Patents by Inventor Imad Ajjawi

Imad Ajjawi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240052001
    Abstract: Disclosed herein are mutant photosynthetic microorgnaisms having an attenuated SGI1 gene. The mutants have reduced chlorophyll and increased productivity with respect to wild type cells. Also disclosed are methods of using such mutants for producing biomass or bioproducts, and methods of screening for such mutants.
    Type: Application
    Filed: September 27, 2023
    Publication date: February 15, 2024
    Inventors: Eric R. Moellering, Nicholas Bauman, Randor R. Radakovits, Roberto Spreafico, Fedor Kuzminov, Imad Ajjawi, Saheed Imam, Andrew Schultz, Kathleen Kwok, Moena Aqui, Jennifer Nominati, John Verruto, Shaun Bailey
  • Patent number: 11787843
    Abstract: Disclosed herein are mutant photosynthetic microorganisms having an attenuated SGI1 gene. The mutants have reduced chlorophyll and increased productivity with respect to wild type cells. Also disclosed are methods of using such mutants for producing biomass or bioproducts, and methods of screening for such mutants.
    Type: Grant
    Filed: February 17, 2021
    Date of Patent: October 17, 2023
    Assignee: Viridos, Inc.
    Inventors: Eric R. Moellering, Nicholas Bauman, Randor R. Radakovits, Roberto Spreafico, Fedor Kuzminov, Imad Ajjawi, Saheed Imam, Andrew Schultz, Kathleen Kwok, Moena Aqui, Jennifer Nominati, John Verruto, Shaun Bailey
  • Patent number: 11332764
    Abstract: The present invention provides mutant microorganism that have higher lipid productivity than the wild type microorganisms from which they are derived while biomass at levels that are within approximately 50% of wild type biomass productivities under nitrogen replete conditions. Particular mutants produce at least twice as much FAME lipid as wild type while producing at least 75% of the biomass produced by wild type cells under nitrogen replete conditions. Also provided are methods of producing lipid using the mutant strains.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: May 17, 2022
    Assignee: Viridos, Inc.
    Inventors: Imad Ajjawi, Eric R. Moellering, Leah Soriaga, Moena Aqui
  • Patent number: 11193132
    Abstract: Mutant photosynthetic organisms having reduced chlorophyll and increased photosynthetic efficiency are provided. The mutant strains have mutated or attenuated: chloroplastic SRP54 gene and SGI1 gene; chloroplastic SRP54 gene and SGI2 gene; chloroplastic SRP54 gene, SGI1, and SGI2 genes are disclosed. The mutant photosynthetic organisms exhibit increased productivity with respect to wild-type strains. Also provided are mutant photosynthetic organisms having mutated or attenuated cytosolic SRP54 genes. Provided herein are methods of producing biomass and other products such as lipids using strains having mutations in an SRP54 gene, SGI1, SGI2 genes, a combination of SGI1/SRP54, and a combination of SGI2 and SRP54 genes. Also included are constructs and methods for attenuating or disrupting SRP54, SGI1, and SGI2 genes.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: December 7, 2021
    Assignee: Synthetic Genomics, Inc.
    Inventors: Imad Ajjawi, Fedor I. Kuzminov, Randor R. Radakovits, John H. Verruto, Sarah Potts, Roberto Spreafico, William F. Lambert, Jessica Greiner
  • Patent number: 11124798
    Abstract: The present invention provides mutant microorganisms having attenuated expression of a gene encoding a polypeptide that includes a TPR domain, wherein the mutant microorganisms have higher lipid productivity and/or exhibit increased partitioning of carbon to lipid as compared to wild type microorganisms from which they are derived. Also provided are methods of producing lipids using the mutant microorganisms, guide RNAs, and nucleic acid constructs used for producing mutant microorganisms.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: September 21, 2021
    Assignee: Synthetic Genomics, Inc.
    Inventors: John Verruto, Eric Moellering, Imad Ajjawi
  • Patent number: 11098328
    Abstract: The present invention provides mutant microorganisms having attenuated expression of a gene encoding a polypeptide that includes a GAF domain wherein the mutant microorganisms have higher lipid productivity and/or exhibit increased partitioning of carbon to lipid as compared to wild-type microorganisms from which they are derived. Also provided are methods of producing lipids using the mutant microorganisms, guide RNAs, and nucleic acid constructs used for producing mutant microorganisms.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: August 24, 2021
    Assignee: Synthetic Genomics, Inc.
