Patents by Inventor Imran Ozer

Imran Ozer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stimuli-responsive PEG-like polymer-based drug delivery platform
    Patent number: 12257308
    Abstract: Described herein are thermally responsive polymer-therapeutic molecule conjugates comprising a therapeutic molecule conjugated to a thermally responsive polymer with an acrylate, methacrylate, acrylamide, and/or methacrylamide backbone and a plurality of oligoethylene glycol side chains.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: March 25, 2025
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Imran Ozer
  • NON-IMMUNOGENIC POEGMA-APTAMER CONJUGATES
    Publication number: 20240226307
    Abstract: Disclosed are POEGMA-aptamer conjugates with a reduced or eliminated host-immune response. An example conjugate includes an aptamer conjugated to a POEGMA having a plurality of side chains, where each side chain includes 1 to 6 monomers of ethylene glycol repeated in tandem. Also disclosed are methods of making the conjugate and methods of using the conjugate. An example method of use includes a method of controlling coagulation in a subject.
    Type: Application
    Filed: February 22, 2022
    Publication date: July 11, 2024
    Inventors: Ashutosh Chilkoti, Bruce Sullenger, Imran Ozer, Angus Hucknall, Juliana Layzer, George Pitoc
  • POEGMA COPOLYMER CONJUGATES AND METHODS OF TREATING DISEASES
    Publication number: 20240181013
    Abstract: Disclosed are POEGMA copolymer conjugates that have phase transition behavior and a reduced or eliminated host-immune response. An example conjugate includes a biologically active agent and a copolymer of POEGMA conjugated to the biologically active agent where the conjugate has a transition temperature. The POEGMA copolymer conjugates can form drug releasing depots. which can be useful in methods of treating diseases.
    Type: Application
    Filed: April 1, 2022
    Publication date: June 6, 2024
    Inventors: Ashutosh Chilkoti, Imran Ozer
  • NON-IMMUNOGENIC POEGMA-APTAMER CONJUGATES
    Publication number: 20240131171
    Abstract: Disclosed are POEGMA-aptamer conjugates with a reduced or eliminated host-immune response. An example conjugate includes an aptamer conjugated to a POEGMA having a plurality of side chains, where each side chain includes 1 to 6 monomers of ethylene glycol repeated in tandem. Also disclosed are methods of making the conjugate and methods of using the conjugate. An example method of use includes a method of controlling coagulation in a subject.
    Type: Application
    Filed: February 22, 2022
    Publication date: April 25, 2024
    Inventors: Ashutosh Chilkoti, Bruce Sullenger, Imran Ozer, Angus Hucknall, Juliana Layzer, George Pitoc
  • STIMULI-RESPONSIVE PEG-LIKE POLYMER-BASED DRUG DELIVERY PLATFORM
    Publication number: 20210128734
    Abstract: Described herein are thermally responsive polymer-therapeutic molecule conjugates comprising a therapeutic molecule conjugated to a thermally responsive polymer with an acrylate, methacrylate, acrylamide, and/or methacrylamide backbone and a plurality of oligoethylene glycol side chains.
    Type: Application
    Filed: April 30, 2019
    Publication date: May 6, 2021
    Inventors: Ashutosh Chilkoti, Imran Ozer