Patents by Inventor Ilaria Rebay

Ilaria Rebay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies to human notch proteins and fragments
    Patent number: 6090922
    Abstract: The present invention relates to nucleotide sequences of the human Notch and Delta genes, and amino acid sequences of their encoded proteins, as well as fragments thereof containing an antigenic determinant or which are functionally active. The invention is also directed to fragments (termed herein "adhesive fragments"), and the sequences thereof, of the proteins ("toporythmic proteins") encoded by toporythmic genes which mediate homotypic or heterotypic binding to toporythmic proteins. Toporythmic genes, as used herein, refers to the genes Notch, Delta, and Serrate, as well as other members of the Delta/Serrate family which may be identified, e.g., by the methods described herein. Analogs and derivatives of the adhesive fragments which retain binding activity are also provided. Antibodies to human Notch and to adhesive fragments are additionally provided.
    Type: Grant
    Filed: July 11, 1997
    Date of Patent: July 18, 2000
    Assignee: Yale University
    Inventors: Spyridon Artavanis-Tsakonas, Richard Grant Fehon, Ilaria Rebay
  • Serrate fragments and derivatives
    Patent number: 5856441
    Abstract: The present invention relates to sequences of the serrate amino acid sequence as well as fragments thereof, and fragments which retain binding activity are also provided.
    Type: Grant
    Filed: November 28, 1994
    Date of Patent: January 5, 1999
    Assignee: Yale University
    Inventors: Spyridon Artavanis-Tsakonas, Richard Grant Fehon, Ilaria Rebay
  • Human notch and delta, binding domains in toporythmic proteins, and methods based thereon
    Patent number: 5789195
    Abstract: The present invention relates to nucleotide sequences of the human Notch and Delta genes, and amino acid sequences of their encoded proteins, as well as fragments thereof containing an antigenic determinant or which are functionally active. The invention is also directed to fragments (termed herein "adhesive fragments"), and the sequences thereof, of the proteins ("toporythmic proteins") encoded by toporythmic genes which mediate homotypic or heterotypic binding to toporythmic proteins. Toporythmic genes, as used herein, refers to the genes Notch, Delta, and Serrate, as well as other members of the Delta/Serrate family which may be identified, e.g., by the methods described herein. Analogs and derivatives of the adhesive fragments which retain-binding activity are also provided. Antibodies to human Notch and to adhesive fragments are additionally provided.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 4, 1998
    Assignee: Yale University
    Inventors: Spyridon Artavanis-Tsakonas, Marc Alan Telander Muskavitch, Richard Grant Fehon, Ilaria Rebay, Christine Marie Blaumueller, Scott Brockwell Shepard
  • Human Notch and Delta binding domains in toporythmic proteins, and methods based thereon
    Patent number: 5648464
    Abstract: The present invention relates to nucleotide sequences of the human Notch and Delta genes, and amino acid sequences of their encoded proteins, as well as fragments thereof containing an antigenic determinant or which are functionally active. The invention is also directed to fragments (termed herein "adhesive fragments"), and the sequences thereof, of the proteins ("toporythmic proteins") encoded by toporythmic genes which mediate homotypic or heterotypic binding to toporythmic proteins. Toporythmic genes, as used herein, refers to the genes Notch, Delta, and Serrate, as well as other members of the Delta/Serrate family which may be identified, e.g., by the methods described herein. Analogs and derivatives of the adhesive fragments which retain binding activity are also provided. Antibodies to human Notch and to adhesive fragments are additionally provided.
    Type: Grant
    Filed: June 23, 1994
    Date of Patent: July 15, 1997
    Assignee: Yale University
    Inventors: Spyridon Artavanis-Tsakonas, Richard Grant Fehon, Ilaria Rebay, Christine Marie Blaumueller