Abstract: Disclosed is a technique for switching from a master node to a secondary node in a communication system. A method of a first communication node may comprise: adding the first communication node as a primary secondary cell (PSCell) to a second communication node through dual connectivity (DC); generating a first user plane path for smart dynamic switching (SDS) and a first instance for supporting the first user plane path according to a request from the second communication node; transmitting information on the first user plane path and the first instance to a terminal; receiving user data based on the first user plane path from the terminal as the first instance; and transmitting the user data to a core network using the first user plane path.

Abstract: Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.

Abstract: The present invention relates to a peptide suppressing the phosphorylation of threonine(T120), the 120th residue of TSPYL5 (testis-specific Y-like protein 5), which is specifically as follows. The present inventors constructed T120D, the mutant of the 120th residue threonine(T120) of TSPYL5, and T120A-TSPYL5 gene and then transfected cells with them in order to investigate the effect of phosphorylation on T120 residue. As a result, wild-type TSPYL5 and T120D moved into nucleus and stayed there. But in the case of T120A-TSPYL5, TSPYL5 did not move into nucleus and instead it was expressed only in cytoplasm. The protein could not bind to AKT, either. Instead, ubiquitination of TSPYL5 was increased but SUMOylation was inhibited. Also, the expressions of ALDH1-A1, -A3, CD44 gene and protein were reduced, and thereby the growth and metastasis of lung cancer cells were suppressed and sphere formation was reduced.

Abstract: The present invention relates to a peptide suppressing the phosphorylation of threonine (T120), the 120th residue of TSPYL5 (testis-specific Y-like protein 5), which is specifically as follows. The present inventors constructed T120D, the mutant of the 120th residue threonine (T120) of TSPYL5, and T120A-TSPYL5 gene and then transfected cells with them in order to investigate the effect of phosphorylation on T120 residue. As a result, wild-type TSPYL5 and T120D moved into nucleus and stayed there. But in the case of T120A-TSPYL5, TSPYL5 did not move into nucleus and instead it was expressed only in cytoplasm. The protein could not bind to AKT, either. Instead, ubiquitination of TSPYL5 was increased but SUMOylation was inhibited. Also, the expressions of ALDH1-A1, -A3, CD44 gene and protein were reduced, and thereby the growth and metastasis of lung cancer cells were suppressed and sphere formation was reduced.

Abstract: The present invention relates to a transgenic plant with enhanced anthocyanin biosynthesis by the introduction of PtrMYB119 gene operably linked to a promoter, a method for preparing the transgenic plant, a method for producing anthocyanin from the transgenic plant, a composition for promoting anthocyanin biosynthesis comprising PtrMYB119 gene operably linked to a promoter, a kit for promoting anthocyanin biosynthesis comprising the composition, and a method for enhancing anthocyanin biosynthesis in a plant comprising introducing the composition into a plant for its expression. The use of the composition for enhancing anthocyanin biosynthesis provided in the present invention enables large-scale production of anthocyanins without any affect on the growth of the plant cell, which is a host, and thus the composition can be widely used for more effective production of anthocyanins.

Abstract: The present invention relates to a transgenic plant with enhanced anthocyanin biosynthesis by the introduction of PtrMYB119 gene operably linked to a promoter, a method for preparing the transgenic plant, a method for producing anthocyanin from the transgenic plant, a composition for promoting anthocyanin biosynthesis comprising PtrMYB119 gene operably linked to a promoter, a kit for promoting anthocyanin biosynthesis comprising the composition, and a method for enhancing anthocyanin biosynthesis in a plant comprising introducing the composition into a plant for its expression. The use of the composition for enhancing anthocyanin biosynthesis provided in the present invention enables large-scale production of anthocyanins without any affect on the growth of the plant cell, which is a host, and thus the composition can be widely used for more effective production of anthocyanins.

Abstract: The present invention relates to a pharmaceutical composition or an anticancer agent for preventing and treating non-small cell lung cancer, containing a substance for regulating the expression or activity of transmembrane 4 L six family member 4 (TM4SF4). More specifically, the present invention relates to a use of a substance for regulating the expression or activity of TM4SF4 as an anticancer drug or an anticancer agent with respect to non-small cell lung cancer, wherein it was ascertained that it is possible to decrease the growth, metastasis, and infiltration of adenocarcinoma cells and radioresistance by decreasing the expression of TM4SF4 in adenocarcinoma among non-small cell lung cancers and to decrease the growth, metastasis, and infiltration of the cells and radioresistance by increasing the expression of TM4SF4 in other non-small cell lung cancers except adenocarcinoma.

Abstract: The present invention relates to a pharmaceutical composition or an anticancer agent for preventing and treating non-small cell lung cancer, containing a substance for regulating the expression or activity of transmembrane 4 L six family member 4 (TM4SF4). More specifically, the present invention relates to a use of a substance for regulating the expression or activity of TM4SF4 as an anticancer drug or an anticancer agent with respect to non-small cell lung cancer, wherein it was ascertained that it is possible to decrease the growth, metastasis, and infiltration of adenocarcinoma cells and radioresistance by decreasing the expression of TM4SF4 in adenocarcinoma among non-small cell lung cancers and to decrease the growth, metastasis, and infiltration of the cells and radioresistance by increasing the expression of TM4SF4 in other non-small cell lung cancers except adenocarcinoma.

Abstract: Disclosed are uses of rare earth element selected from the group consisting of cerium (Ce), praseodymium (Pr), promethium (Pm), europium (Eu), terbium (Tb), dysprosium (Dy), holmium (Ho), erbium (Er), thulium (Tm), ytterbium (Yb), scandium (Sc), yttrium (Y), lanthanum (La), neodymium (Nd), samarium (Sm), gadolinium (Gd), lutetium (Lu) and mixtures thereof, or a salt or an oxide thereof for preventing hair loss, promoting hair regrowth and hair growth, removing and preventing dandruff, or promoting black hair formation.