    Inventor: Imad Ajjawi
  • Publication number: 20210188924
    Abstract: Disclosed herein are mutant photosynthetic microorganisms having an attenuated SGI1 gene. The mutants have reduced chlorophyll and increased productivity with respect to wild type cells. Also disclosed are methods of using such mutants for producing biomass or bioproducts, and methods of screening for such mutants.
    Type: Application
    Filed: February 17, 2021
    Publication date: June 24, 2021
    Inventors: Eric R. Moellering, Nicholas Bauman, Randor R. Radakovits, Roberto Spreafico, Fedor Kuzminov, Imad Ajjawi, Saheed Imam, Andrew Schultz, Kathleen Kwok, Moena Aqui, Jennifer Nominati, John Verruto, Shaun Bailey
  • Patent number: 10968259
    Abstract: Disclosed herein are mutant photosynthetic microorgnaisms having an attenuated SGI1 gene. The mutants have reduced chlorophyll and increased productivity with respect to wild type cells. Also disclosed are methods of using such mutants for producing biomass or bioproducts, and methods of screening for such mutants.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: April 6, 2021
    Assignee: Synthetic Genomics, Inc.
    Inventors: Eric R. Moellering, Nicholas Bauman, Randor R. Radakovits, Roberto Spreafico, Fedor Kuzminov, Imad Ajjawi, Saheed Imam, Andrew Schultz, Kathleen Kwok, Moena Aqui, Jennifer Nominati, John Verruto, Shaun Bailey
  • Publication number: 20210040515
    Abstract: The present invention provides mutant microorganism that have higher lipid productivity than the wild type microorganisms from which they are derived while biomass at levels that are within approximately 50% of wild type biomass productivities under nitrogen replete conditions. Particular mutants produce at least twice as much FAME lipid as wild type while producing at least 75% of the biomass produced by wild type cells under nitrogen replete conditions. Also provided are methods of producing lipid using the mutant strains.
    Type: Application
    Filed: October 15, 2020
    Publication date: February 11, 2021
    Inventors: Imad Ajjawi, Eric R. Moellering, Leah Soriaga, Moena Aqui
  • Patent number: 10689676
    Abstract: The present invention provides mutant microorganism that have higher lipid productivity than the wild type microorganisms from which they are derived while producing biomass at levels that are at least 45% of wild type biomass productivity under nitrogen replete conditions. Particular mutants produce at least 50% as much FAME lipid as wild type while producing at least the amount of biomass produced by wild type cells under nitrogen replete conditions. Also provided are methods of producing lipid using the mutant strains.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: June 23, 2020
    Assignee: Synthetic Genomics, Inc.
    Inventors: Imad Ajjawi, Leah Soriaga, Moena Aqui, Eric R. Moellering
  • Patent number: 10683514
    Abstract: The application provides recombinant microorganisms with increased productivity with respect to control or wildtype microorganisms. The recombinant microorganisms can include a non-native gene encoding a SKP1 polypeptide or a CHORD-derived polypeptide. Increased productivity can be increased biomass or lipid productivity. These recombinant microorganisms can be used to produce products of interest.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: June 16, 2020
    Assignee: Synthetic Genomics, Inc.
    Inventors: Nicholas Bauman, Imad Ajjawi
  • Publication number: 20200172943
    Abstract: The present invention provides mutant microorganism that have higher lipid productivity than the wild type microorganisms from which they are derived while biomass at levels that are within approximately 50% of wild type biomass productivities under nitrogen replete conditions. Particular mutants produce at least twice as much FAME lipid as wild type while producing at least 75% of the biomass produced by wild type cells under nitrogen replete conditions. Also provided are methods of producing lipid using the mutant strains.
    Type: Application
    Filed: February 13, 2020
    Publication date: June 4, 2020
    Inventors: Imad Ajjawi, Eric R. Moellering, Leah Soriaga, Moena Aqui
  • Patent number: 10563232
    Abstract: The present invention provides mutant microorganism that have higher lipid productivity than the wild type microorganisms from which they are derived while biomass at levels that are within approximately 50% of wild type biomass productivities under nitrogen replete conditions. Particular mutants produce at least twice as much FAME lipid as wild type while producing at least 75% of the biomass produced by wild type cells under nitrogen replete conditions. Also provided are methods of producing lipid using the mutant strains.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: February 18, 2020
    Assignee: Synthetic Genomics, Inc.
