Patents by Inventor Ilse De Lange

Ilse De Lange has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell modification method using essential genes as markers and optionally recycling these
    Patent number: 9951339
    Abstract: The invention relates to a method for modification of a host cell at a target locus, which method comprises: providing a host cell comprising, at a first locus, at least two site-specific recombination sites and a nucleic acid having an essential function or encoding a product having an essential function; introducing into the host cell, at the target locus, a further nucleic acid having the essential function or encoding for a product having the essential function; and carrying out recombination at the first locus via the at least two site-specific recombination sites, so that the nucleic acid having an essential function or encoding a product having an essential function is rendered non-functional, thereby to modify the host cell at the target locus. The invention also relates to a cell obtainable by a method of the invention.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: April 24, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Ilse De Lange, Bernard Meijrink, Johannes Andries Roubos, Siew-loon Ooi
  • Host cell for the production of a compound of interest
    Patent number: 9322045
    Abstract: The present invention relates to a recombinant host cell for the production of a compound of interest. The invention further relates to a method for the production of such host cell. The invention further relates to the production of a compound of interest. The invention further relates to isolated polynucleotides and vectors and host cells comprising said polynucleotides.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: April 26, 2016
    Assignee: DSM IP ASSETS B.V.
    Inventors: Noël Nicolaas Maria Elisabeth Van Peij, Herman Jan Pel, Thibaut José Wenzel, Adriana Marina Riemens, Ilse De Lange
  • Asparaginase enzyme variants and uses thereof
    Patent number: 9127266
    Abstract: The present invention relates to newly identified asparaginase polypeptide variants of SEQ ID NO: 3 and to polynucleotide sequences that encode such novel asparaginase variants. Furthermore the invention relates to the use of these novel asparaginase variants in industrial processes.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: September 8, 2015
    Assignee: DSM IP ASSETS B.V.
    Inventors: Jan Metske Van Der Laan, Mark Cristiaan Stor, Ilse De Lange, Lisette Mohrmann
  • CELL MODIFICATION METHOD USING ESSENTIAL GENES AS MARKERS AND OPTIONALLY RECYCLING THESE
    Publication number: 20150225728
    Abstract: The invention relates to a method for modification of a host cell at a target locus, which method comprises: providing a host cell comprising, at a first locus, at least two site-specific recombination sites and a nucleic acid having an essential function or encoding a product having an essential function; introducing into the host cell, at the target locus, a further nucleic acid having the essential function or encoding for a product having the essential function; and carrying out recombination at the first locus via the at least two site-specific recombination sites, so that the nucleic acid having an essential function or encoding a product having an essential function is rendered non-functional, thereby to modify the host cell at the target locus. The invention also relates to a cell obtainable by a method of the invention.
    Type: Application
    Filed: September 19, 2013
    Publication date: August 13, 2015
    Inventors: Ilse De Lange, Bernard Meijrink, Johannes Andries Roubos, Siew-loon Ooi
  • HOST CELL FOR THE PRODUCTION OF A COMPOUND OF INTEREST
    Publication number: 20140248662
    Abstract: The present invention relates to a recombinant host cell for the production of a compound of interest. The invention further relates to a method for the production of such host cell. The invention further relates to the production of a compound of interest. The invention further relates to isolated polynucleotides and vectors and host cells comprising said polynucleotides.
    Type: Application
    Filed: April 10, 2014
    Publication date: September 4, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Noël Nicolaas Maria Elisabeth VAN PEIJ, Herman Jan PEL, Thibaut Jose WENZEL, Adriana Marina RIEMENS, Ilse DE LANGE
  • Host cell for the production of a compound of interest
    Patent number: 8734782
    Abstract: The present invention relates to a recombinant host cell for the production of a compound of interest. The invention further relates to a method for the production of such host cell. The invention further relates to the production of a compound of interest. The invention further relates to isolated polynucleotides and vectors and host cells comprising said polynucleotides.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: May 27, 2014
    Assignee: DSM IP Assets B.V.
    Inventors: Noël Nicolass Maria Elisabeth Van Peij, Herman Jan Pel, Thibaut José Wenzel, Adriana Marina Riemens, Ilse De Lange
  • ASPARAGINASE ENZYME VARIANTS AND USES THEREOF
    Publication number: 20140099401
    Abstract: The present invention relates to newly identified asparaginase polypeptide variants of SEQ ID NO: 3 and to polynucleotide sequences that encode such novel asparaginase variants. Furthermore the invention relates to the use of these novel asparaginase variants in industrial processes.
    Type: Application
    Filed: November 8, 2013
    Publication date: April 10, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Jan Metske VAN DER LAAN, Mark Cristiaan STOR, Ilse DE LANGE, Lisette MOHRMANN
  • NOVEL ASPARAGINASES AND USES THEREOF
    Publication number: 20130023029
    Abstract: The present invention relates to an asparaginase having the width of the pH activity profile which is at least 3.5. Furthermore the invention relates to newly identified asparaginase polypeptide according to any one of SEQ ID NO: 2 or SEQ ID NO: 4 and to variants thereof and to polynucleotide sequences that encode such novel asparaginase variants. Furthermore the invention relates to the use of these novel asparaginase variants in industrial processes.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 24, 2013
    Applicant: DSM IP ASSETS B.V.
    Inventors: Jan Metske VAN DER LAAN, Mark Cristiaan STOR, Ilse DE LANGE, Lisette MOHRMANN
  • Asparaginases and uses thereof
    Patent number: 8323948
    Abstract: The present invention relates to an asparaginase having the width of the pH activity profile which is at least 3.5. Furthermore the invention relates to newly identified asparaginase polypeptide according to any one of SEQ ID NO: 2 or SEQ ID NO: 4 and to variants thereof and to polynucleotide sequences that encode such novel asparaginase variants. Furthermore the invention relates to the use of these novel asparaginase variants in industrial processes.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: December 4, 2012
    Assignee: DSM IP Assets B.V.
    Inventors: Jan Metske Van Der Laan, Mark Cristiaan Stor, Ilse De Lange, Lisette Mohrmann
  • HOST CELL FOR THE PRODUCTION OF A COMPOUND OF INTEREST
    Publication number: 20120190066
    Abstract: The present invention relates to a recombinant host cell for the production of a compound of interest. The invention further relates to a method for the production of such host cell. The invention further relates to the production of a compound of interest. The invention further relates to isolated polynucleotides and vectors and host cells comprising said polynucleotides.
    Type: Application
    Filed: July 1, 2010
    Publication date: July 26, 2012
    Applicant: DSM IP ASSETS B.V.
    Inventors: Noël Nicolass Maria Elisabeth Van Peij, Herman Jan Pel, Thibaut José Wenzel, Adriana Marina Riemens, Ilse De Lange
  • Novel asparaginases and uses thereof
    Publication number: 20120045549
    Abstract: The present invention relates to an asparaginase having the width of the pH activity profile which is at least 3.5. Furthermore the invention relates to newly identified asparaginase polypeptide according to any one of SEQ ID NO: 2 or SEQ ID NO: 4 and to variants thereof and to polynucleotide sequences that encode such novel asparaginase variants. Furthermore the invention relates to the use of these novel asparaginase variants in industrial processes.
    Type: Application
    Filed: August 29, 2011
    Publication date: February 23, 2012
    Inventors: Jan Metske Laan Van Der, Mark Cristiaan Stor, Ilse De Lange, Lisette Mohrmann