma delivery, accordingly, may itself be adjusted by motions of the plasma delivering probe.

Abstract: Power circuitry for non-thermal plasma generation; optionally therapeutic plasma. Non-thermal plasma is generated distally by a catheter-like device which is flexible, narrow (e.g., diameter<5 mm), and longitudinally extended to reach, e.g., 50-100 cm into body cavities. A plasma probe power transmission cable is a part of the power generating circuit, its intrinsic impedance contributing to and constraining the time constant of an entraining RC circuit whose resonant frequency entrains the frequency of power generation by feedback. Variable length, construction and/or manufacture (for example) of the plasma probe potentially lead to different time constants. In some embodiments, transformer coupling is divided into a plurality of stages, allowing the final-stage transformer inductance to be selected with sufficient headroom to allow the use of compensation componentry to mask probe variability and maintain a targeted operating frequency.

Abstract: Power circuitry for non-thermal plasma generation; optionally therapeutic plasma. Non-thermal plasma is generated distally by a catheter-like device which is flexible, narrow (e.g., diameter <5 mm), and longitudinally extended to reach, e.g., 50-100 cm into body cavities. A plasma probe power transmission cable is a part of the power generating circuit, its intrinsic impedance contributing to and constraining the time constant of an entraining RC circuit whose resonant frequency entrains the frequency of power generation by feedback. Variable length, construction and/or manufacture (for example) of the plasma probe potentially lead to different time constants. In some embodiments, transformer coupling is divided into a plurality of stages, allowing the final-stage transformer inductance to be selected with sufficient headroom to allow the use of compensation componentry to mask probe variability and maintain a targeted operating frequency.

Abstract: Power circuitry for cold plasma generation; optionally plasma for therapeutic use. Cold plasma generation occurs at the distal end of a catheter-like device which is flexible, narrow (e.g., less than 5 mm in diameter), and longitudinally extended to reach, e.g., 50-100 cm into body cavities. A cable used for power transmission is a part of the power generating circuit, its intrinsic impedance being a major contributor to and constraint on the time constant of an entraining RC circuit whose resonant frequency entrains the frequency of power generation. In some embodiments, inductive transformer coupling to the entraining/transmission line circuit is used to generate voltage gain. In some embodiments, transformer coupling is divided into a plurality of stages.

Abstract: Plasma delivery tips of medical-grade plasma generating devices are configured to exclude potential contaminants while operating within body cavities. In some embodiments, delivery tips are provided with an antechamber, which is optionally filled by pressure of ionizing gas to prevent contamination. Some embodiments are provided with one or more interior and/or exterior valves configured to prevent proximal ingress of contamination to the longitudinal position of the discharge electrode, or at all into the gas delivery lumen. In some embodiments, an expandable distal section of the plasma delivery tip acts as a valve which seals when closed, and when open expands to generate an inflated antechamber into which plasma is delivered.

Abstract: Adjustable distal tips of cold plasma generating devices configured for introduction to and operation within narrow intra-body confines. In some embodiments, a plasma delivery tip of a cold plasma generating device is expandable from a compact delivery configuration, allowing device operation with plasma plume parameters difficult to achieve within size constraints of a narrow delivery catheter and/or endoscope working channel. Additionally or alternatively, in some embodiments, operating parameters of a plasma delivery tip are adjustable to tune characteristics of the plasma plume. Adjustable parameters optionally include, for example: lumen diameter, lumen aperture shape/direction, discharge electrode geometry, dielectric barrier characteristics, and/or relative placement of these components, including placement relative to a stream of ionizing gas. In some embodiments, plasma delivery tip elements are adapted to assist device navigation and/or tissue penetration.

