Abstract: A microfluidic device includes a device body defining a microfluidic pathway including a first channel, a second channel downstream of the first channel, and a junction including a transition between the first channel and the second channel. The transition is configured to inhibit fluid entering the transition from the first channel from forming a meniscus across the second channel, thereby inhibiting capillary-driven flow into the second channel. The microfluidic device further includes a valve that, when activated while capillary-driven flow of the fluid is inhibited at the transition, induces capillary-driven flow through the second channel by facilitating formation of the meniscus.

Abstract: An assay device includes a colorimetric testing assembly including a detection area, a fluid inlet, and a microfluidic network including a first path extending to the detection area and a second path extending to the detection area. When a fluid (e.g., a buffer fluid or a combined buffer and sample solution) is provided to the fluid inlet, a first portion of the fluid rehydrates a first dried reagent (e.g., a dried enzyme label) disposed along the first path to produce a first rehydrated reagent and a second portion of the fluid rehydrates a second dried reagent (e.g., a dried substrate) to produce a second rehydrated reagent. The first rehydrated reagent and the second rehydrated reagent are then sequentially delivered to the detection area by capillary-driven flow to perform the assay.

Abstract: An assay device includes an electrochemical testing assembly having a test channel including a capture reagent selected to capture a target analyte and an electrode having a surface in communication with the test channel. The assay device further includes a microfluidic network in communication with the test channel, a buffer fluid inlet in communication with the microfluidic network, and a detection reagent disposed within the microfluidic network. When a buffer fluid is provided to the buffer fluid inlet, the buffer fluid transports the detection reagent to the test channel by capillary-driven flow, and wherein the electrode is configured to measure an electrical response indicating capture of the target analyte by the capture reagent after transportation of the detection reagent to the test channel.

Abstract: An electronic circuit includes an analog to digital converter (ADC) and a noise coupling filter. The ADC generates a digital output signal based on a first analog signal and a second analog signal. The noise coupling filter generates the second analog signal to be fed back for an input to the ADC, based on a first quantization error signal associated with converting the first analog signal to the digital output signal. The noise coupling filter performs noise shaping on a digital error signal derived from the quantization error signal and generates the second analog signal from a result of the noise shaping, using a clock in the digital domain.

Abstract: An electronic circuit includes an analog to digital converter (ADC) and a noise coupling filter. The ADC generates a digital output signal based on a first analog signal and a second analog signal. The noise coupling filter generates the second analog signal to be fed back for an input to the ADC, based on a first quantization error signal associated with converting the first analog signal to the digital output signal. The noise coupling filter performs noise shaping on a digital error signal derived from the quantization error signal and generates the second analog signal from a result of the noise shaping, using a clock in the digital domain.