Patents by Inventor Iman Daryaei

Iman Daryaei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF DETECTING AND TREATING THROMBOSIS AND VASCULAR PLAQUES
    Publication number: 20240148914
    Abstract: The invention provides nanodroplets labeled with targeting ligands that are useful in the detection and treatment of vascular thromboses (e.g., fibrin clots) and vascular plaques, or related diseases and conditions, as well as methods of preparation and use thereof.
    Type: Application
    Filed: July 8, 2023
    Publication date: May 9, 2024
    Inventors: Evan C. Unger, Emmanuelle Joelle Meuillet, Iman Daryaei, Maria Fernanda Acosta
  • METHOD OF SYNTHESIZING 18F RADIOLABELED BIOMOLECULAR AGENTS
    Publication number: 20230310663
    Abstract: Methods of preparing 18F targeting biomolecules and small molecules with biological activity for therapeutic and/or diagnostic applications using fluorinated aromatic compounds. A fluorinated conjugated target tracer is synthesized and purified with temperature and solvent conditions that are mild for the tracer molecule. The purified fluorinated-conjugated target tracer is then labeled with 18F using 18F salts within a short reaction time, and with temperature and solvent conditions that are mild for the tracer molecule. The method provides a quick and convenient process that maintains the biological activities of the target molecules. The radio-labeled biomolecules may be used as contrast agents for Positron Emission Tomography (PET).
    Type: Application
    Filed: April 17, 2023
    Publication date: October 5, 2023
    Inventors: Iman Daryaei, Houng Dang, Nathan Wright, Julian Dresler
  • Method of synthesizing F radiolabeled biomolecular agents
    Patent number: 11628229
    Abstract: A method for preparing 18F radiolabeled biomolecules and agents for 18F-PET imaging is disclosed herein. A perfluoroaryl-conjugated target tracer is synthesized and purified with temperature and solvent conditions that are mild for the tracer molecule. The purified perfluoroaryl-conjugated target tracer is then labeled with 18F using 18F salts within a short reaction time, and with temperature and solvent conditions that are mild for the tracer molecule. The method provides a quick and convenient process that maintains the biological activities of the target molecules. The radio-labeled biomolecules may be used as contrast agents for Positron Emission Tomography (PET).
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: April 18, 2023
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Mark D. Pagel, Iman Daryaei, Abigail Shepard
  • COMPOSITIONS AND METHODS OF DETECTING AND TREATING THROMBOSIS AND VASCULAR PLAQUES
    Publication number: 20220305143
    Abstract: The invention provides nanodroplets labeled with targeting ligands that are useful in the detection and treatment of vascular thromboses (e.g., fibrin clots) and vascular plaques, or related diseases and conditions, as well as methods of preparation and use thereof.
    Type: Application
    Filed: June 1, 2020
    Publication date: September 29, 2022
    Inventors: Evan C. Unger, Emmanuelle Joelle Meuillet, Iman Daryaei, Maria Fernanda Acosta
  • COMPOSITIONS AND METHODS OF DETECTING AND TREATING ALZHEIMER'S DISEASE
    Publication number: 20210008204
    Abstract: The invention provides microbubbles and/or nanodroplets labeled with diagnostic and/or therapeutic ligands that are useful in the detection and treatment of Alzheimer's disease, or related diseases and conditions, as well as methods of preparation and use thereof.
    Type: Application
    Filed: March 28, 2019
    Publication date: January 14, 2021
    Inventors: Evan C. Unger, Iman Daryaei, Emmanuelle Joelle Meuillet
  • METHOD OF SYNTHESIZING 18F RADIOLABELED BIOMOLECULAR AGENTS
    Publication number: 20200009274
    Abstract: A method for preparing 18F radiolabeled biomolecules and agents for 18F-PET imaging is disclosed herein. A perfluoroaryl-conjugated target tracer is synthesized and purified with temperature and solvent conditions that are mild for the tracer molecule. The purified perfluoroaryl-conjugated target tracer is then labeled with 18F using 18F salts within a short reaction time, and with temperature and solvent conditions that are mild for the tracer molecule. The method provides a quick and convenient process that maintains the biological activities of the target molecules. The radio-labeled biomolecules may be used as contrast agents for Positron Emission Tomography (PET).
    Type: Application
    Filed: March 13, 2018
    Publication date: January 9, 2020
    Inventors: Mark D. Pagel, Iman Daryaei, Abigail Shepard