Patents by Inventor Iliya Vassilev Ognyanov

Iliya Vassilev Ognyanov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of dihydroartemisinin hemisuccinate
    Patent number: 5654446
    Abstract: Dihydroartemisinin hemisuccinate is prepared by acylation of dihydroartemisinin with 1.0 to 1.3 molar equivalents of succinic anhydride in the presence of 0.5 to 1.5 molar equivalents of tri(C.sub.1 -C.sub.3 -alkyl)amine in a low-boiling, neutral, water-miscible, inert organic solvent or solvent mixture and subsequent isolation of the product at pH 5-8. The product is obtained directly in crystalline form and high yield.
    Type: Grant
    Filed: March 27, 1996
    Date of Patent: August 5, 1997
    Assignee: Mepha AG
    Inventors: Iliya Vassilev Ognyanov, Angel Nikolov Konakchiev, Ralph Hanni