Patents by Inventor Imran Kazmi

Imran Kazmi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250186347
    Abstract: A process enables efficient preparation of liposome-encapsulated peptide P33. The process comprising preparing a peptide P33; preparing a lipid mixture by dissolving 70-90 mg of phospholipid including granulated soy lecithin and 20 mg of cholesterol in 15-25 mg of a chloroform/methanol solvent system; evaporating organic solvent using a magnetic stirrer coupled with a heating system until a lipid film is fully formed and hydrated; removing solvent traces by drying the lipid film under vacuum conditions overnight; rehydrating the lipid film with 8-12 mL of a buffer containing 190-210 ?g/mL of peptide P33; mixing the rehydrated lipid film thoroughly using a magnetic stirrer at ambient temperature to ensure uniform dispersion; sonicating the lipid suspension until a clear, translucent solution is obtained; and extruding the resulting suspension using a vortex to form large unilamellar vesicles (LUVs) with a uniform size of approximately 200 nm.
    Type: Application
    Filed: February 18, 2025
    Publication date: June 12, 2025
    Inventors: Hisham N ALTAYB, Mohammed ALZAIN, Karem IBRAHEM, Bandar Hasan SALEH, Abdulaziz ALSAEDI, Ehssan MOGLAD, Ahmad M SAIT, Mohammed MUFRRIH, Hussam DAGHISTANI, Waiel S. HALABI, Abdelbagi ALFADIL, Mazin ZAMZAMI, Imran KAZMI
  • Publication number: 20250041236
    Abstract: The present invention provides a formulation of Ginsenoside Rg3-loaded niosomes enhance its pharmacokinetic properties and improve its anticancer efficacy, both in vitro and in silico, by facilitating targeted delivery and interaction with key cancer-related molecules such as Cathepsin B. The present invention provides a method for synthesizing Ginsenoside Rg3-loaded nanoniosomes, comprising dissolving cholesterol and Span 80 in chloroform to form a lipid phase; dissolving Ginsenoside Rg3 in methanol and transferring the dissolved Ginsenoside Rg3 into the lipid phase; evaporating the chloroform and methanol solvent mixture at a temperature of 40° C. to form a thin lipid film; hydrating the thin lipid film using phosphate-buffered saline (PBS) for 25 minutes at 45° C. to form the nanoniosomal formulation; cooling the formulation overnight; and subjecting the formulation to sonication for 40 minutes to reduce the mean vesicle size.
    Type: Application
    Filed: October 22, 2024
    Publication date: February 6, 2025
    Inventors: Auwal Ibrahim TANKO, Salman HOSAWI, Syed Sarim IMAM, Misbahuddin RAFEEQ, Alaa Hamed HABIB, Muhammad Barkaat HUSSAIN, Mukhtiar BAIG, Imran KAZMI
  • Publication number: 20230330068
    Abstract: The present invention generally relates to a process for manufacturing gel composition of Luliconazole for treatment of vaginal fungal infections cooling 50% quantity of purified water at 4° C.; adding 0.10-0.30% of Carbopol 934, 5-15% of poloxamer 188 and 15-25% of poloxamer 407 slowly under constant stirring and placing at 4° C., until a clear solution is obtained; adding 0.1-0.5% HPMC K100M gradually under stirring and leaving for 24 hours at room temperature; adding 0.5-2% Luliconazole solution slowly under high speed homogenizer; adding 0-0.5% Sodium methyl parabens and 0-1% Sodium propyl parabens solution under constant stirring; adding 0.1-0.5% sodium chloride under stirring; checking and maintaining pH of the obtained solution; and preparing the obtained solution volume to 100% with purified water and stirring for 30 min for manufacturing gel composition of Luliconazole.
    Type: Application
    Filed: April 26, 2023
    Publication date: October 19, 2023
    Inventors: Fahad A. Al-Abbasi, Shareefa A. AlGhamdi, Salman Bakr Hosawi, Amira M. Alghamdi, Mustafa Zeyadi, Mujaddad Ur Rehman, Govind Vyas, Imran Kazmi
  • Publication number: 20230277473
    Abstract: The present invention generally relates to a process for preparing polymeric-based nanoparticle of RPD coated with Tf and RVG comprises dissolving 1-12 wt % of RPD and 8-96 wt % of lipid in isopropyl alcohol (IPA) and heating the solution to 70° C. to create the organic phase; adding prepared organic solution to the 0-2 wt % of aqueous surfactant solution using a syringe at 70° C. temperature; swirling the obtained solution at 1000 rpm on a high speed homogenizer for 15 minutes after the solvent is evaporated using a magnetic stirrer to create the SLNs dispersion; and adding 45-100 wt % of Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and 45-100 wt % of N-Hydroxysulfosuccinimide (NHS), which included activating the carboxylic acid terminal groups and conjugating Tf and RVG to RPD's PLGA nanoparticles.