    Inventors: Imad Ajjawi, Eric R. Moellering, Leah Soriaga, Moena Aqui
  • Publication number: 20190359919
    Abstract: Provided herein is an effervescent beer containing 0.005-0.17 mg/ml riboflavin such that the beer fluoresces upon exposure to light having an emission spectrum of about 100-500 nm. The riboflavin may be added alone or in combination with one or more additional agents to enhance the flavor, intensity and/or color of the light. Methods of producing such beers are also provided.
    Type: Application
    Filed: February 9, 2018
    Publication date: November 28, 2019
    Inventors: Imad AJJAWI, Joshua M. SHAFFER
  • Publication number: 20190323023
    Abstract: The application provides recombinant microorganisms with increased productivity with respect to control or wildtype microorganisms. The recombinant microorganisms can include a non-native gene encoding a SKP1 polypeptide or a CHORD-derived polypeptide. Increased productivity can be increased biomass or lipid productivity. These recombinant microorganisms can be used to produce products of interest.
    Type: Application
    Filed: July 11, 2019
    Publication date: October 24, 2019
    Inventors: Nicholas Bauman, Imad Ajjawi
  • Publication number: 20190233855
    Abstract: The present invention provides mutant microorganism that have higher lipid productivity than the wild type microorganisms from which they are derived while biomass at levels that are within approximately 50% of wild type biomass productivities under nitrogen replete conditions. Particular mutants produce at least twice as much FAME lipid as wild type while producing at least 75% of the biomass produced by wild type cells under nitrogen replete conditions. Also provided are methods of producing lipid using the mutant strains.
    Type: Application
    Filed: February 5, 2019
    Publication date: August 1, 2019
    Inventors: Imad Ajjawi, Eric R. Moellering, Leah Soriaga, Moena Aqui
  • Patent number: 10351869
    Abstract: The application provides recombinant microorganisms with increased productivity with respect to control or wildtype microorganisms. The recombinant microorganisms can include a non-native gene encoding a SKP1 polypeptide or a CHORD-derived polypeptide. Increased productivity can be increased biomass or lipid productivity. These recombinant microorganisms can be used to produce products of interest.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: July 16, 2019
    Assignee: Synthetic Genomics, Inc.
    Inventors: Nicholas Bauman, Imad Ajjawi
  • Publication number: 20190203221
    Abstract: Mutant photosynthetic organisms having reduced chlorophyll and increased photosynthetic efficiency are provided. The mutant strains have mutated or attenuated: chloroplastic SRP54 gene and SGI1 gene; chloroplastic SRP54 gene and SGI2 gene; chloroplastic SRP54 gene, SGI1, and SGI2 genes are disclosed. The mutant photosynthetic organisms exhibit increased productivity with respect to wild-type strains. Also provided are mutant photosynthetic organisms having mutated or attenuated cytosolic SRP54 genes. Provided herein are methods of producing biomass and other products such as lipids using strains having mutations in an SRP54 gene, SGI1, SGI2 genes, a combination of SGI1/SRP54, and a combination of SGI2 and SRP54 genes. Also included are constructs and methods for attenuating or disrupting SRP54, SGI1, and SGI2 genes.
    Type: Application
    Filed: December 27, 2018
    Publication date: July 4, 2019
    Inventors: Imad Ajjawi, Fedor I. Kuzminov, Randor R. Radakovits, John H. Verruto, Sarah Tacke, Roberto Spreafico, William F. Lambert, Jessica Nichole Greiner
  • Publication number: 20190177738
    Abstract: The present invention provides mutant microorganisms having attenuated expression of a gene encoding a polypeptide that includes a TPR domain, wherein the mutant microorganisms have higher lipid productivity and/or exhibit increased partitioning of carbon to lipid as compared to wild type microorganisms from which they are derived. Also provided are methods of producing lipids using the mutant microorganisms, guide RNAs, and nucleic acid constructs used for producing mutant microorganisms.
    Type: Application
    Filed: December 7, 2018
    Publication date: June 13, 2019
    Inventors: John Verruto, Eric Moellering, Imad Ajjawi
  • Publication number: 20190169627
    Abstract: The present invention provides mutant microorganisms having attenuated expression of a gene encoding a polypeptide that includes a GAF domain wherein the mutant microorganisms have higher lipid productivity and/or exhibit increased partitioning of carbon to lipid as compared to wild-type microorganisms from which they are derived. Also provided are methods of producing lipids using the mutant microorganisms, guide RNAs, and nucleic acid constructs used for producing mutant microorganisms.
    Type: Application
    Filed: December 4, 2018
    Publication date: June 6, 2019
    Inventor: Imad Ajjawi