Patents by Inventor Imad Libbus
Imad Libbus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230106472Abstract: A neurostimulation system comprises a control system configured to monitor a patient receiving neurostimulation therapy. The neurostimulation therapy has a stimulation cycle comprising a stimulation ON period, in which the patient is receiving neurostimulation, and a stimulation OFF period, in which the patient is not receiving neurostimulation. The control system is programmed to receive electrocardiogram (ECG) data from the patient receiving the neurostimulation therapy. The control system is further programmed to monitor a heart rate of the patient based on the ECG data over at least one stimulation cycle of the neurostimulation therapy. The control system is further programmed to generate an indication of signal stability to be displayed to a user based on the received ECG data.Type: ApplicationFiled: October 4, 2021Publication date: April 6, 2023Applicant: LivaNova USA, Inc.Inventors: Imad Libbus, Scott R. Stubbs, Bruce H. KenKnight, Scott Mazar, Badri Amurthur
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Patent number: 11612749Abstract: A method for assessing a patient's suitability for receiving a vagus nerve stimulation therapy includes receiving a criterion regarding the patient's suitability for receiving a vagus nerve stimulation therapy; controlling a stimulation device to provide stimulation to a vagus nerve of the patient; receiving, from a sensor, response data indicative of a physiological response of the patient to the stimulation of the vagus nerve; and determining the patient's suitability for receiving the vagus nerve stimulation therapy based on the criterion and the physiological response of the patient to the stimulation.Type: GrantFiled: March 31, 2017Date of Patent: March 28, 2023Assignee: LivaNova USA, Inc.Inventors: Imad Libbus, Bruce H. Kenknight, Christine Henry
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Patent number: 11554263Abstract: An implantable vagus nerve stimulation (VNS) system includes a sensor configured to measure ECG data for a patient, a stimulation subsystem configured to deliver VNS to the patient, and a control system configured to perform a heart rate variability analysis with the ECG data. In some aspects, performing the heart rate variability analysis includes measuring R-R intervals between successive R-waves for the ECG data measured during a stimulation period and a baseline period, plotting each R-R interval against an immediately preceding R-R interval for each of the stimulation period and the baseline period, and determining at least one of a standard deviation from an axis of a line perpendicular to an identity line for each of the stimulation period plot and the baseline period plot or a centroid of each of the stimulation period plot and the baseline period plot.Type: GrantFiled: May 24, 2019Date of Patent: January 17, 2023Assignee: LivaNova USA, Inc.Inventors: Imad Libbus, Bruce D. Nearing, Badri Amurthur, Bruce H. KenKnight, Richard L. Verrier
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Publication number: 20220296904Abstract: Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.Type: ApplicationFiled: June 8, 2022Publication date: September 22, 2022Inventors: Imad Libbus, Andrew P. Kramer, William J. Linder, Jeffrey E. Stahmann
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Publication number: 20220226657Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.Type: ApplicationFiled: April 8, 2022Publication date: July 21, 2022Applicants: LivaNova USA, Inc., East Tennessee State UniversityInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
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Publication number: 20220203095Abstract: A neurostimulation system comprises a sensor and a control system. The sensor is configured to detect a cardiac physiological measure of a patient. The control system is programmed to monitor, via the sensor, the cardiac physiological measure during the treatment. The control system is further programmed to detect a change in the cardiac physiological measure during the treatment. The control system is further programmed to determine, based on the detected change in the cardiac physiological measure, a first transition time in a duty cycle of a neurostimulation signal delivered to the patient where the neurostimulation signal transitions between a stimulation OFF period and a stimulation ON period.Type: ApplicationFiled: December 29, 2020Publication date: June 30, 2022Inventors: Imad Libbus, Bruce KenKnight, Scott Stubbs, Scott Mazar
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Patent number: 11369794Abstract: Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.Type: GrantFiled: October 9, 2019Date of Patent: June 28, 2022Assignee: Cardiac Pacemakers, Inc.Inventors: Imad Libbus, Andrew P. Kramer, William J. Linder, Jeffrey E. Stahmann
