Patents by Inventor Ilkka Larma

Ilkka Larma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stable compositions comprising levosimendan and alginic acid
    Patent number: 6531458
    Abstract: The present invention relates to pharmaceutical compositions of levosimendan comprising alginic acid for improving the stability of levosimendan in the compositions. Levosimendan is useful in the treatment of congestive heart failure.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: March 11, 2003
    Assignee: Orion Corporation
    Inventors: Ilkka Larma, Maarit Bäckman
  • Transmucosal formulations of levosimendan
    Patent number: 6399610
    Abstract: A method of administering transmucosally, particularly to oral or nasal mucosa, levosimendan or a pharmaceutically acceptable salt thereof to a patient. The method comprises contacting an intact mucous membrane with a source of levosimendan, and maintaining said source with said mucous membrane for a sufficient time period to deliver levosimendan to the patient. Transmucosal preparations of levosimendan are also described. Levosimendan is useful in the treatment of heart failure.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: June 4, 2002
    Assignee: Orion Corporation
    Inventors: Kauko Kurkela, Martti Marvola, Ilkka Larma, Raimo Virtanen, Marianne Karlsson
  • Oral compositions of levosimendan
    Patent number: 6355269
    Abstract: A composition for oral administration comprising a substantially pure crystalline polymorphic form (I) of levosimendan as an active ingredient together with a pharmaceutically acceptable carrier is described. Polymorphic form (I) of levosimendan is rapidly absorbed from the gastrointestinal tract and is useful in the treatment of congestive heart disease.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: March 12, 2002
    Assignee: Orion Corporation
    Inventors: Maarit Backman, Ilkka Larma, Saila Antila, Lasse Lehtonen
  • Composition for the oral administration of pharmaceuticals
    Patent number: 4935247
    Abstract: The invention relates to a new composition for use on a pharmaceutical granule. The composition is three-layered, comprising as the innermost layer a substantially pure fat, as the middle layer a mixture of fat and polymer, and as the outermost layer again a substantially pure fat.The composition according to the invention produces a preparation which is tasteless, especially when administered in the form of a powder or a mixture, even if the phrmaceutical to be dosed has a bad taste. Also, the preparation keeps well in mixture, and it enables a pharmaceutical to be transported past the stomach for release/absorption at the beginning of the small intestine.
    Type: Grant
    Filed: May 6, 1988
    Date of Patent: June 19, 1990
    Assignee: Orion-Yhtyma Oy
    Inventors: Esko Marttila, Ilkka Larma, Kari Vahervuo, Jaakko Uotila