Abstract: The invention relates to a method for producing high specific activity radionuclides, comprising the steps of: a) irradiating a target of interest by a particle beam, so as to obtain an irradiated target comprising radionuclides of interest, b) chemically extracting a batch of radionuclides of interest from the irradiated target, c) mass-separating the batch of radionuclides of interest so as to obtain high specific activity radionuclides.

Abstract: A neutron activator (10) comprising: a neutron source (11) comprising: a housing (12) extending along a longitudinal axis (B), and a metallic target (20) configured to produce neutrons through the interaction with a proton beam (5), the target (20) comprising at least one plate (21) arranged transversally with respect to the longitudinal axis (B), a cooling circuit configured to cool the metallic target (20), a first reflector-moderator (35) including an activation area (36) configured to accommodate the neutron source (11) and the material to be activated.

Abstract: A neutron activator includes a neutron source and a reflector-moderator. The neutron source has a housing extending along a longitudinal axis (B). A metallic target as part of the neutron source is provided to produce neutrons through the interaction with a proton beam, the metallic target having a plurality of plates arranged transversally with respect to the longitudinal axis (B). The neutron source also includes a cooling circuit to cool the metallic target. The reflector-moderator has an activation area configured to accommodate the neutron source and the material to be activated.

Abstract: A composition of microparticles includes a non-radioactive and a radioactive isotope, and an injection vehicle, for use in the intratumoral treatment of cancer, by combined antitumoral effect of radioactivity and intratumoral microparticle deposition. The antitumoral effect provided by the cytotoxicity of radioactivity is enhanced by a modulation of the tumoral immune response induced by microparticle deposition inside the tumor, thereby decreasing the dose of radioactivity required to treat solid tumors. A method of treating solid tumors using a sub-optimal tumor-volume coverage dose of radioactivity combined with intratumoral microparticle deposition as a mean of tumor control is also disclosed.

Abstract: A neutron activator includes a neutron source and a first reflector-moderator. The neutron source has a housing extending along a longitudinal axis (B). A metallic target as part of the neutron source is provided to produce neutrons through the interaction with a proton beam, the target having at least one plate arranged transversally with respect to the longitudinal axis (B). The neutron source also includes a cooling circuit to cool the metallic target. The first reflector-moderator has an activation area configured to accommodate the neutron source and the material to be activated.