Abstract: Disclosed are compositions for use in the simultaneous removal of endotoxins from dialysate and uremic solutes from blood during the treatment of patients. The treatment is selected from the group consisting of hemodialysis and hemodiafiltration. The compositions comprise sorbent particles embedded in a membrane comprising a polymer and a hydrophilic additive.

Abstract: The present invention relates to a method for preparing a membrane comprising sorbent particles that bind urea. The invention also relates to the sorbent-comprising membranes per se, and to methods of using the membranes. The membranes are useful for undergoing subsequent reactions with small molecules such as urea, for instance to remove urea from a solution.

Abstract: Disclosed are hollow fibers suitable for use in dialysis in an outside-in configuration. For such fibers, it is desirable that the fiber have a low albumin sieving coefficient and have a permeability high enough to be considered a High Flux dialyzer, and it is desirable that the outer (blood-facing) surface have a sufficiently small roughness and be hydrophilic. It is desirable that there be a selective layer on the outer surface and, interiorly of that, a porous structurally supportive region, which may contain elongated macrovoids. Such a fiber may be spun through a triple-concentric spinneret that produces a bore liquid surrounded by dope surrounded by a shower. The shower and the coagulation bath may be pure water, which is a non-solvent. The process may be performed at room temperature. Spinning parameters are discussed.

Abstract: Disclosed are compositions for use in the simultaneous removal of endotoxins from dialysate and uremic solutes from blood during the treatment of patients. The treatment is selected from the group consisting of hemodialysis and hemodiafiltration. The compositions comprise sorbent particles embedded in a membrane comprising a polymer and a hydrophilic additive.