Patents by Inventor Imre ROZSUMBERSZKI
Imre ROZSUMBERSZKI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11958798Abstract: The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formula I and 16(S)-iloprost of formula (S)-I in solid, crystalline form.Type: GrantFiled: October 25, 2022Date of Patent: April 16, 2024Assignee: EUROAPI HUNGARY LIMITED LIABILITY COMPANYInventors: Imre Rozsumberszki, Zsuzsanna Kardos, Irén Hortobágyi, Tibor Szabó, Csaba Váradi, Tamás Bán
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Patent number: 11724979Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.Type: GrantFiled: July 15, 2021Date of Patent: August 15, 2023Assignee: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre Juhász, Irén Hortobágyi, Tamás Altsach, István Lászlófi, Ágnes Nagyné Borkó, Imre Rozsumberszki, Gábor Havasi, Zsuzsanna Kardos, Péter Buzder-Lantos
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Publication number: 20230115500Abstract: The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formula I and 16(S)-iloprost of formula (S)-I in solid, crystalline form.Type: ApplicationFiled: October 25, 2022Publication date: April 13, 2023Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre ROZSUMBERSZKI, Zsuzsanna KARDOS, Irén HORTOBÁGYI, Tibor SZABÓ, Csaba VÁRADI, Tamás BÁN
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Patent number: 11535580Abstract: The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formula I and 16(S)-iloprost of formula (S)-I in solid, crystalline form.Type: GrantFiled: April 16, 2019Date of Patent: December 27, 2022Assignee: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre Rozsumberszki, Zsuzsanna Kardos, Irén Hortobágyi, Tibor Szabó, Csaba Váradi, Tamás Bán
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Publication number: 20210340093Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.Type: ApplicationFiled: July 15, 2021Publication date: November 4, 2021Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre JUHÁSZ, Irén HORTOBÁGYI, Tamás ALTSACH, István LÁSZLÓFI, Ágnes NAGYNÉ BORKÓ, Imre ROZSUMBERSZKI, Gábor HAVASI, Zsuzsanna KARDOS, Péter BUZDER-LANTOS
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Patent number: 11098001Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.Type: GrantFiled: April 29, 2019Date of Patent: August 24, 2021Assignee: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre Juhász, Irén Hortobágyi, Tamás Altsach, István Lászlófi, Ágnes Nagyné Borkó, Imre Rozsumberszki, Gábor Havasi, Zsuzsanna Kardos, Péter Buzder-Lantos
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Publication number: 20210147329Abstract: The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formula I and 16(S)-iloprost of formula (S)-I in solid, crystalline form.Type: ApplicationFiled: April 16, 2019Publication date: May 20, 2021Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre ROZSUMBERSZKI, Zsuzsanna KARDOS, Irén HORTOBÁGYI, Tibor SZABÓ, Csaba VÁRADI, Tamás BÁN
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Publication number: 20190248725Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.Type: ApplicationFiled: April 29, 2019Publication date: August 15, 2019Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre JUHÁSZ, Irén HORTOBÁGYI, Tamás ALTSACH, István LÁSZLÓFI, Ágnes NAGYNÉ BORKÓ, Imre ROZSUMBERSZKI, Gábor HAVASI, Zsuzsanna KARDOS, Péter BUZDER-LANTOS
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Patent number: 10322990Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.Type: GrantFiled: September 28, 2015Date of Patent: June 18, 2019Assignee: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre Juhász, Irén Hortobágyi, Tamás Altsach, István Lászlófi, Ágnes Nagyné Borkó, Imre Rozsumberszki, Gábor Havasi, Zsuzsanna Kardos, Péter Buzder-Lantos
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Publication number: 20170313643Abstract: The invention provides a new process for the preparation of treprostinil of formula (I) and its salts using several new intermediates during the building of the ring system.Type: ApplicationFiled: September 28, 2015Publication date: November 2, 2017Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre JUHÁSZ, Irén HORTOBÁGYI, Tamás ALTSACH, István LÁSZLÓFI, Ágnes NAGYNÉ BORKÓ, Imre ROZSUMBERSZKI, Gábor HAVASI, Zsuzsanna KARDOS, Péter BUZDER-LANTOS