Patents by Inventor Ilse A. Tyler

Ilse A. Tyler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHETIC NUCLEIC ACID CONTROL MOLECULES
    Publication number: 20230357863
    Abstract: The present invention provides synthetic DNA strands that find use as controls or in nucleic acid testing methods. In particular, provided herein are synthetic DNA strands of known composition for use as control molecules in stool DNA testing, e.g., of mutations and/or methylation of DNA isolated from stool samples.
    Type: Application
    Filed: May 1, 2023
    Publication date: November 9, 2023
    Inventors: Ilse A. Tyler, Keith Yaeger, Michael J. Domanico, Hatim Allawi, Graham P. Lidgard
  • Synthetic nucleic acid control molecules
    Patent number: 11674186
    Abstract: The present invention provides synthetic DNA strands that find use as controls or in nucleic acid testing methods. In particular, provided herein are synthetic DNA strands of known composition for use as control molecules in stool DNA testing, e.g., of mutations and/or methylation of DNA isolated from stool samples.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: June 13, 2023
    Assignee: Exact Sciences Corporation
    Inventors: Ilse A. Tyler, Keith Yaeger, Michael J. Domanico, Hatim Allawi, Graham P. Lidgard
  • SYNTHETIC NUCLEIC ACID CONTROL MOLECULES
    Publication number: 20210172023
    Abstract: The present invention provides synthetic DNA strands that find use as controls or in nucleic acid testing methods. In particular, provided herein are synthetic DNA strands of known composition for use as control molecules in stool DNA testing, e.g., of mutations and/or methylation of DNA isolated from stool samples.
    Type: Application
    Filed: December 3, 2020
    Publication date: June 10, 2021
    Inventors: Ilse A. Tyler, Keith Yaeger, Michael J. Domanico, Hatim Allawi, Graham P. Lidgard
  • Synthetic nucleic acid control molecules
    Patent number: 10889867
    Abstract: The present invention provides synthetic DNA strands that find use as controls or in nucleic acid testing methods. In particular, provided herein are synthetic DNA strands of known composition for use as control molecules in stool DNA testing, e.g., of mutations and/or methylation of DNA isolated from stool samples.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: January 12, 2021
    Inventors: Ilse A. Tyler, Keith Yaeger, Michael J. Domanico, Hatim Allawi, Graham P. Lidgard
  • SYNTHETIC NUCLEIC ACID CONTROL MOLECULES
    Publication number: 20190144948
    Abstract: The present invention provides synthetic DNA strands that find use as controls or in nucleic acid testing methods. In particular, provided herein are synthetic DNA strands of known composition for use as control molecules in stool DNA testing, e.g., of mutations and/or methylation of DNA isolated from stool samples.
    Type: Application
    Filed: October 23, 2018
    Publication date: May 16, 2019
    Inventors: Ilse A. Tyler, Keith Yaeger, Michael J. Domanico, Hatim Allawi, Graham P. Lidgard
  • Multiple-control calibrators for DNA quantitation
    Patent number: 10253358
    Abstract: The present invention provides DNA plasmids that find use as calibrators or reference standards for calculating DNA quantities in a sample. In particular, provided herein are DNA plasmids that contain multiple control fragments, and methods of their use in DNA quantitation.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: April 9, 2019
    Assignee: EXACT SCIENCES DEVELOPMENT COMPANY, LLC
    Inventors: Michael Domanico, Ilse A. Tyler, Brian Aizenstein, Hatim Allawi, Graham P. Lidgard
  • Synthetic nucleic acid control molecules
    Patent number: 10138524
    Abstract: The present invention provides synthetic DNA strands that find use as controls or in nucleic acid testing methods. In particular, provided herein are synthetic DNA strands of known composition for use as control molecules in stool DNA testing, e.g., of mutations and/or methylation of DNA isolated from stool samples.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: November 27, 2018
    Assignee: EXACT SCIENCES DEVELOPMENT COMPANY, LLC
    Inventors: Ilse A. Tyler, Keith Yaeger, Michael J. Domanico, Hatim Allawi, Graham P. Lidgard
  • SYNTHETIC NUCLEIC ACID CONTROL MOLECULES
    Publication number: 20160312299
    Abstract: The present invention provides synthetic DNA strands that find use as controls or in nucleic acid testing methods. In particular, provided herein are synthetic DNA strands of known composition for use as control molecules in stool DNA testing, e.g., of mutations and/or methylation of DNA isolated from stool samples.
    Type: Application
    Filed: December 19, 2014
    Publication date: October 27, 2016
    Inventors: Ilse A. Tyler, Keith Yaeger, Michael J. Domanico, Hatim Allawi, Graham P. Lidgard
  • MULTIPLE-CONTROL CALIBRATORS FOR DNA QUANTITATION
    Publication number: 20160273030
    Abstract: The present invention provides DNA plasmids that find use as calibrators or reference standards for calculating DNA quantities in a sample. In particular, provided herein are DNA plasmids that contain multiple control fragments, and methods of their use in DNA quantitation.
    Type: Application
    Filed: November 4, 2014
    Publication date: September 22, 2016
    Applicant: Exact Sciences Corporation
    Inventors: Michael Domanico, Ilse A. Tyler, Brian Aizenstein, Hatim Allawi, Graham P. Lidgard