Abstract: The present invention relates to the dosing regiment for anti-CD20 antibody to treat various diseases.

Abstract: A method of treating, arresting or preventing a disease responsive to treatment with an anti-CD20 antibody in a patient suffering therefrom, comprising administering to the patient at least one sub-depleting dose of antiCD20 antibody is disclosed.

Abstract: A system for forecasting outcomes of clinical trials including a digital computer having a central processor, a programmable graphical or programmable analog coprocessor in communication with the central processor, interface software in communication with the central processor and coprocessor, modeling software having simulation capability substantially executed by the central processor and in communication with the interface software, integration software substantially executed by the central processor in communication with the modeling software, partial derivative software substantially executed by the coprocessor and in communication with the interface software, a historical clinical trial data component, a model data component specifying the time course of a clinical observation by a differential equation, and a protocol data component specifying the characteristics of a population intended to undergo a future clinical trial, all the said data components in communication with the modeling software.