Abstract: The present invention relates to Pseudomonas sp. YS-180 having a capability of producing a docosahexaenoic acid and a method for the production of DHA using such a microorganism. Pseudomonas sp. YS-180 was isolated and identified from the intestine of fishes by investigating the morphological, culturing, and physiological characteristics of a strain excellent in a DHA-producing capability. By TLC and GC, Pseudomonas sp. YS-180 according to the present invention was confirmed that it produced the greatest amount of DHA when it was shaking-cultured in a culture containing glucose 2% (w/v), a yeast extract 2% (w/v), and sea water 20%(v/v). Optimal conditions for producing DHA were a pH of 6.0, and a temperature of 20° C. Under these conditions a DHA production was 96.7 mg/L, and a biomass growth was 7.8 g/L.

Abstract: This invention relates to new pyrrolidine derivatives represented by formula (I) as below, having superior pharmacological activity as antihypertensive agents ##STR1## wherein R.sup.1 is saturated or unsaturated alkyl of 2 to 20 carbon atoms, or aryl group;R.sup.2 is saturated or unsaturated alkyl of 1 to 17 carbon atoms, or aryl group;R.sup.3 is hydrogen atom, saturated or unsaturated alkyl of 1 to 20 carbon atoms, or aryl group or its derivatives: andX is oxygen or sulfur atom.