Abstract: The invention provides method for treating Raynaud's conditions such as Raynaud's syndrome, Raynaud's phenomenon, and Raynaud's disease by administering to a subject in need a pharmaceutical or a dietary supplement comprising grape cell culture grown in vitro. Further provided method for treating erectile dysfunction by administering to a subject in need a pharmaceutical or a dietary supplement comprising grape cell culture grown in vitro. For example, red grape cell culture grown in vitro in bioreactors are administered to treat or reduce the severity of a symptom of a Raynaud's condition and/or to ameliorate erectile dysfunction.