Abstract: Adjustable distal tips of cold plasma generating devices configured for introduction to and operation within narrow intra-body confines. In some embodiments, a plasma delivery tip of a cold plasma generating device is expandable from a compact delivery configuration, allowing device operation with plasma plume parameters difficult to achieve within size constraints of a narrow delivery catheter and/or endoscope working channel. Additionally or alternatively, in some embodiments, operating parameters of a plasma delivery tip are adjustable to tune characteristics of the plasma plume. Adjustable parameters optionally include, for example: lumen diameter, lumen aperture shape/direction, discharge electrode geometry, dielectric barrier characteristics, and/or relative placement of these components, including placement relative to a stream of ionizing gas. In some embodiments, plasma delivery tip elements are adapted to assist device navigation and/or tissue penetration.

Abstract: Adjustable distal tips of cold plasma generating devices configured for introduction to and operation within narrow intra-body confines. In some embodiments, a plasma delivery tip of a cold plasma generating device is expandable from a compact delivery configuration, allowing device operation with plasma plume parameters difficult to achieve within size constraints of a narrow delivery catheter and/or endoscope working channel. Additionally or alternatively, in some embodiments, operating parameters of a plasma delivery tip are adjustable to tune characteristics of the plasma plume. Adjustable parameters optionally include, for example: lumen diameter, lumen aperture shape/direction, discharge electrode geometry, dielectric barrier characteristics, and/or relative placement of these components, including placement relative to a stream of ionizing gas. In some embodiments, plasma delivery tip elements are adapted to assist device navigation and/or tissue penetration.

Abstract: Power circuitry for cold plasma generation; optionally plasma for therapeutic use. Cold plasma generation occurs at the distal end of a catheter-like device which is flexible, narrow (e.g., less than 5 mm in diameter), and longitudinally extended to reach, e.g., 50-100 cm into body cavities. A cable used for power transmission is a part of the power generating circuit, its intrinsic impedance being a major contributor to and constraint on the time constant of an entraining RC circuit whose resonant frequency entrains the frequency of power generation. In some embodiments, inductive transformer coupling to the entraining/transmission line circuit is used to generate voltage gain. In some embodiments, transformer coupling is divided into a plurality of stages.

Abstract: Power circuitry for non-thermal plasma generation; optionally therapeutic plasma. Non-thermal plasma is generated distally by a catheter-like device which is flexible, narrow (e.g., diameter <5 mm), and longitudinally extended to reach, e.g., 50-100 cm into body cavities. A plasma probe power transmission cable is a part of the power generating circuit, its intrinsic impedance contributing to and constraining the time constant of an entraining RC circuit whose resonant frequency entrains the frequency of power generation by feedback. Variable length, construction and/or manufacture (for example) of the plasma probe potentially lead to different time constants. In some embodiments, transformer coupling is divided into a plurality of stages, allowing the final-stage transformer inductance to be selected with sufficient headroom to allow the use of compensation componentry to mask probe variability and maintain a targeted operating frequency.

Abstract: A threaded medical implant comprising a biocomposite, said biocomposite comprising a polymer and a plurality of reinforcement fibers, wherein a weight percentage of a mineral composition within the biocomposite medical implant is in the range of 30-60%, wherein an average diameter of said fibers is in a range of 1-100 microns, said medical implant being threaded with a plurality of threads; wherein said fibers comprise a plurality of helical fibers and a plurality of longitudinal fibers; wherein a weight to weight percent ratio of said helical to said longitudinal fibers is from 90:10 to 10:90.

Abstract: A threaded medical implant comprising a biocomposite, said biocomposite comprising a polymer and a plurality of reinforcement fibers, wherein a weight percentage of a mineral composition within the biocomposite medical implant is in the range of 30-60%, wherein an average diameter of said fibers is in a range of 1-100 microns, said medical implant being threaded with a plurality of threads; wherein said fibers comprise a plurality of helical fibers and a plurality of longitudinal fibers; wherein a weight to weight percent ratio of said helical to said longitudinal fibers is from 90:10 to 10:90.

Abstract: A medical implant comprising a plurality of fiber bundles, each bundle comprising a polymer and a plurality of uni-directionally aligned continuous reinforcement fibers.