Patents by Inventor Ildefonso Suarez

Ildefonso Suarez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Flagellin-based adjuvants and vaccines
    Patent number: 7404963
    Abstract: The present invention provides adjuvants, vaccines and related methods that are useful in eliciting immune responses, particularly immune responses against tumor antigens. We discovered that flagellin is capable of inhibiting tolerance when it is administered in conjunction with a tolerogenic antigen. This effect is likely mediated by the ability of flagellin to induce IL-12 while keeping IL-10 levels low. Furthermore, flagellin can be provided in an extended-releasing manner by using a flagellin-expressing cell. Preferably, the flagellin-expressing cell is treated such that it is no longer capable of replicating, yet retaining the ability to express flagellin, such as by lethal irradiation.
    Type: Grant
    Filed: October 3, 2005
    Date of Patent: July 29, 2008
    Assignee: The University of South Florida
    Inventors: Eduardo M. Sotomayor, Ildefonso Suarez
  • Flagellin-based adjuvants and vaccines
    Publication number: 20060088555
    Abstract: The present invention provides adjuvants, vaccines and related methods that are useful in eliciting immune responses, particularly immune responses against tumor antigens. We discovered that flagellin is capable of inhibiting tolerance when it is administered in conjunction with a tolerogenic antigen. This effect is likely mediated by the ability of flagellin to induce IL-12 while keeping IL-10 levels low. Furthermore, flagellin can be provided in an extended-releasing manner by using a flagellin-expressing cell. Preferably, the flagellin-expressing cell is treated such that it is no longer capable of replicating, yet retaining the ability to express flagellin, such as by lethal irradiation.
    Type: Application
    Filed: October 3, 2005
    Publication date: April 27, 2006
    Applicant: University of South Florida
    Inventors: Eduardo Sotomayor, Ildefonso Suarez