Patents by Inventor Imre Mager

Imre Mager has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EXOSOMES COMPRISING THERAPEUTIC POLYPEPTIDES
    Publication number: 20230201370
    Abstract: The present invention pertains to an inventive release mechanism for extracellular vesicle (EV)-mediated intracellular and intramembrane delivery of therapeutic polypeptides. More specifically, the invention relates to EVs comprising polypeptide constructs which comprise a therapeutic polypeptide releasably attached to an exosomal polypeptide. Furthermore, the present invention pertains to manufacturing methods, pharmaceutical compositions, medical uses and applications, and various other embodiments related to the inventive EVs.
    Type: Application
    Filed: November 21, 2022
    Publication date: June 29, 2023
    Inventors: Justin HEAN, Imre MAGER, Matthew WOOD, Samir EL ANDALOUSSI, Oscar WIKLANDER, Joel NORDIN
  • Exosomes comprising therapeutic polypeptides
    Patent number: 11534499
    Abstract: The present invention pertains to an inventive release mechanism for extracellular vesicle (EV)-mediated intracellular and intramembrane delivery of therapeutic polypeptides. More specifically, the invention relates to EVs comprising polypeptide constructs which comprise a therapeutic polypeptide releasably attached to an exosomal polypeptide. Furthermore, the present invention pertains to manufacturing methods, pharmaceutical compositions, medical uses and applications, and various other embodiments related to the inventive EVs.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: December 27, 2022
    Assignees: Evox Therapeutics Ltd., Oxford University Innovation Limited
    Inventors: Justin Hean, Imre Mager, Matthew Wood, Samir El Andaloussi, Oscar Wiklander, Joel Nordin
  • EXOSOMES COMPRISING THERAPEUTIC POLYPEPTIDES
    Publication number: 20190167810
    Abstract: The present invention pertains to an inventive release mechanism for extracellular vesicle (EV)-mediated intracellular and intramembrane delivery of therapeutic polypeptides. More specifically, the invention relates to EVs comprising polypeptide constructs which comprise a therapeutic polypeptide releasably attached to an exosomal polypeptide. Furthermore, the present invention pertains to manufacturing methods, pharmaceutical compositions, medical uses and applications, and various other embodiments related to the inventive EVs.
    Type: Application
    Filed: May 25, 2017
    Publication date: June 6, 2019
    Applicants: Evox Therapeutics Ltd, Oxford University Innovation
    Inventors: Justin HEAN, Imre MAGER, Matthew WOOD, Samir EL ANDALOUSSI, Oscar WIKLANDER, Joel NORDIN
  • CHEMICALLY MODIFIED CELL-PENETRATING PEPTIDES FOR IMPROVED DELIVERY OF GENE MODULATING COMPOUNDS
    Publication number: 20140140929
    Abstract: The present invention relates to a system for intracellular delivery of a cargo comprising at least one component A chosen from aliphatic linear or branched moieties with at least 4 carbon atoms and/or cyclic ring systems comprising 2-4 rings which may contain several hetero atoms chosen from N, S, O and P, wherein component(s) A is (are) attached to a cell penetrating peptide B and/or a non-peptide analogue thereof. It also relates to methods of using the system in diagnosis of diseases, as research tool and as a targeting system, a composition comprising the system and especially a pharmaceutical composition a material covered with the system and a material having the delivery systems into the material. Finally it relates to novel peptides.
    Type: Application
    Filed: November 6, 2013
    Publication date: May 22, 2014
    Inventors: KARIEM AHMED, SAMIR EL ANDALOUSSI, PETER GUTERSTAM, MATTIAS HALLBRINK, HENRIK JOHANSSON, ULO LANGEL, TAAVI LEHTO, MARIA LINDGREN, IMRE MAGER, RANNAR SILLARD, KATRI ROSENTHAL AIZMAN, ULF TEDEBARK, PER LUNDIN
  • CHEMICALLY MODIFIED CELL-PENETRATING PEPTIDES FOR IMPROVED DELIVERY OF GENE MODULATING COMPOUNDS
    Publication number: 20110212028
    Abstract: The present invention relates to a system for intracellular delivery of a cargo comprising at least one component A chosen from aliphatic linear or branched moieties with at least 4 carbon atoms and/or cyclic ring systems comprising 2-4 rings which may contain several hetero atoms chosen from N, S, O and P, wherein component(s) A is (are) attached to a cell penetrating peptide B and/or a non-peptide analogue thereof. It also relates to methods of using the system in diagnosis of diseases, as research tool and as a targeting system, a composition comprising the system and especially a pharmaceutical composition a material covered with the system and a material having the delivery systems into the material. Finally it relates to novel peptides.
    Type: Application
    Filed: September 16, 2009
    Publication date: September 1, 2011
    Inventors: Kariem Ahmed, Samir El Andaloussi, Peter Gutrestam, Mattias Hallbrink, Henrik Johansson, Ulo Langel, Taavi Lehto, Maria Lindgren, Imre Mager, Rannar Sillard, Katri Rosenthal Aizman, Ulf Tedebark, Per Lundin