Abstract: A surgical instrument (1) with a grip part (2), which is provided with a working part (26), which has a tool part in an end area and is provided with a slide (57). The slide (57) is adjustable in relation to the working part (26). The adjusting movement (double arrow 18) brings about a working movement of the tool part. The adjusting movement (double arrow 18) can be brought about by an actuating drive (6, 7, 8, 9, 10), which can be activated by an actuating element (38), which can be actuated manually. To attain the strongest possible actuating forces, a control means (35) is provided, which can be controlled via the actuating element (38) and by which the actuating drive (6, 7, 8, 9, 10) arranged in the area of the grip part (2) can be actuated. The actuating drive (6, 7, 8, 9, 10) now brings about the working movement of the slide (57) depending on the position of the actuating element (38) and is mechanically coupled with the slide (57) via a lever mechanism (10).