Patents by Inventor Ilaria Munari

Ilaria Munari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing enantiomerically enriched oxamides
    Patent number: 9481686
    Abstract: The present invention relates to a chiral oxamide of formula (I) useful as an intermediate in the preparation of dorzolamide, and to the preparation thereof. The invention also relates to the preparation of dorzolamide, to the hydrochloride salt thereof, and to the active ingredient contained in a drug useful in the treatment of glaucoma, by means of the intermediate of formula (I).
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: November 1, 2016
    Assignee: ZACH SYSTEM S.P.A.
    Inventors: Raffaella Volpicelli, Antonio Nardi, Mauro Andretto, Ilaria Munari, Roberto Brescello, Anna Smaniotto, Livius Cotarca, Massimo Verzini
  • Process for preparing a ketosulfone derivative
    Patent number: 9085532
    Abstract: The present invention relates to a process for preparing a ketosulfone derivative and, more particularly, to an improved method for synthesizing 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]ethanone by means of Pd-catalized alpha arylation process of a heteroaromatic ketone derivative.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: July 21, 2015
    Assignee: ZACH SYSTEM S.P.A.
    Inventors: Elisa Melotto, Ivan Michieletto, Vincenzo Frega, Livius Cotarca, Massimo Verzini, Franco Massaccesi, Ilaria Munari
  • Process for Preparing Enantiomerically Enriched Oxamides
    Publication number: 20150191485
    Abstract: The present invention relates to a chiral oxamide of formula (I) useful as an intermediate in the preparation of dorzolamide, and to the preparation thereof. The invention also relates to the preparation of dorzolamide, to the hydrochloride salt thereof, and to the active ingredient contained in a drug useful in the treatment of glaucoma, by means of the intermediate of formula (I).
    Type: Application
    Filed: June 28, 2013
    Publication date: July 9, 2015
    Inventors: Raffaella Volpicelli, Antonio Nardi, Mauro Andretto, Ilaria Munari, Roberto Brescello, Anna Smaniotto, Livius Cotarca, Massimo Verzini
  • The Process For Preparing a Ketosulfone Derivative
    Publication number: 20150133671
    Abstract: The present invention relates to a process for preparing a ketosulfone derivative and, more particularly, to an improved method for synthesising 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]ethanone by means of Pd-catalysed alpha arylation process of a heteroaromatic ketone derivative.
    Type: Application
    Filed: March 8, 2013
    Publication date: May 14, 2015
    Inventors: Elisa Melotto, Ivan Michieletto, Vincenzo Frega, Livius Cotarca, Massimo Verzini, Franco Massaccesi, Ilaria Munari
  • Process for preparing nebivolol
    Patent number: 8084629
    Abstract: The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a diastereoisomerically pure compound of RS/SR configuration characterized in that said reduction is carried out by the use of (+)-B-chlorodiisopinocampheylborane or (?)-B-chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: December 27, 2011
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Franco Massaccesi, Ilaria Munari, Livius Cotarca, Johnny Foletto
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20110021793
    Abstract: The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a di-astereoisomerically pure compound of RS/SR configuration characterized in that said reduction is carried out by the use of (+)-B-chlorodiisopinocampheylborane or (?)-B-chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol.
    Type: Application
    Filed: March 16, 2009
    Publication date: January 27, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Franco Massaccesi, Ilaria Munari, Livius Cotarca, Johnny Foletto