Abstract: An optical lens array for imaging and illumination applications is provided. The lens array comprises a first axicon at a first end of the array, a second axicon positioned distally from the first axicon along an optical axis and a third axicon positioned distally from the second axicon along the optical axis. The third axicon provides an objective lens to a focal region or focus region. The third axicon is positioned at a fixed location in the array wherein the distance between the first and second axicons can be altered to control the position of the focal region defined by the depth of field for imaging applications and depth of focus for illumination applications of the third axicon.

Abstract: An optical lens array for imaging and illumination applications is provided. The lens array comprises a first axicon at a first end of the array, a second axicon positioned distally from the first axicon along an optical axis and a third axicon positioned distally from the second axicon along the optical axis. The third axicon provides an objective lens to a focal region or focus region. The third axicon is positioned at a fixed location in the array wherein the distance between the first and second axicons can be altered to control the position of the focal region defined by the depth of field for imaging applications and depth of focus for illumination applications of the third axicon.

Abstract: In accordance with the objects outlined above, the present invention provides methods of diagnosing individuals at risk for a disease state which results in aberrant Rad51 loci. The methods comprise determining the distribution of Rad51 foci in a first tissue type of a first individual, and then comparing the distribution to the distribution of Rad51 foci from a second normal tissue type from the first individual or a second unaffected individual. A difference in the distributions indicates that the first individual is at risk for a disease state which results in aberrant Rad51 loci. Preferred disease states include cancer and disease states associated with apoptosis.

Abstract: In accordance with the objects outlined above, the present invention provides methods of diagnosing individuals at risk for a disease state which results in aberrant Rad51 loci. The methods comprise determining the distribution of Rad51 foci in a first tissue type of a first individual, and then comparing the distribution to the distribution of Rad51 foci from a second normal tissue type from the first individual or a second unaffected individual. A difference in the distributions indicates that the first individual is at risk for a disease state which results in aberrant Rad51 loci. Preferred disease states include cancer and disease states associated with apoptosis.

Abstract: In a wavelength-division multiplexer/demultiplexer of the free-space kind, which uses a diffraction grating or other angularly-dispersive element, spatially-shaping the light beam(s) to modify the passband response in the dispersion plane results in a substantially flat spectral response. Spatial shaping may be obtained using lenses disposed adjacent ports through which pass a corresponding plurality of angularly-dispersed light beams having different centre frequencies/wavelengths. Each lens may be a cylindrical lens with its cylindrical axis normal to the dispersion plane so as to shape the light beam in only one direction, i.e. that of the dispersion plane. The lenses may each be a single lens, conveniently a microlens, each adjacent a port through which WDM light beams pass. Alternatively, a plurality of microlenses may be provided adjacent the plurality of ports and a single microlens adjacent the single WDM port.

Abstract: Compositions and methods are provided for identifying and diagnosing individuals at risk for a disease state associated with aberrant Rad41 foci.

Abstract: An optical circuit has a loop mirror coupled to a 3-dB coupler, with a chirped fiber Bragg grating coupled in the mirror loop. When a beam of light from a broadband light source is launched into the circuit, the circuit functions as a tunable notch filter or as a bandpass filter depending on which output port of the coupler is used to monitor the response. An interference fringe pattern generated in the response of the circuit enables to determine dispersion of the chirped Bragg grating.

Abstract: Compositions and methods are provided for identifying agents which bind to or modulate Rad51.

Abstract: The invention relates to complexes of eukaryotic Rad52 protein and nucleic acids, and methods of using the complexes.