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Publication number: 20220118250Abstract: A method for managing bradycardia through vagus nerve stimulation is provided. An implantable neurostimulator configured to deliver electrical therapeutic stimulation in both afferent and efferent directions of a patient's cervical vagus nerve is provided. An operating mode is stored, which includes parametrically defining a maintenance dose of the electrical therapeutic stimulation tuned to restore cardiac autonomic balance through continuously-cycling, intermittent and periodic electrical pulses. The maintenance dose is delivered via a pulse generator through a pair of helical electrodes via an electrically coupled nerve stimulation therapy lead independent of cardiac cycle. The patient's physiology is monitored, and upon sensing a condition indicative of bradycardia, the delivery of the maintenance dose is suspended.Type: ApplicationFiled: September 27, 2021Publication date: April 21, 2022Applicant: LivaNova USA, Inc.Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight
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Patent number: 11298543Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.Type: GrantFiled: December 27, 2018Date of Patent: April 12, 2022Assignees: LivaNova USA, Inc., East Tennessee State UniversityInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
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Publication number: 20220105347Abstract: A method of neurostimulation titration. The method includes setting titration parameters for an electrical signal delivered by an implantable medical device, initiating titration with the titration parameters and an aggressiveness profile, performing titration by increasing at least one of a current amplitude, a frequency, a pulse width or a duty cycle of the electrical signal until a threshold is reached or a side effect is detected, pausing the titration while waiting for commands from the patient or caregiver, and resuming the titration in response to receiving authorization from an external device.Type: ApplicationFiled: October 15, 2021Publication date: April 7, 2022Applicant: LivaNova USA, Inc.Inventors: Scott Stubbs, Imad Libbus, Scott Mazar, Bruce H. KenKnight, Badri Amurthur
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Publication number: 20220080207Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A titration process is used to gradually increase the stimulation intensity to a desired therapeutic level. This titration process can minimize the amount of time required to complete titration so as to begin delivery of the stimulation at therapeutically desirable levels.Type: ApplicationFiled: November 29, 2021Publication date: March 17, 2022Applicant: LivaNova USA, Inc.Inventors: Imad Libbus, Bruce H. KenKnight, Badri Amurthur
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Publication number: 20220062641Abstract: Systems and methods for customizable titration of an implantable neurostimulator are provided. A method of titrating a neurostimulation signal delivered to a patient from an implantable pulse generator includes delivering a first neurostimulation signal with a first set of parameters, increasing a first value of the first neurostimulation signal at a first rate for a first period of time while delivering the first neurostimulation signal, ceasing delivery of the first neurostimulation signal when the first value reaches a first target value, delivering a second neurostimulation signal with a second set of parameters, and increasing the second neurostimulation signal at a second rate for a second period of time while delivering the second neurostimulation signal.Type: ApplicationFiled: November 8, 2021Publication date: March 3, 2022Applicant: LivaNova USA, Inc.Inventors: Scott Stubbs, Imad Libbus, Scott Mazar, Bruce KenKnight, Badri Amurthur
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Publication number: 20220023637Abstract: According to an embodiment of a method for providing neural stimulation, activity is sensed, and neural stimulation is automatically controlled based on the sensed activity. An embodiment determines periods of rest and periods of exercise using the sensed activity, and applies neural stimulation during rest and withdrawing neural stimulation during exercise. Other embodiments are provided herein.Type: ApplicationFiled: October 12, 2021Publication date: January 27, 2022Inventors: Imad Libbus, Andrew P. Kramer
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Publication number: 20220016428Abstract: An implantable neurostimulator-implemented method for managing tachyarrhythmias through vagus nerve stimulation is provided. An implantable neurostimulator, including a pulse generator, is configured to deliver electrical therapeutic stimulation in a manner that results in creation and propagation (in both afferent and efferent directions) of action potentials within neuronal fibers of a patient's cervical vagus nerve. Operating modes of the pulse generator are stored. A maintenance dose of the electrical therapeutic stimulation is delivered to the vagus nerve via the pulse generator to restore cardiac autonomic balance through continuously-cycling, intermittent and periodic electrical pulses. A restorative dose of the electrical therapeutic stimulation is delivered to prevent initiation of or disrupt tachyarrhythmia through periodic electrical pulses delivered at higher intensity than the maintenance dose.Type: ApplicationFiled: July 29, 2021Publication date: January 20, 2022Applicant: LivaNova USA, Inc.Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight
