Abstract: A composition is described for the treatment of infections caused by pathogens, such as viruses, bacteria, fungi or yeasts. In particular, the composition of the invention comprises a synergistic association of i) active ingredient comprising lactoferrin or at least one peptide comprising lactoferricin, polylysin, natamycin or their mixture, or a mixture of lactoferrin and said at least one peptide, and ii) at least one plant extract comprising antioxidants selected from catechins, polyphenols and their mixtures. This synergistic association has been shown to be significantly active against these pathogens.