Patents by Inventor Ilona Domraceva

Ilona Domraceva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AROMATIC SULPHONAMIDES DERIVATIVES THAT INHIBITS PDI A3, THEIR SYNTHESIS AND USE
    Publication number: 20230069886
    Abstract: The invention relates to a new group of aromatic sulphonamides derivatives of formula (I) and their synthesis and use for modulation of the activity of protein disulfide isomerase (PDI). More particularly, the invention provides small molecule inhibitors of PDI A3 that display antiplatelet, antithrombotic and anticancer activities.
    Type: Application
    Filed: January 10, 2020
    Publication date: March 9, 2023
    Inventors: Stefan CHLOPICKI, Ivars KALVINS, Kamil PRZYBOROWSKI, Marta STOJAK, Victor ANDRIANOV, Ilona DOMRACEVA, Iveta KANEPE-LAPSA, Diana ZELENCOVA, Joanna WIETRZYK, Eliza TURLEJ, Martyna STACHOWICZ, Joanna JAROSZ, Magdalena MILCZAREK, Karol KRAMKOWSKI
  • AROMATIC SULPHONAMIDES DERIVATIVES THAT INHIBITS PDI A3, THEIR SYNTHESIS AND USE
    Publication number: 20230039836
    Abstract: The invention relates to a new group of aromatic sulphonamides derivatives of formula (I) and their synthesis and use for modulation of the activity of protein disulfide isomerase (PDI). More particularly, the invention provides small molecule inhibitors of PDI A1 that display antiplatelet, antithrombotic and anticancer activities.
    Type: Application
    Filed: January 10, 2020
    Publication date: February 9, 2023
    Inventors: Ivars KALVINS, Stefan CHLOPICKI, Marta STOJAK, Victor ANDRIANOV, Ilona DOMRACEVA, Iveta KANEPE-LAPSA, Diana ZELENCOVA, Joanna WIETRZYK, Eliza TURLEJ, Martyna STACHOWICZ, Joanna JAROSZ, Magdalena MILCZAREK, Karol KRAMKOWSKI
  • SELENOPHENOCHROMENE HYDROXAMIC ACIDS, PREPARATION AND USE AS ANGIOGENESIS INHIBITORS
    Publication number: 20210403486
    Abstract: The present invention relates to a novel selenophenochromene hydroxamic acids as angiogenesis inhibitors, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment or prevention of various diseases and disorders by administration of such substances.
    Type: Application
    Filed: December 18, 2018
    Publication date: December 30, 2021
    Inventors: Pavels Arsenjans, Jelena Vasiljeva, Ilona Domraceva
  • Pharmaceutical combination of 5-fluorouracil and derivate of 1,4-dihydropyridine and its use in the treatment of cancer
    Patent number: 8492413
    Abstract: New compounds of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ester type having general formula I wherein R is a lower alkyl group, which is methyl or ethyl R1 and R2 is sodium carboxylate-methyl ester, having synergistic cytotoxic effect combined with 5-fluorouracil.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: July 23, 2013
    Assignee: JSC Grindeks
    Inventors: Gunars Duburs, Egils Bisenieks, Irina Sestakova, Ivars Kalvinsh, Brigita Vigante, Janis Uldrikis, Ilona Domraceva, Elina Jascenko, Janis Poikans, Imanta Bruvere, Ilmars Stonans
  • PHARMACEUTICAL COMBINATION OF 5-FLUOROURACIL AND DERIVATE OF 1,4-DIHYDROPYRIDINE AND ITS USE IN THE TREATMENT OF CANCER
    Publication number: 20120022088
    Abstract: New compounds of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ester type having general formula I wherein R is a lower alkyl group, which is methyl or ethyl R1 and R2 is sodium carboxylate-methyl ester, having synergistic cytotoxic effect combined with 5-fluorouracil.
    Type: Application
    Filed: March 11, 2010
    Publication date: January 26, 2012
    Applicant: JSC GRINDEKS
    Inventors: Gunars Duburs, Egils Bisenieks, Irina Sestakova, Ivars Kalvinsh, Brigita Vigante, Janis Uldrikis, Ilona Domraceva, Elina Jascenko, Janis Poikans, Imanta Bruvere, Ilmars Stonans