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Publication number: 20220016429Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.Type: ApplicationFiled: July 30, 2021Publication date: January 20, 2022Applicants: LivaNova USA, Inc., EAST TENNESSEE STATE UNIVERSITYInventors: Bruce H. KenKnight, Jeffrey L. Ardell, Imad Libbus, Badri Amurthur
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Patent number: 11185698Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A titration process is used to gradually increase the stimulation intensity to a desired therapeutic level. This titration process can minimize the amount of time required to complete titration so as to begin delivery of the stimulation at therapeutically desirable levels.Type: GrantFiled: March 1, 2019Date of Patent: November 30, 2021Assignee: LivaNova USA, Inc.Inventors: Imad Libbus, Bruce H. KenKnight, Badri Amurthur
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Patent number: 11167142Abstract: Systems and methods for customizable titration of an implantable neurostimulator are provided. A method of titrating a neurostimulation signal delivered to a patient from an implantable pulse generator includes delivering a first neurostimulation signal with a first set of parameters, increasing a first value of the first neurostimulation signal at a first rate for a first period of time while delivering the first neurostimulation signal, ceasing delivery of the first neurostimulation signal when the first value reaches a first target value, delivering a second neurostimulation signal with a second set of parameters, and increasing the second neurostimulation signal at a second rate for a second period of time while delivering the second neurostimulation signal.Type: GrantFiled: September 13, 2018Date of Patent: November 9, 2021Assignee: LivaNova USA, Inc.Inventors: Scott Stubbs, Imad Libbus, Scott Mazar, Bruce KenKnight, Badri Amurthur
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Patent number: 11154716Abstract: According to an embodiment of a method for providing neural stimulation, activity is sensed, and neural stimulation is automatically controlled based on the sensed activity. An embodiment determines periods of rest and periods of exercise using the sensed activity, and applies neural stimulation during rest and withdrawing neural stimulation during exercise. Other embodiments are provided herein.Type: GrantFiled: June 19, 2019Date of Patent: October 26, 2021Assignee: Cardiac Pacemakers, Inc.Inventors: Imad Libbus, Andrew P. Kramer
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Patent number: 11147972Abstract: A method of neurostimulation titration. The method includes setting titration parameters for an electrical signal delivered by an implantable medical device, initiating titration with the titration parameters and an aggressiveness profile, performing titration by increasing at least one of a current amplitude, a frequency, a pulse width or a duty cycle of the electrical signal until a threshold is reached or a side effect is detected, pausing the titration while waiting for commands from the patient or caregiver, and resuming the titration in response to receiving authorization from an external device.Type: GrantFiled: November 9, 2018Date of Patent: October 19, 2021Assignee: LivaNova USA, Inc.Inventors: Scott Stubbs, Imad Libbus, Scott Mazar, Bruce H. KenKnight, Badri Amurthur
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Patent number: 11129992Abstract: A method for managing bradycardia through vagus nerve stimulation is provided. An implantable neurostimulator configured to deliver electrical therapeutic stimulation in both afferent and efferent directions of a patient's cervical vagus nerve is provided. An operating mode is stored, which includes parametrically defining a maintenance dose of the electrical therapeutic stimulation tuned to restore cardiac autonomic balance through continuously-cycling, intermittent and periodic electrical pulses. The maintenance dose is delivered via a pulse generator through a pair of helical electrodes via an electrically coupled nerve stimulation therapy lead independent of cardiac cycle. The patient's physiology is monitored, and upon sensing a condition indicative of bradycardia, the delivery of the maintenance dose is suspended.Type: GrantFiled: March 15, 2018Date of Patent: September 28, 2021Assignee: LivaNova USA, Inc.Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight