Abstract: Provided herein are new devices for indicating the status of events, such as the number of relevant events that are remaining and/or that have already occurred up to the present moment and to related devices, systems, and methods. In some aspects, the event-related indicator devices of the invention are used within larger dispensing devices or systems, e.g., to provide the status of administration of a substance contained therein (e.g., a drug). In an exemplary embodiment, the indicator devices find particular utility within medicament dispensers, such as metered dose inhalers, to provide a visual indication of the status of doses having been or remaining to be administered.

Abstract: In some examples, data associated one or more medical presentations of a person is received. A mapping that associates the data to one or more candidate diagnoses is determined. The one or more candidate diagnoses correspond to one or more possible medical conditions associated with the person. A validation score for a first candidate diagnosis, of the one or more candidate diagnoses, is generated based on a set of features associated with the person. The validation score indicates an accuracy of the candidate diagnosis. At least partially in response to the generating of the validation score, an indicator is caused to be provided at a user device. The indicator indicates the validation score.

Abstract: Methods, systems, and computer-readable media are disclosed herein for automatically identifying and selecting, based on machine learning model(s), one or more patient educations instructions as suggested smart recommendations for a particular patient, based on parameter matching and filtering with other patient parameters. The parameters of a current patient can be automatically matched to parameters that are associated with other patients, on a one-to-one parameter basis or based on specific combinations parameters. Based on the presence of one or more shared parameters between a current patient and other patients as well as the strength of the parameter match, one or more instructions that were provided to the other patients can be recommended for the current patient automatically. Instruction(s) selected for the current patient can then be stored in association with the parameters of the current patient and used to evaluate and make recommendations for subsequent patients.

Abstract: In some examples, data associated one or more medical presentations of a person is received. A mapping that associates the data to one or more candidate diagnoses is determined. The one or more candidate diagnoses correspond to one or more possible medical conditions associated with the person. A validation score for a first candidate diagnosis, of the one or more candidate diagnoses, is generated based on a set of features associated with the person. The validation score indicates an accuracy of the candidate diagnosis. At least partially in response to the generating of the validation score, an indicator is caused to be provided at a user device. The indicator indicates the validation score.

Abstract: A breath actuated metered dose inhaler including a housing, a canister and a trigger mechanism. The trigger mechanism is activated by the inhalation of air which comprises of a diaphragm. The central rigid disk of the diaphragm is provided with the interlocking means to firmly secure and bound the peripheral flexible polymer ring with the central rigid disc. The mechanical interlock between a central rigid disk and a peripheral flexible polymer ring on the diaphragm prevent peripheral flexible polymer ring from being peeled off from the central rigid disc while the vacuum is being retained prior to inhalation.

Abstract: Provided herein are new devices for indicating the status of events, such as the number of relevant events that are remaining and/or that have already occurred up to the present moment and to related devices, systems, and methods. In some aspects, the event-related indicator devices of the invention are used within larger dispensing devices or systems, e.g., to provide the status of administration of a substance contained therein (e.g., a drug). In an exemplary embodiment, the indicator devices find particular utility within medicament dispensers, such as metered dose inhalers, to provide a visual indication of the status of doses having been or remaining to be administered.

Abstract: There is provided a dose counter assembly for use with a medicament dispenser, the dose counter assembly comprising: a) a units dose display means comprising a first count indicia and one or more driver teeth; b) a tens dose display means comprising a second count indicia; and c) a driver, wherein the first count indicia and second count indicia align at a common viewing area to collectively display a count sequence.

Abstract: Embodiments of the present disclosure describe methods, systems, and computer storage media for detecting sepsis in a maternal patient and causing for display a visual indicator of a graphical object. In some aspects sepsis may be detected based on a maternal patient's patient information and/or clinical diagnostic. Technologies described herein may be used to determine maternal-fetal sepsis and provide a graphical object of a patient's risk of the maternal-fetal sepsis. The visual indicator and graphical object may be identifiable to a clinician as a warning of a risk for maternal-fetal sepsis. In this way, maternal-fetal sepsis may be identified and a graphical object may be generated, facilitating timely treatment and early diagnosis of maternal-fetal sepsis.

Abstract: The invention of the present disclosure relates to a medicament dispenser for dispensing medicament from a plurality of elongate form medicament carriers, the dispenser comprising a dispensing mechanism for dispensing the medicament held within the dispenser, wherein the dispensing mechanism is capable of independently advancing each medicament carrier held within the dispenser, the dispensing mechanism comprising a driver, a carrier engagement for each medicament carrier for individually advancing the medicament dose portions thereof, an advancer for each carrier engagement, a flow director capable of dispensing a medicament dose from a plurality of medicament carriers, and a cover for the medicament access body operating as a component of the dispenser actuation mechanism.

Abstract: In some examples, data associated one or more medical presentations of a person is received. A mapping that associates the data to one or more candidate diagnoses is determined. The one or more candidate diagnoses correspond to one or more possible medical conditions associated with the person. A validation score for a first candidate diagnosis, of the one or more candidate diagnoses, is generated based on a set of features associated with the person. The validation score indicates an accuracy of the candidate diagnosis. At least partially in response to the generating of the validation score, an indicator is caused to be provided at a user device. The indicator indicates the validation score.

Abstract: Methods, systems, and computer-readable media are disclosed herein for automatically identifying and selecting, based on machine learning model(s), one or more patient educations instructions as suggested smart recommendations for a particular patient, based on parameter matching and filtering with other patient parameters. The parameters of a current patient can be automatically matched to parameters that are associated with other patients, on a one-to-one parameter basis or based on specific combinations parameters. Based on the presence of one or more shared parameters between a current patient and other patients as well as the strength of the parameter match, one or more instructions that were provided to the other patients can be recommended for the current patient automatically. Instruction(s) selected for the current patient can then be stored in association with the parameters of the current patient and used to evaluate and make recommendations for subsequent patients.

Abstract: The present disclosure relates to a medicament dispenser for dispensing medicament. The dispenser may be for use in dispensing medicament in a liquid, pressurized aerosol, pre-filled container and in any medicament dispenser where dose related feedback is required. Mechanisms and assemblies provide dose related feedback to the user of the medicament dispenser and the physical interfaces and attributes associated with providing such feedback. The present disclosure also relates to dose feedback assemblies that can be adapted to various form factors, various individual components and elements of the container-closure system, and/or various target user interfaces.

Abstract: Embodiments of the present disclosure describe methods, systems, and computer storage media for detecting sepsis in a maternal patient and causing for display a visual indicator of a graphical object. In some aspects sepsis may be detected based on a maternal patient's patient information and/or clinical diagnostic. Technologies described herein may be used to determine maternal-fetal sepsis and provide a graphical object of a patient's risk of the maternal-fetal sepsis. The visual indicator and graphical object may be identifiable to a clinician as a warning of a risk for maternal-fetal sepsis. In this way, maternal-fetal sepsis may be identified and a graphical object may be generated, facilitating timely treatment and early diagnosis of maternal-fetal sepsis.

Abstract: A medicament dispenser for dispensing medicament comprising: an assembly comprising: at least one peelable medicament carrier carrying multiple distinct medicament portions; a medicament carrier advancing mechanism; a flow channel; and a hinged cover for the flow channel.