Patents by Inventor Imre Mezo

Imre Mezo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for reversing drug resistance
    Patent number: 6297216
    Abstract: The invention features novel peptide derivatives called Reversins, and provides for their use in a method of reducing the activity of the multi-drug transporter protein MDR1 in order to overcome multidrug resistance in a mammal. The peptide derivatives are of the formula (I) X1n-X2-X3(X4)n-X5, wherein n is 0 or 1, and each n is the same or different; X1 is BOC, BOC-Asu, Z-Asu, benzyloxycarbonyl, Glu(OBzl)-OBzl, Trp-OMe, Trp-Phe-OMe, Phe-Trp-OMe, Phe-Phe-OtBu, Trp-Trp-OtBu, indoloacetyl, benzoyl, an alkylanine of 1-4 carbons, dibenzylamide, tryptamide, 1-amino-adamantine, aminomethylcyclohexane, indoline, phenylethylamide or dicyclohexylamide; X2 is Glu(OBzl), Asp(OBzl), succinyl, O,O-dibenzoyltartaroyl, diphenoyl, muconyl, Thx, Cpa, Asu, Nal, Pen, Phg, Dbt, Lys(BOC), Lys(Z), Cys(Bzl), Thr(Bzl), Glu(OtBu), tert.-Leu, Leu, Nle, Pro, Phe, Tyr(Bzl), or Ser(Bal); X3 is Asp, Asu, Lys, Glu, Trp, Thx, Cpa, Nal, Pen, Phg, Dbt, Glu(OtBu), tert.
    Type: Grant
    Filed: February 19, 1997
    Date of Patent: October 2, 2001
    Assignee: Solvo Biotechnology
    Inventors: Balazs Sarkadi, Janos Seprodi, Orsolya Csuka, Maria Magocsi, Imre Mezo, Istvan Palyi, Istvan Teplan, Zsolt Vadasz, Borbala Vincze
  • Anti-tumor effects of GnRH-III
    Patent number: 5593965
    Abstract: The present invention provides a novel pharmaceutical composition for the treatment of breast cancer. Also provided are various methods of treating breast cancer.
    Type: Grant
    Filed: October 20, 1994
    Date of Patent: January 14, 1997
    Assignee: Creighton University
    Inventors: Sandor Lovas, J. Michael Conlon, Borbala Vincze, Istvan Palyi, Dezso Gaal, Adrienn Kalnay, Imre Mezo, Istvan Teplan, Geza Toth, Magdolna Kovacs
  • Tumor growth-inhibiting somatostatin analogues, pharmaceutical compositions containing them and process for preparing same
    Patent number: 5480870
    Abstract: The invention relates to tumor-inhibiting heptapeptide and octapeptide amide derivatives and to a method of treating mammals, including men, suffering from tumors or from the excessive secretion of insulin, glucagon or growth hormone using these compounds.
    Type: Grant
    Filed: April 26, 1994
    Date of Patent: January 2, 1996
    Assignee: Biosignal Kutato-Fejlesztokft
    Inventors: Gyorgy Keri, Imre Mezo, Aniko Horvath, Zsolt Vadasz, Istvan Teplan, Agnes Balogh, Orsolya Csuka, Gyongyi Bokonyi, Balas Szoke, Judit Horvath, Miklos Idei, Janos Seprodi
  • Analogs of growth hormone releasing factor (GRF) and a method for the preparation thereof
    Patent number: 5023322
    Abstract: The invention relates to new peptides of the formula ##STR1## wherein R.sup.2 represents Ala or D-Ala,R.sup.11 represents Arg or D-Arg,R.sup.13 represents Val or Ile,R.sup.15 represents Gly, Leu, Phe or a valence bond,R.sup.27 represents Met or Nle,R.sup.28 represents Ser, D-Ser or Asn, andY represents OH or NH.sub.2,and to salts thereof. These compounds stimulate the release of growth hormone and can be used in the therapy as well as for veterinary or animal husbandry purposes.
    Type: Grant
    Filed: August 30, 1989
    Date of Patent: June 11, 1991
    Assignee: MTA Kutatas-es Szervezetelemzo Intezete
    Inventors: Magdolna Kovacs, Judit Horvath, Sandor Vigh, Imre Mezo, Istvan Teplan, Balazs Szoke, Janos Seprodi, Zsolt Vadasz, Edit Hegedus, Gabor Makara, Gyorgy Rappay
  • Gonadoliberin derivatives containing a .beta.-aspartyl group, a process for the preparation thereof and pharmaceutical preparations containing them
    Patent number: 4600705
    Abstract: The invention relates to novel gonadoliberine derivatives of the general formula (I) ##STR1## wherein X represents an --O--R group wherein R is a benzyl group or a C.sub.1-4 alkyl group, an ##STR2## group wherein R1 and R2 independently stand for hydrogen, a C.sub.1-5 alkyl, aryl, aryl-C.sub.1-2 -alkyl, morpholino, 1-indolinyl or 1-pyrrolidinyl group,Y is a glycine amide or a C.sub.1-4 -alkyl-amide group,the addition salts thereof formed with acids used in therapy and complexes thereof as well as pharmaceutical compositions containing them, furthermore to a process for the preparation of the above compounds.The reproductive processes of vertebrates can be advantageously influenced with the compounds of general formula (I).
    Type: Grant
    Filed: March 29, 1984
    Date of Patent: July 15, 1986
    Assignee: Richter Gedeon Veyteszeti Gyar R.T.
    Inventors: Janos Seprodi, Istvan Teplan, Imre Mezo, Judit rchegyi
  • Gonadoliberin derivatives process for the preparation and pharmaceutical compositions thereof
    Patent number: 4552864
    Abstract: The invention relates to new gonadoliberin derivatives of the formula (I)Glp-His-Trp-Ser-Tyr-X-Leu-Arg-Pro-Y, (I)whereinY represents a glycine-amide group or an -NH-alkyl group having 1 to 4 carbon atoms in the alkyl moiety,X stands for a D-thyroxyl, D-thyronyl or D-4-chlorophenylalanyl group,and acid addition salts and metal complexes thereof.The new nona- and decapeptide derivatives have an excellent luteinizing and folliculus stimulating hormone releasing activity, and they can therefore be used as active ingredients in pharmaceutical compositions for human or veterinary application.
    Type: Grant
    Filed: May 4, 1984
    Date of Patent: November 12, 1985
    Assignee: Reanal Finomvegyszergyar
    Inventors: Ferenc Antoni, Judit Erchegyi, Aniko Horvath, Gyorgi Keri, Imre Mezo, Karoly Nikolics, Janos Seprodi, Andras Szell, Balazs Szoke, Istvan Teplan