Abstract: The present invention provides a novel amide derivative of formula (I) and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising same as an active ingredient.

Abstract: Disclosed are uses of rare earth element selected from the group consisting of cerium (Ce), praseodymium (Pr), promethium (Pm), europium (Eu), terbium (Tb), dysprosium (Dy), holmium (Ho), erbium (Er), thulium (Tm), ytterbium (Yb), scandium (Sc), yttrium (Y), lanthanum (La), neodymium (Nd), samarium (Sm), gadolinium (Gd), ruthenium (Lu) and mixtures thereof, or a salt or an oxide thereof for preventing hair loss, promoting hair regrowth and hair growth, removing and preventing dandruff, or promoting black hair formation.

Abstract: The present invention provides a novel amide derivative and a pharmaceutically acceptable salt thereof which selectively and effectively inhibits the growth of cancer cells induced by the overexpression of an epidermal growth factor receptor and also prevents the development of drug resistance caused by the mutation of EGFR tyrosine kinase, and a pharmaceutical composition comprising same as an active ingredient.

Abstract: The invention relates to a transgenic plant or yeast comprising a DNA molecule encoding fungal ATP-binding cassette (ABC) transporter protein, which confers resistance to, and/or accumulation of heavy metals and herbicides. The invention also relates to methods of producing transgenic plants expressing fungal YHL035C protein, which can be used for removing heavy metals and herbicides from polluted soil or water.

Abstract: The present invention relates to novel Pcr family genes that confer tolerance to heavy metals to plants and microorganisms. More particularly, the present invention relates to novel Pcr family genes that confer tolerance to cadmium. The invention also relates to plant and microorganisms transformed with any of the Pcr genes thereby having improved resistance to and increased level of toxic materials, and methods of removing heavy metals from contaminated soil and water contaminated by growing the Pcr-transformed plants on the contaminated soils and water.

Abstract: Disclosed herein is an upright type vacuum cleaner capable of being converted to a canister type. The vacuum cleaner comprises a main body having a suction port and a discharge port, a suction unit having a dust collecting port and a discharge opening, and on which the main body is rotatably installed, a handle installed to the main body, an extension pipe disposed between the handle and the main body and having a hollow inner space to define a flow passage for foreign substances, a securing mechanism between the extension pipe and the main body to restrict a circumference of the extension pipe, a cover installed at a portion of the main body where the securing mechanism and a lower end of the extension pipe are disposed, and an attaching mechanism between the securing mechanism and the cover to allow the extension pipe to be detached from the securing mechanism.

Abstract: Disclosed herein is an angle control apparatus for an upright type vacuum cleaner. The angle control apparatus comprises a main body having a suction port and a discharge port formed thereon and including a suctioning device inside the suction port, a suction unit having a dust collecting port and a discharge opening and on which the main body is rotatably installed, a suction hose made of an elastic material and positioned between the suction port and the discharge opening, and a locking assembly installed to the suction unit to restrict rotation of the main body. With the angle control apparatus, the main body of the vacuum cleaner is rotatably coupled to the suction unit such that the main body is rotated at a suitable angle with respect to the suction unit sliding on a floor according to a location of a user during the cleaning operation, thereby enabling a convenient cleaning operation.

Abstract: Disclosed herein is a main body mounting structure of an upright type vacuum cleaner capable of being converted to a canister type. The mounting structure comprises a main body having a suction port and a discharge port formed thereon and including a suction device inside the suction port, a connection panel on which the main body is detachably installed, a suction unit having a dust collecting port and a discharge opening and on which the connection panel is rotatably installed, an attaching mechanism disposed between the main body and the connection panel, an extension pipe and a handle detachably installed to the main body and having a hollow inner space to define a flow passage along which foreign substances are induced, and a suction hose connected at one end with the suction port and selectively connected at the other end with the discharge opening or the handle.

Abstract: Disclosed herein is a suction hose supporting structure of an upright type vacuum cleaner capable of being converted to a canister type. The vacuum cleaner comprises a main body having a suction port and a discharge port, a suction unit having a dust collecting port and a discharge opening, an extension pipe and a handle detachably installed to the main body, a suction hose connected at one end with the suction port and selectively connected at the other end with the discharge opening or the handle, a bending prevention member installed at one side of the suction port to support the suction hose in a round state, and a fixing ring installed to one side of the suction hose and having a hook. When the vacuum cleaner is used as the upright type, the suction hose is prevented from being bent, thereby minimizing resistance in a flow passage.

Abstract: Disclosed herein is an installation structure of a suction hose for an upright type vacuum cleaner. The installation structure comprises a mounting part provided at either end of the suction hose and formed of a corrugated pipe having a thread shape, a pipe-shaped connecting member secured at one end to one side of the mounting part, an adapter having a securing protrusion formed on an outer surface thereof, and to which the connecting member is latched and secured so as to be restricted in axial movement while being permitted to rotate in a circumferential direction, and a receipt part to which the adapter having the securing protrusion formed thereon is inserted and secured. With this structure, the suction hose has a 360-degree rotation structure so that it is prevented from being twisted during a cleaning operation, thereby ensuring convenient cleaning while providing an appealing appearance.

Abstract: The present invention relates to novel Pcr family genes which confer tolerance to heavy metals to organisms. More particularly, the present invention relates to novel Pcr family genes which confer tolerance to cadmium. Organisms transformed with any of the Pcr genes thereby have improved resistance to and increased level of toxic materials. Soil and water contaminated with heavy metals can be cleaned in an environment-friendly and economical manner by growing the Pcr-transformed organism, especially a plant transformed with the Pcr gene.