Patents by Inventor Imelda Lam

Imelda Lam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RAS protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
    Patent number: 12630547
    Abstract: Provided herein are RAS protein degraders, e.g., a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a RAS-mediated disorder, disease, or condition.
    Type: Grant
    Filed: September 14, 2020
    Date of Patent: May 19, 2026
    Assignee: BioTheryX, Inc.
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, David Aaron Hecht, Imelda Lam, Frank Mercurio, Robert W. Sullivan, Eduardo Torres
  • ESTROGEN RECEPTOR DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20240368121
    Abstract: Provided herein are estrogen receptor degraders, for example, a compound of Formula (I), RT-L-RE; and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms r of an estrogen receptor-mediated disorder, disease, or condition.
    Type: Application
    Filed: August 16, 2022
    Publication date: November 7, 2024
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, Imelda Lam, Patrick Papa, Angela Schoolmeesters, Eduardo Torres
  • SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20240197888
    Abstract: Provided herein are SOS1 protein degraders, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a SOS1-mediated disorder, disease, or condition.
    Type: Application
    Filed: March 16, 2022
    Publication date: June 20, 2024
    Inventors: Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, Imelda Lam, Patrick Papa, Navin Rajapakse, Angela Schoolmeesters, Eduardo Torres
  • KRAS PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20240190885
    Abstract: Provided herein are KRAS protein degraders, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a KRAS-mediated disorder, disease, or condition.
    Type: Application
    Filed: March 30, 2022
    Publication date: June 13, 2024
    Inventors: Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, Imelda Lam, Patrick Papa, Navin Rajapakse, Angela Schoolmeesters, Eduardo Torres
  • KRAS PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20240190883
    Abstract: Provided herein are KRAS protein degraders, for example, a compound of Formula (A), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a KRAS-mediated disorder, disease, or condition.
    Type: Application
    Filed: December 16, 2023
    Publication date: June 13, 2024
    Applicant: BioTheryX, Inc.
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, David Aaron Hecht, Imelda Lam, Patrick Papa, Angela Schoolmeesters, Eduardo Torres
  • SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20240174643
    Abstract: Provided herein are SOS1 protein degraders, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of an SOS1-mediated disorder, disease, or condition.
    Type: Application
    Filed: December 16, 2023
    Publication date: May 30, 2024
    Applicant: BioTheryX, Inc.
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, David Aaron Hecht, Imelda Lam, Patrick Papa, Angela Schoolmeesters, Eduardo Torres
  • SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20240025863
    Abstract: Provided herein are SOS1 protein degraders, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of an SOS1-mediated disorder, disease, or condition.
    Type: Application
    Filed: September 16, 2021
    Publication date: January 25, 2024
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, David Aaron Hecht, Imelda Lam, Patrick Papa, Angela Schoolmeesters, Eduardo Torres
  • BIARYLSULFONAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE FOR TREATING FIBROTIC LUNG DISEASE
    Publication number: 20230201144
    Abstract: Provided herein are a biarylsulfonamide, e.g., a compound of Formula (IA), and a pharmaceutical composition thereof. Also provided herein is a method of treating a fibrotic lung disease with a biarylsulfonamide, alone or in combination with an antifibrotic agent. Additionally, provided herein is a method of slowing the rate of decline in pulmonary function in a subject having a fibrotic lung disease with a biarylsulfonamide, alone or in combination with an antifibrotic agent.
    Type: Application
    Filed: May 31, 2021
    Publication date: June 29, 2023
    Applicant: NovoMedix, LLC
    Inventors: Cathy A. Swindlehurst, Kyle W.H. Chan, Laura Graciana Corral, Paul E. Erdman, Leah M. Fung, Imelda Lam, Robert W. Sullivan, Eduardo Torres
  • RAS PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20230002371
    Abstract: Provided herein are RAS protein degraders, e.g., a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a RAS-mediated disorder, disease, or condition.
    Type: Application
    Filed: September 14, 2020
    Publication date: January 5, 2023
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, David Aaron Hecht, Imelda Lam, Frank Mercurio, Robert W. Sullivan, Eduardo Torres
  • PROTEIN-TARGETING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20220298172
    Abstract: The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided.
    Type: Application
    Filed: May 30, 2022
    Publication date: September 22, 2022
    Applicant: BioTheryX, Inc.
    Inventors: Kyle W.H. Chan, Paul E. Erdman, Aparajita Hoskote Chourasia, Leah M. Fung, David Aaron Hecht, Imelda Lam, Frank Mercurio, Robert W. Sullivan, Eduardo Torres
  • Substituted isoindolinones
    Patent number: 11352338
    Abstract: Substituted isoindolinones of Formula (I), methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat or ameliorate diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: June 7, 2022
    Assignee: BioTheryX, Inc.
    Inventors: Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, Imelda Lam, Frank Mercurio, Robert W. Sullivan, Eduardo Torres
  • Protein-targeting compounds and pharmaceutical compositions thereof, and their therapeutic applications
    Patent number: 11345712
    Abstract: The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: May 31, 2022
    Assignee: BioTheryX, Inc.
    Inventors: Kyle W. H. Chan, Paul E. Erdman, Leah Fung, David Aaron Hecht, Imelda Lam, Robert Sullivan, Eduardo Torres
  • PROTEIN-TARGETING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20200369679
    Abstract: The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided.
    Type: Application
    Filed: May 26, 2020
    Publication date: November 26, 2020
    Inventors: Kyle W.H. Chan, Paul E. Erdman, Aparajita Hoskote Chourasia, Leah Fung, David Aaron Hecht, Imelda Lam, Frank Mercurio, Robert Sullivan, Eduardo Torres
  • Substituted isoindolinones
    Patent number: 10844039
    Abstract: Substituted isoindolinones of Formula (I), methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat or ameliorate diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: November 24, 2020
    Assignee: BioTheryX, Inc.
    Inventors: Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, Imelda Lam, Frank Mercurio, Robert Sullivan, Eduardo Torres
  • SUBSTITUTED ISOINDOLINONES
    Publication number: 20200325114
    Abstract: Substituted isoindolinones of Formula (I), methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat or ameliorate diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.
    Type: Application
    Filed: June 25, 2020
    Publication date: October 15, 2020
    Applicant: BioTheryX, Inc.
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, Imelda Lam, Frank Mercurio, Robert W. Sullivan, Eduardo Torres
  • SUBSTITUTED ISOINDOLINONES
    Publication number: 20200148663
    Abstract: Substituted isoindolinones of Formula (I), methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat or ameliorate diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.
    Type: Application
    Filed: November 12, 2019
    Publication date: May 14, 2020
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, Imelda Lam, Frank Mercurio, Robert Sullivan, Eduardo Torres
  • Thienopyrimidinone compounds
    Patent number: 10584133
    Abstract: The present disclosure provides compounds that modulate protein function and/or restore protein homeostasis. The disclosure provides methods of modulating protein-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other therapeutic agents, are provided.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: March 10, 2020
    Assignee: BioTheryX, Inc.
    Inventors: Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, Imelda Lam, Frank Mercurio, Robert Sullivan, Eduardo Torres
  • THIENOPYRIMIDINONE COMPOUNDS
    Publication number: 20190322682
    Abstract: The present disclosure provides compounds that modulate protein function and/or restore protein homeostasis. The disclosure provides methods of modulating protein-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other therapeutic agents, are provided.
    Type: Application
    Filed: March 28, 2019
    Publication date: October 24, 2019
    Inventors: Kyle W.H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, Imelda Lam, Frank Mercurio, Robert Sullivan, Eduardo Torres