Abstract: The present invention provides a formulation of Ginsenoside Rg3-loaded niosomes enhance its pharmacokinetic properties and improve its anticancer efficacy, both in vitro and in silico, by facilitating targeted delivery and interaction with key cancer-related molecules such as Cathepsin B. The present invention provides a method for synthesizing Ginsenoside Rg3-loaded nanoniosomes, comprising dissolving cholesterol and Span 80 in chloroform to form a lipid phase; dissolving Ginsenoside Rg3 in methanol and transferring the dissolved Ginsenoside Rg3 into the lipid phase; evaporating the chloroform and methanol solvent mixture at a temperature of 40° C. to form a thin lipid film; hydrating the thin lipid film using phosphate-buffered saline (PBS) for 25 minutes at 45° C. to form the nanoniosomal formulation; cooling the formulation overnight; and subjecting the formulation to sonication for 40 minutes to reduce the mean vesicle size.

Abstract: Managing data in a computing device is disclosed, including generating reverse delta updates during an apply operation of a forward delta update. A method includes operations of applying forward update data to an original data object to generate an updated data object from the original data object and generating, during the applying, reverse update data, the reverse update data configured to reverse effects of the forward update data and restore the original data object from the updated data object.

Abstract: Managing data in a computing device is disclosed, including generating reverse delta updates during an apply operation of a forward delta update. A method includes operations of applying forward update data to an original data object to generate an updated data object from the original data object and generating, during the applying, reverse update data, the reverse update data configured to reverse effects of the forward update data and restore the original data object from the updated data object.

Abstract: A menu selection technique (300) dynamically updates a display of a portable communication device, such as a two-way radio. The user enters an alphanumeric entry (306) via a keypad, each entry being added to the contents of an input buffer (308) of the portable communication device. The content of the buffer is matched with available features (310) and the display is updated with a menu selection of the matched available features (312). As user entries are progressively entered, the selection of menu features narrows until the user selects a feature (314) and the feature is launched (316).