Patents by Inventor Ilya Okun
Ilya Okun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11065251Abstract: Methods are disclosed for treating acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) using compounds that inhibit p21 protein (Cdc42/Rac)-activated kinase (PAK1).Type: GrantFiled: April 3, 2017Date of Patent: July 20, 2021Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINEInventors: Ulrich Steidl, Ashley M. Eckel, Robert F. Stanley, Boris Rogovoy, Ilya Okun
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Publication number: 20200323855Abstract: Methods are disclosed for treating acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) using compounds that inhibit p21 protein (Cdc42/Rac)-activated kinase (PAK1).Type: ApplicationFiled: April 3, 2017Publication date: October 15, 2020Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.Inventors: Ulrich Steidl, Ashley M. Eckel, Robert F. Stanley, Boris Rogovoy, Ilya Okun
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Patent number: 8486936Abstract: Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary diseases and disorders.Type: GrantFiled: May 4, 2010Date of Patent: July 16, 2013Assignee: AllaChem, LLCInventors: Alexander Khvat, Sergey Tkachenko, Ilya Okun, Borys Rogovoy, Nikolay Savchuk, John May, Patrick O'Connor, William Ripka, Jean-Michel Vernier, David Matthews
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Patent number: 8486945Abstract: The invention relates to novel heterocyclic compounds and to the use thereof, to pharmaceutical compositions containing said chemical compounds as an active ingredient and to the use thereof for producing medicinal preparations for the human being and warm-blood animals for treating diseases caused by the aberrant activity of an Hedgehog (Hh)-signal system, in particular oncological diseases. The invention also relates to the use of the above-mentioned compounds in the form of ‘molecular pharmacological tools’ for examining (in vitro and in vivo) the biochemical features of the Hh-signal system, in particular, the interaction of Hh protein and transmembrane proteins, namely, suppressor Patched (Ptc) and protooncogenic proteins.Type: GrantFiled: December 12, 2008Date of Patent: July 16, 2013Inventors: Andrey Ivashchenko, Yan Lavrovsky, Sergey Malyarchuk, Ilya Okun, Nikolay Savchuk, Sergey Tkachenko, Alexander Khvat, Alexander Ivashchenko
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Publication number: 20110098291Abstract: Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary diseases and disorders.Type: ApplicationFiled: May 4, 2010Publication date: April 28, 2011Applicant: Alla Chem Inc.Inventors: Alexander KHVAT, Sergey TKACHENKO, Ilya OKUN, Borys V. ROGOVOY, Nikolay SAVCHUK, John MAY, Patrick O'CONNOR, William RIPKA, Jean-Michel VERNIER, David MATTHEWS
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Publication number: 20090186374Abstract: An apparatus and method for real-time measurement of an effect of different concentrations of a test compound or series of test compounds on living cells, in which a flow of cell suspension is combined with a flow of the test compound and a cellular response of the living cells is repeatedly measured by a detector along a length of a detection zone where the cell suspension-test compound mixture is situated. The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test compounds and generation of three-dimensional dose/response/time profiles within a short timespan.Type: ApplicationFiled: February 21, 2008Publication date: July 23, 2009Applicant: Etogen ScientificInventors: Alex Okun, Gregory Kaler, Ilya Okun
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Publication number: 20030100762Abstract: Compounds of the formula (I) are provided, wherein n is 1 or 2, Q1 and Q2 are each individually selected from the group consisting of O and S, X is H or halogen, and R1, R2, R3 and R4 are each individually selected from the group consisting of hydrogen and uncharged groups having from 1 to about 20 carbon atoms. Methods of making such compounds are also described. Such compounds are useful as fluorescent dyes.Type: ApplicationFiled: August 23, 2002Publication date: May 29, 2003Inventors: Gregory Kaler, Clinton A. Threlfall, Channa Basava, Ilya Okun
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Patent number: 6379917Abstract: An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogenous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose/response profiles within a short timespan.Type: GrantFiled: July 28, 2000Date of Patent: April 30, 2002Assignee: Axiom BiotechnologiesInventors: Ilya Okun, Alex Okun
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Patent number: 6287758Abstract: Sensitive methods for identifying compounds having biological activity comprising combining living cells with two fluorescent membrane permeable ionic dyes having the same charge sign, the first of which has an emission spectrum which overlaps the excitation spectrum of the second fluorescent membrane penetrative dye. The fluorescence is then induced by illuminating the dyes at a wavelength corresponding to the excitation spectrum of the first fluorescent dye and emission is then registered at a wavelength corresponding to the emission spectrum of the second fluorescent dye (FRET). The change in the FRET is indicative of a modulation of cell membrane potential by the biologically active compounds.Type: GrantFiled: March 23, 2000Date of Patent: September 11, 2001Assignee: Axiom Biotechnologies, Inc.Inventors: Ilya Okun, Alex Okun, Gregory Kaler
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Patent number: 6280967Abstract: An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogeneous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose/response profiles within a short time span.Type: GrantFiled: August 5, 1999Date of Patent: August 28, 2001Assignee: Axiom Biotechnologies, Inc.Inventors: John Ransom, Ilya Okun, Alex Okun
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Patent number: 6242209Abstract: An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogeneous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose/response profiles within a short time span.Type: GrantFiled: May 10, 2000Date of Patent: June 5, 2001Assignee: Axiom Biotechnologies, Inc.Inventors: John Ransom, Ilya Okun, Alex Okun
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Patent number: 6096509Abstract: An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogeneous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose/response profiles within a short timespan.Type: GrantFiled: May 24, 1999Date of Patent: August 1, 2000Assignee: Axiom Biotechnologies, Inc.Inventors: Ilya Okun, Alex Okun
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Patent number: 5919646Abstract: An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogeneous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose/response profiles within a short timespan.Type: GrantFiled: August 1, 1997Date of Patent: July 6, 1999Assignee: Axiom Biotechnologies, Inc.Inventors: Ilya Okun, Alex Okun
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Patent number: 5804436Abstract: An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds on a flowing suspension of cells in which a homogeneous suspension of living cells is combined with a concentration of a test compound, directed through a detection zone, and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone. The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose/response profiles within a short timespan.Type: GrantFiled: August 2, 1996Date of Patent: September 8, 1998Assignee: Axiom Biotechnologies, Inc.Inventors: Ilya Okun, Alex Okun