    Type: Application
    Filed: April 26, 2023
    Publication date: September 7, 2023
    Inventors: Fahad A. Al-Abbasi, Shareefa A. AlGhamdi, Salman Bakr Hosawi, Amira M. Alghamdi, Mustafa Zeyadi, Madan Mohan Gupta, Gaurav Gupta, Imran Kazmi
  • Patent number: 11590071
    Abstract: Provided are an injectable and implantable drug delivery composition and a method for using such composition to release active ingredients and/or pharmaceutical agents to a site of action. The composition includes a gellan-gum crosslinked with L-cysteine and at least one pharmaceutical active agent in a biocompatible solvent.
    Type: Grant
    Filed: July 6, 2021
    Date of Patent: February 28, 2023
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Imran Kazmi, Hemant Yadav, Fahad Fahad A. Al-Abbasi, Muhammad Shahid Nadeem, Hisham Altayeb, Muhammad Afzal, Gaurav Gupta, Abhay Raizaday
  • Publication number: 20230017509
    Abstract: Provided are an injectable and implantable drug delivery composition and a method for using such composition to release active ingredients and/or pharmaceutical agents to a site of action. The composition includes a gellan-gum crosslinked with L-cysteine and at least one pharmaceutical active agent in a biocompatible solvent.
    Type: Application
    Filed: July 6, 2021
    Publication date: January 19, 2023
    Inventors: Imran Kazmi, Hemant Yadav, Fahad Fahad A. Al-Abbasi, Muhammad Shahid Nadeem, Hisham Altayeb, Muhammad Afzal, Gaurav Gupta, Abhay Raizaday
  • Patent number: 11547690
    Abstract: Self-nanoemulsifying drug delivery system (SNEDDS) composition are provided. The compositions include at least one chemotherapeutic compound or a pharmaceutically acceptable salt thereof or mixture thereof, at least one biocompatible surfactant, wherein the at least one biocompatible surfactant includes surfactin, and at least one co-surfactant. Methods of enhancing the bioavailability of the chemotherapeutic compound and for treating cancer are also provided.
    Type: Grant
    Filed: June 28, 2022
    Date of Patent: January 10, 2023
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Imran Kazmi, Sarwar Beg, Mahroozur Rahman, Fahad A. Al-Abbasi, Muhammad Afzal, Hisham N. Altayeb
  • Patent number: 11311492
    Abstract: A nanomedicine for the treatment of obesity comprising either noble metal nanoparticles having surface ligands comprising a mixture comprising (+)-catechin (2R,3S) and gingerol or particles of a carbon nanomaterial having an adsorbed mixture comprising (+)-catechin (2R,3S) and gingerol. Also provided are a method for making the noble metal nanomedicine and the carbon nanomedicine. The nanomedicine is used in a method of treating obesity.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: April 26, 2022
    Assignee: King Abdulaziz University
    Inventors: Imran Kazmi, Syed Sarim Imam, Muhammad Afzal, Muhammad Shahid Nadeem, Fahad A. Al-Abbasi, Firoz Anwar
  • Patent number: 11234940
    Abstract: A nanomedicine for the treatment of obesity comprising either noble metal nanoparticles having surface ligands comprising a mixture comprising (+)-catechin (2R,3S) and gingerol or particles of a carbon nanomaterial having an adsorbed mixture comprising (+)-catechin (2R,3S) and gingerol. Also provided are a method for making the noble metal nanomedicine and the carbon nanomedicine. The nanomedicine is used in a method of treating obesity.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: February 1, 2022
    Assignee: King Abdulaziz University
    Inventors: Imran Kazmi, Syed Sarim Imam, Muhammad Afzal, Muhammad Shahid Nadeem, Fahad A. Al-Abbasi, Firoz Anwar
  • Patent number: 11219605
    Abstract: A nanomedicine for the treatment of obesity comprising either noble metal nanoparticles having surface ligands comprising a mixture comprising (+)-catechin (2R,3S) and gingerol or particles of a carbon nanomaterial having an adsorbed mixture comprising (+)-catechin (2R,3S) and gingerol. Also provided are a method for making the noble metal nanomedicine and the carbon nanomedicine. The nanomedicine is used in a method of treating obesity.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: January 11, 2022
    Assignee: King Abdulaziz University
    Inventors: Imran Kazmi, Syed Sarim Imam, Muhammad Afzal, Muhammad Shahid Nadeem, Fahad A. Al-Abbasi, Firoz Anwar
  • Patent number: 11129797
    Abstract: A nanomedicine for the treatment of obesity comprising either noble metal nanoparticles having surface ligands comprising a mixture comprising (+)-catechin (2R,3S) and gingerol or particles of a carbon nanomaterial having an adsorbed mixture comprising (+)-catechin (2R,3S) and gingerol. Also provided are a method for making the noble metal nanomedicine and the carbon nanomedicine. The nanomedicine is used in a method of treating obesity.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: September 28, 2021
    Assignee: King Abdulaziz University
    Inventors: Imran Kazmi, Syed Sarim Imam, Muhammad Afzal, Muhammad Shahid Nadeem, Fahad A. Al-Abbasi, Firoz Anwar