Abstract: This disclosure relates to using stereo-thermo-lesioning (STL) to create lesions at one or more locations in the patient's nervous system at the patient's bedside without general anesthesia. A method that uses STL to treat a patient's neurological condition includes: using a plurality of stereotactically-implanted thermo-coupled multi-contact electrodes to record conduction data within a predetermined theoretical zone of activity within the patient's neurological tissue; detecting abnormal neurological activity of a neurological condition within the conduction data and localize a portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity; creating a lesion at the portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity using at least one contact of the plurality of thermo-coupled multi-contact electrodes.

Abstract: This disclosure relates to forming a lesion in a patient's neurological tissue without requiring general anesthesia. The lesion can be either temporary or permanent. In either case, the lesion can be created by a steerable probe that includes a steerable guide, a laser device, and at least one electrode. The steerable guide steers the probe to a target location in the subject's neurological tissue. When the probe reaches the target location, the laser can create the lesion. The at least one electrode can detect a progressive vanishing of neural activity from the portion of the neurological tissue due to the lesion.

Abstract: Systems and methods for configuring a stereo-electroencephalography to target specific brain regions that are part of large scale neural networks responsible for neurological disorders are described. A hypothesis related to a large scale neural network responsible for a neurological disorder within patient's brain can be received. Coordinates for implantation of at least two depth electrodes in the patient's brain can be determined based on the hypothesis. Electrodes to be implanted can be selected for each of the coordinates. The electrodes can be designed and used to target these specific brain regions, including an insula electrode, a parietal-frontal electrode, a hippocampo electrode, and a perisylvian electrode. A visualization that includes the coordinates and the selected electrodes can be displayed, so that a surgeon can implant the selected electrodes into the patient's brain according to the coordinates to test the hypothesis.

Abstract: This disclosure relates to forming a lesion in a patient's neurological tissue without requiring general anesthesia. The lesion can be either temporary or permanent. In either case, the lesion can be created by a steerable probe that includes a steerable guide, a laser device, and at least one electrode. The steerable guide steers the probe to a target location in the subject's neurological tissue. When the probe reaches the target location, the laser can create the lesion. The at least one electrode can detect a progressive vanishing of neural activity from the portion of the neurological tissue due to the lesion.

Abstract: This disclosure relates to using stereo-thermo-lesioning (STL) to create lesions at one or more locations in the patient's nervous system at the patient's bedside without general anesthesia. A method that uses STL to treat a patient's neurological condition includes: using a plurality of stereotactically-implanted thermo-coupled multi-contact electrodes to record conduction data within a predetermined theoretical zone of activity within the patient's neurological tissue; detecting abnormal neurological activity of a neurological condition within the conduction data and localize a portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity; creating a lesion at the portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity using at least one contact of the plurality of thermo-coupled multi-contact electrodes.

Abstract: The present disclosure relates generally to automating the task of assignment of labels to identify electrical elements (e.g., electrode contacts, electrodes including a plurality of electrode contacts, and/or non-addressable electrical elements, like wires). A system that can automate the task of assignment of labels can include an electrical element, a microelectronic circuit associated with the electrical element, and an acquisition system. The microelectronic circuit can transmit a sequence comprising a label corresponding to the electrical element. The acquisition system can assign the label corresponding to the electrical element to a recording channel after decoding the sequence.

Abstract: The present disclosure relates generally to automating the task of assignment of labels to identify electrical elements (e.g., electrode contacts, electrodes including a plurality of electrode contacts, and/or non-addressable electrical elements, like wires). A system that can automate the task of assignment of labels can include an electrical element, a microelectronic circuit associated with the electrical element, and an acquisition system. The microelectronic circuit can transmit a sequence comprising a label corresponding to the electrical element. The acquisition system can assign the label corresponding to the electrical element to a recording channel after decoding the sequence.

Abstract: The present invention relates electrical stimulation of structures having high fiber density, such as white matter tracts of the brain, to effect desired stimulation of associated brain structures. The stimulation of such white matter tracts or other structures can help reduce seizures or otherwise help control seizures by overdriving at least some electrical activity of the associated brain structures.

Abstract: The present invention relates to providing a stimulus to brain structures having high fiber density, such as white matter tracts. The stimulus, which can be electrical, pharmacological and/or genetic, is operative to employ the white matter to affect associated brain structures associated with the white matter to help induce a desired physiological response, such as helping to reduce or control seizures.