Patents by Inventor Ilaria Sciamanna

Ilaria Sciamanna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal antibody to human line-1 ORF2 protein and method for early detection of transforming cells in pre-neoplastic tissues of a human subject
    Patent number: 10214591
    Abstract: The present disclosure relates to a monoclonal antibody specifically binding to human Long Interspersed Element-1 ORF2 encoded protein (L1-ORF2p) obtained from hybridoma chA1, and derivatives and uses thereof, including for prediction of response of cancer patients to NNRTI treatments. It also relates to a method for early detection of cell transformation in pre-neoplastic tissues of a human subject, comprising detecting in cells of a pre-neoplastic tissue sample from said subject the expression of L1-ORF2p, wherein the expression of L1-ORF2p indicates the presence of cell transformation in said pre-neoplastic tissues. It also relates to a method for detecting progression of colon adenoma in a human subject suffering from colon adenoma, based on detection of an increase of L1-ORF2p expression.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: February 26, 2019
    Inventors: Corrado Spadafora, Ilaria Sciamanna, Chiara De Luca, Paola Sinibaldi-Vallebona, Fiorella Guadagni, Gerald Schumann, Enrico Garaci
  • Retrotransposon Inhibition in Therapy
    Publication number: 20090203892
    Abstract: RNA interference is useful in the treatment of cancerous lesions, wherein the RNA recognises a portion of at least one LINE-I repeat element.
    Type: Application
    Filed: December 30, 2005
    Publication date: August 13, 2009
    Applicants: ISTITUTO SUPERIORE DI SANITA
    Inventors: Enrico Garaci, Paola Sinibaldi, Corrado Spadafora, Carmine Pittoggi, Ilaria Sciamanna, Cristina Mearelli